Search results for "maintenance"

Pharmacodynamic Monitoring of the Efficacy of a Targeted Therapy with Midostaurin By Plasma Inhibitor Activity (PIA) Analysis in FLT3 -ITD Positive A…

2015

Abstract Background: Activating mutations in receptor tyrosine kinases like FLT3 (FLT3mut) lead to an aberrant signal transduction thereby causing an increased proliferation of hematopoietic cells. Internal tandem duplications (FLT3-ITD) or mutations in the tyrosine kinase domain (FLT3-TKD) occur in about 25% of younger adult patients (pts) with acute myeloid leukemia (AML), with FLT3 -ITD being associated with an unfavourable outcome. FLT3mut present an excellent target for small molecule tyrosine kinase inhibitors (TKI). The multi-targeted kinase inhibitor midostaurin (PKC412) is currently under investigation as a FLT3-inhibitor in combination with intensive chemotherapy. Monitoring of th…

REVIEW OF GUIDELINES FOR PV SYSTEMS PERFORMANCE AND DEGRADATIONS MONITORING

2018

35th European Photovoltaic Solar Energy Conference and Exhibition; 2037-2050

Predictors of tooth loss due to periodontal disease in patients following long‐term periodontal maintenance

2015

The pioneering attempt to characterize the response to periodontal treatment of patients undergoing periodontal maintenance (PM) (Wasserman & Hirschfeld 1988) was soon followed by the first studies on periodontal prognosis (McGuire 1991, McGuire & Nunn 1996a,b, McLeod et al. 1998). Two main conclusions were drawn, which remain generally accepted: establishing a periodontal prognosis is the basis of any treatment plan, and actual knowledge of the predictors of tooth loss (TL) is very limited. An extensive review on the subject noted the heterogeneity of the studies and the scarce information that could be drawn from them (Chambrone et al. 2010). Several statistical models analysing the predi…

La vida cotidiana de los vecinos de Manila a través de sus testamentos e inventarios de bienes

2019

With the general objective indicated in its title, this work tries to highlight relevant aspects in the continuity of the Spanish domain in the Philippines, dependent on the maintenance of the Spanish capital. The inevitable selection of topics has lead the preferences of this work towards the residents collaboration to defend the city, the conversion of many of them into traders of exotic products and singular slaves owners, and their collaboration to an incredible miscegenation due to the ethnic variety. On the other hand, to follow the footsteps of the first generation of residents in Manila, at the end of the 16th century and during the 17th century, this work gives us some information …

Accentuating the Positive, Eliminating the Negative? Relationship Maintenance as a Predictor of Two-Dimensional Relationship Quality

2012

In this study, relationship maintenance and its connections with positive and negative relationship quality were examined among Finnish parents (N = 177 women and 153 men; i.e., partners from 150 couples and 27 women and 3 men whose partner did not participate in the study). Relationship maintenance was measured using Stafford, Dainton, and Haas's (2000) version of the RMSM and two-dimensional relationship quality using Fincham and Linfield's (1997) PANQIMS. Structural equation modeling was utilized to analyze paired data. Women were found to report more relationship maintenance behaviors than their partners. The results showed further that relationship maintenance was connected with both p…

Impact of Age and Midostaurin-Dose on Response and Outcome in Acute Myeloid Leukemia with FLT3-ITD: Interim-Analyses of the AMLSG 16-10 Trial

2016

Abstract Background: Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in roughly 25% of younger adult patients (pts) with acute myeloid leukemia (AML). The multi-targeted kinase inhibitor midostaurin combined with intensive chemotherapy has shown activity against AML with FLT3 mutations. However, toxicity and potential drug-drug interactions with strong CYP3A4 inhibitors such as posaconazole may necessitate dose reduction. Aims: To evaluate the impact of age and midostaurin dose-adaptation after intensive induction chemotherapy on response and outcome in AML with FLT3-ITD within the AMLSG 16-10 trial (NCT01477606). Methods: The study included adult pts (age 18-7…

A cost model for the selection of a maintenance activity in a series system

2012

DECISION-MAKING MODELS FOR PREDICTIVE MAINTENANCE SERVICE SUPPORT SYSTEMS

2023

Nell'era digitale, la tecnologia è in continua evoluzione, con enormi progressi nell'automazione che consentono una gestione della manutenzione più efficiente ed economica. Le tecnologie digitali stanno convergendo e avanzando insieme alle industrie, determinando progressi significativi nella gestione della manutenzione. La tradizionale strategia di manutenzione preventiva gestita dall'uomo lascia progressivamente spazio alla manutenzione predittiva, che rappresenta un’ottima opportunità per migliorare significativamente la pianificazione della manutenzione del sistema, in particolare per i sistemi più complessi e dal significativo valore monetario. Tuttavia, l’implementazione di tecniche d…

Overcoming managers’ myopic decisions in a waste collection company

2019

Purpose The purpose of this paper is to show how the changing interrelationships between fleet management, human resources and outsourcer capacity areas are likely to counterbalance managerial policies, thereby generating a performance decay. The use of system dynamics modelling in a waste collection company offered an effective contribution to support decision makers to overcoming myopic decisions. Design/methodology/approach Literature review and a case study analysis (including interviews with company actors and data gathering) offered the basis to build a system dynamics model. The model built was then used to run simulations sessions to assess alternative investments decisions. Findin…

The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever u…

2012

Abstract Background Divergent strategies have emerged for the management of severe asthma. One strategy utilises high and fixed doses of maintenance treatment, usually inhaled corticosteroid/long-acting β2-agonist (ICS/LABA), supplemented by a short-acting β2-agonist (SABA) as needed. Alternatively, budesonide/formoterol is used as both maintenance and reliever therapy. The latter is superior to fixed-dose treatment in reducing severe exacerbations while achieving similar or better asthma control in other regards. Exacerbations may be reduced by the use of budesonide/formoterol as reliever medication during periods of unstable asthma. We examined the risk of a severe exacerbation in the per…