Search results for "mapping"
showing 10 items of 1508 documents
MALDI MS imaging as a powerful tool for investigating synovial tissue
2012
To identify and image protein biomarker candidates in the synovial tissue of patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA).A novel matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) technique was applied to the analysis of synovial tissue. Patients were classified according to the American College of Rheumatology (ACR) criteria for RA. Frozen sections were stained to obtain morphological data. Serial sections were desiccated, and spotted with matrix for MALDI analysis. Ions generated by laser irradiation of the tissue were separated in time, based on their m/z ratio, and were subsequently detected. IMS was used in a 'profiling…
New protein clustering of breast cancer tissue proteomics using actin content as a cellularity indicator
2008
In the present study, we report the comparative proteome profiles of proteins solubilized from 37 breast cancer surgical tissues, normalized for the actin content. Blood-derived proteins were excluded from the analysis. Among the tumor-derived protein spots, a large proportion (39%) was found present in all patients. These included several glycolytic enzymes, detox and heat shock proteins, members of annexin and S100 protein families, cathepsin D, and two “rare” proteins, DDAH2 involved in the angiogenesis control, and the oncogene PARK7. Other proteins, such as psoriasin, galectin1, cofilin, peroredoxins, SH3L1, and others, showed sporadic presence and high expression level, which suggests…
Serum and antibodies of glaucoma patients lead to changes in the proteome, especially cell regulatory proteins, in retinal cells.
2012
PURPOSE: Previous studies show significantly specifically changed autoantibody reactions against retinal antigens in the serum of glaucoma and ocular hypertension (OHT) patients in comparison to healthy people. As pathogenesis of glaucoma still is unknown the aim of this study was to analyze if the serum and antibodies of glaucoma patients interact with neuroretinal cells. METHODS: R28 cells were incubated with serum of patients suffering from primary open angle glaucoma (POAG), normal tension glaucoma (NTG) or OHT, POAG serum after antibody removal and serum from healthy people for 48 h under a normal or an elevated pressure of 15000 Pa (112 mmHg). RGC5 cells were additionally incubated wi…
Graphical metric space: a generalized setting in fixed point theory
2016
Building on recent ideas of Jachymski, we work on the notion of graphical metric space and prove an analogous result for the contraction mapping principle. In particular, the triangular inequality is replaced by a weaker one, which is satisfied by only those points which are situated on some path included in the graphical structure associated with the space. Some consequences, examples and an application to integral equations are presented to confirm the significance and unifying power of obtained generalizations.
Characterizing the Theory of Mind Network in Schizophrenia Reveals a Sparser Network Structure
2021
AbstractImpaired social functioning is a hallmark of schizophrenia and altered functional integration between distant brain regions are expected to account for signs and symptoms of the disorder. The functional neuroarchitecture of a network relevant for social functioning, the mentalizing network, is however poorly understood. In this study we examined dysfunctions of the mentalizing network in patients with schizophrenia compared to healthy controls via dynamic causal modelling and an interactive social decision-making game. Network characteristics were analyzed on a single subject basis whereas graph theoretic metrics such as in-degree, out-degree and edge-connectivity per network node w…
Perceptions of Cultural Ecosystem Services: spatial differences in urban and rural areas of Kokemäenjoki, Finland
2021
This study aims to identify and evaluate the spatial distribution of Cultural Ecosystem Services (CES) benefits perceived by people in both urban and rural areas. A public participation GIS (PPGIS)...
Anomalous partially hyperbolic diffeomorphisms III: Abundance and incoherence
2020
Let $M$ be a closed 3-manifold which admits an Anosov flow. In this paper we develop a technique for constructing partially hyperbolic representatives in many mapping classes of $M$. We apply this technique both in the setting of geodesic flows on closed hyperbolic surfaces and for Anosov flows which admit transverse tori. We emphasize the similarity of both constructions through the concept of $h$-transversality, a tool which allows us to compose different mapping classes while retaining partial hyperbolicity. In the case of the geodesic flow of a closed hyperbolic surface $S$ we build stably ergodic, partially hyperbolic diffeomorphisms whose mapping classes form a subgroup of the mapping…
Small $C^1$ actions of semidirect products on compact manifolds
2020
Let $T$ be a compact fibered $3$--manifold, presented as a mapping torus of a compact, orientable surface $S$ with monodromy $\psi$, and let $M$ be a compact Riemannian manifold. Our main result is that if the induced action $\psi^*$ on $H^1(S,\mathbb{R})$ has no eigenvalues on the unit circle, then there exists a neighborhood $\mathcal U$ of the trivial action in the space of $C^1$ actions of $\pi_1(T)$ on $M$ such that any action in $\mathcal{U}$ is abelian. We will prove that the same result holds in the generality of an infinite cyclic extension of an arbitrary finitely generated group $H$, provided that the conjugation action of the cyclic group on $H^1(H,\mathbb{R})\neq 0$ has no eige…
Coupled coincidence points for compatible mappings satisfying mixed monotone property
2012
We establish coupled coincidence and coupled fixed point results for a pair of mappings satisfying a compatibility hypothesis in partially ordered metric spaces. An example is given to illustrate our obtained results.
Cyclic admissible contraction and applications to functional equations in dynamic programming
2015
In this paper, we introduce the notion of T-cyclic $( \alpha ,\beta ) $ -contraction and give some common fixed point results for this type of contractions. The presented theorems extend, generalize, and improve many existing results in the literature. Several examples and applications to functional equations arising in dynamic programming are also given in order to illustrate the effectiveness of the obtained results.