Search results for "maintenance"
showing 10 items of 392 documents
Multi-State System in human reliability analysis
2009
Application of mathematical model of Multi-State System for human reliability analysis is considered in the paper. This paper describes new method for estimation of changes of more than one component states and they influence to Multi-State System reliability by Dynamic Reliability Indices. The Multi-State System failure is considered depending on decrease of some system component efficiency and the Multi-State System repair is declared depending on replacement of some failed components. The mathematical approach of Logical Differential Calculus is used for analysis of the Multi-State System reliability change that is caused by modifications of some system components states.
Integrated Production and Predictive Maintenance Planning based on Prognostic Information
2019
International audience; This paper address the problem of scheduling production and maintenance operation in predictive maintenance context. It proposes a contribution in the decision making phase of the prognostic and health management framework. Theprognostics and decision processes are merged and an ant colony optimization approach for finding the sequence of decisions that optimizes the benefits of a production system is developed. A case study on a single machine composed of several components where machine can have several usage profiles. The results show thatour approach surpasses classical condition based maintenance policy.
IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: A randomised, double‐blind, multi‐center cross‐over non‐inferiority s…
2018
Intravenous immunoglobulin (IVIg) is the gold-standard for maintenance treatment of multifocal motor neuropathy (MMN). This phase III, randomised, double-blind, multi-centre, active-control, crossover study, aimed to evaluate the non-inferiority of IqYmune® relative to Kiovig®, primarily based on efficacy criteria. Twenty-two adult MMN patients, treated with any brand of IVIg (except Kiovig® or IqYmune®) at a stable maintenance dose within the range of 1 to 2 g/kg every 4 to 8 weeks, were randomised to receive either Kiovig® followed by IqYmune®, or IqYmune® followed by Kiovig®. Each product was administered for 24 weeks. The primary endpoint was the difference between IqYmune® and Kiovig® …
Comparing motivational, self-regulatory and habitual processes in a computer-tailored physical activity intervention in hospital employees - protocol…
2017
Abstract Background Most people do not engage in sufficient physical activity to confer health benefits and to reduce risk of chronic disease. Healthcare professionals frequently provide guidance on physical activity, but often do not meet guideline levels of physical activity themselves. The main objective of this study is to develop and test the efficacy of a tailored intervention to increase healthcare professionals’ physical activity participation and quality of life, and to reduce work-related stress and absenteeism. This is the first study to compare the additive effects of three forms of a tailored intervention using different techniques from behavioural theory, which differ accordin…
Phase III study of regorafenib versus placebo as maintenance therapy in RAS wild type metastatic colorectal cancer (RAVELLO trial)
2015
TPS789 Background: Treatment of metastatic colorectal cancer (mCRC) has improved due to the introduction of more active chemotherapies (CT) and novel targeted agents that have significantly increased response rate (RR), progression free survival (PFS) and overall survival (OS). Recently, CORRECT and CONCUR trials have demonstrated both activity and efficacy of regorafenib, a small multi-kinase inhibitor, as monotherapy in pretreated mCRC. The wide range of action of regorafenib makes it an ideal candidate for monotherapy in earlier disease treatment lines in which different pathways could be involved in the acquisition of resistance. To improve long term efficacy of first line therapy seve…
Dalla villa del principe di Cattolica al museo Guttuso di Bagheria (Italia): fra compatibilità, minimo intervento e massima conservazione
2014
Il complesso monumentale di villa Cattolica di Bagheria (Italia), è ubicato a pochi chilometri da Palermo, è rappresenta un notevole esempio di residenza suburbana costruita nel XVII e completata solo nella prima metà del XVIII secolo. La villa, oggi, nella sua composizione planimetrica, è caratterizzata da un elemento architettonico centrale, segnato da due esedre, impostato su un lieve aumento, circondato da edifici bassi, formanti un recinto quadrangolare lobato, contenente, tra l’altro, la chiesa di corte, le abitazioni dei famigli e le scuderie. Villa Cattolica, alla fine del XVIII secolo, dopo la cessione da parte della famiglia Bonanno, è stata utilizzata come ospedale e caserma, inf…
Theoretical construct, method and working tool of the “Preventive Restoration”
2014
A restoration may constitute a positive moment to guarantee the conservation, transmission and a compatible use of an historical architecture, but it is often the result of a long and guilty omission of care, attesting a lack of interest in the architectural heritage we are late forced to heal with extensive and inva-sive interventions that, in most cases, could be prevented. Clear maintenance programs and a correct and well-planned preventive action could be sufficient to avoid unexpected interventions when it is too late; such simple concepts - apparently shared by everyone - however, remain rele-gated to a level of brainy attitudes or protocols that do not produce any ad-vantage in terms…
Restauro, attività di ricerca e conservazione
2012
Il capitolo tratta i metodi di restauro di una superficie architettonica di "finta pietra". In particolare, l'attenzione è rivolta ai metodi di pulitura, consolidamento e reintegrazione dei rivestimenti d'intonaco; la trattazione si avvale di immagini che sono tratte dai cantieri di restauro. This chapter explains the methods of restoration of an architectural surface. In particular, attention is directed to methods of cleaning, consolidation and reintegration of plaster coatings and the treatise makes use of images of restoration sites.
p27Kip1participates in the regulation of endoreplication in differentiating chick retinal ganglion cells
2015
Nuclear DNA duplication in the absence of cell division (i.e. endoreplication) leads to somatic polyploidy in eukaryotic cells. In contrast to some invertebrate neurons, whose nuclei may contain up to 200,000-fold the normal haploid DNA amount (C), polyploid neurons in higher vertebrates show only 4C DNA content. To explore the mechanism that prevents extra rounds of DNA synthesis in these latter cells we focused on the chick retina, where a population of tetraploid retinal ganglion cells (RGCs) has been described. We show that differentiating chick RGCs that express the neurotrophic receptors p75 and TrkB while lacking retinoblastoma protein, a feature of tetraploid RGCs, also express p27K…
Hypertext support for the information needs of software maintainers
2004
Making changes safely to programs requires program comprehension and satisfaction of the information needs of software maintainers. In this paper we provide insights into improving hypertext-based software maintenance support by analyzing those information needs. There exists a series of four earlier, detailed-level empirical studies on the information needs of professional C program maintainers. We focus on these studies, synthesize their results and determine sources from which the required information might be attained. An experimental research tool, the HyperSoft system, is used to demonstrate the satisfaction of information needs and the system is analytically evaluated against the nee…