Search results for "maps"
showing 10 items of 236 documents
The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model
2017
Glaucoma is a neurodegenerative disease that leads to irreversible retinal ganglion cell (RGC) loss and is one of the main causes of blindness worldwide. The pathogenesis of glaucoma remains unclear, and novel approaches for neuroprotective treatments are urgently needed. Previous studies have revealed significant down-regulation of α-crystallin B as an initial reaction to elevated intraocular pressure (IOP), followed by a clear but delayed up-regulation, suggesting that this small heat-shock protein plays a pathophysiological role in the disease. This study analyzed the neuroprotective effect of α-crystallin B in an experimental animal model of glaucoma. Significant IOP elevation induced b…
The latent geometry of the human protein interaction network
2017
Abstract Motivation A series of recently introduced algorithms and models advocates for the existence of a hyperbolic geometry underlying the network representation of complex systems. Since the human protein interaction network (hPIN) has a complex architecture, we hypothesized that uncovering its latent geometry could ease challenging problems in systems biology, translating them into measuring distances between proteins. Results We embedded the hPIN to hyperbolic space and found that the inferred coordinates of nodes capture biologically relevant features, like protein age, function and cellular localization. This means that the representation of the hPIN in the two-dimensional hyperboli…
Exploring the Human-Nipah Virus Protein-Protein Interactome
2017
ABSTRACT Nipah virus is an emerging, highly pathogenic, zoonotic virus of the Paramyxoviridae family. Human transmission occurs by close contact with infected animals, the consumption of contaminated food, or, occasionally, via other infected individuals. Currently, we lack therapeutic or prophylactic treatments for Nipah virus. To develop these agents we must now improve our understanding of the host-virus interactions that underpin a productive infection. This aim led us to perform the present work, in which we identified 101 human-Nipah virus protein-protein interactions (PPIs), most of which (88) are novel. This data set provides a comprehensive view of the host complexes that are manip…
Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1
2020
Background: Several experimental models of polyglutamine (polyQ) diseases have been previously developed that are useful for studying disease progression in the primarily affected central nervous system. However, there is a missing link between cellular and animal models that would indicate the molecular defects occurring in neurons and are responsible for the disease phenotype in vivo. Methods: Here, we used a computational approach to identify dysregulated pathways shared by an in vitro and an in vivo model of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ disease spinocerebellar ataxia type-1 (SCA1). Results: A set of common dysregulated pathwa…
Multivariate statistical analysis of a large odorants database aimed at revealing similarities and links between odorants and odors
2017
International audience; The perception of odor is an important component of smell; the first step of odor detection, and the discrimination of structurally diverse odorants depends on their interactions with olfactory receptors (ORs). Indeed, the perception of an odor's quality results from a combinatorial coding, in which the deciphering remains a major challenge. Several studies have successfully established links between odors and odorants by categorizing and classifying data. Hence, the categorization of odors appears to be a promising way to manage odors. In the proposed study, we performed a computational analysis using odor descriptions of the odorants present in Flavor-Base 9th Edit…
The social networks of young people with intellectual disabilities during the On-Campus supported adult education programme
2016
<p>This article describes the social networks of four young people with intellectual disabilities in supported adult education, focusing on their inclusion in school and leisure environments. A multiple case study approach with content analysis was used. Data were collected through interviews with young people and their family members, relationship maps, observation journals and notes from Personal Futures Planning meetings. Relationships with family members, other relatives and neighbours were close. One participant had a friend of her own age with no disabilities. The other three had varying, superficial peer relationships and friends of the family. All the participants had heteroge…
Una segregazione paradossale e multi-scalare: il caso del quartiere ZEN di Palermo
2016
L’articolo affronta la questione della segregazione nel quartiere ZEN di Palermo (Sicilia). L’impianto teorico dialoga con la letteratura anglosassone, ma ne prende le distanze nel tentativo di individuare alcune specificità locali del caso. L’obiettivo è duplice: intanto indentificare alcuni “movimenti geostorici” che hanno caratterizzato il quartiere, collegando a ciascuno di questi una fase del processo segregativo; inoltre, rappresentare la segregazione del quartiere in forma cartografica, mediante l’uso di alcuni ideogrammi e mappe mentali. This article deals with the issue of segregation in the ZEN district of Palermo, Sicily. The theoretical framework is built around Anglo-Saxon refe…
Āru vārdi 17. gadsimta beigu Vidzemes kartēs. Sāvienas (Sawensee) un Aburtu (Lüggen) muižas piemērs
2020
Vidzeme, one of the cultural and historical regions of Latvia, became a part of the kingdom of Sweden during the 17th century. Subsequently, Swedish cartographers mapped the estates of Vidzeme and then compiled maps of larger territories then called castle districts. The present research inspects 11 of these late 17th century maps and analyzes the microtoponyms found there. For an illustration, the maps of Sāviena (Sawensee) and Aburti (Lüggen) estates are chosen. This paper consider as microtoponyms not only the names of meadows, forests, swamps and hills, but also some hydronyms denoting smaller rivers and lakes that had not yet been academically analyzed, in total names of 26 objects. Th…
The geometers of the cadastre of Catalonia (1720-1815)
2009
El Cadastre imposat a Catalunya després de la derrota austriacista en la guerra de Successió comportà la realització de nombroses operacions de mesura de terres. Aquests treballs foren duts a terme per un petit cos d’agrimensors anomenats geòmetres del reial tribut del Cadastre. Entre 1727 i 1815 n’hem identificat un total de vint-i-dos geòmetres. La creació d’aquesta figura va fer visible una professió fins llavors força desdibuixada a Catalunya. La cartografia cadastral és modesta, però alguns d’aquests geòmetres realitzaren també mapes més elaborats amb altres finalitats. After the Austrian defeat in the War of the Spanish Succession a cadastre was imposed to Catalonia. That entailed the…
Radio environment map estimation based on communication cost modeling for heterogeneous networks
2017
Los mapas del entorno radioeléctrico pueden ser una poderosa herramienta para lograr una asignación de recursos eficiente y consciente del contexto en las redes heterogéneas 5G. En este trabajo, consideramos una red heterogénea formada por una red celular tradicional y una red de sensores inalámbricos. El papel de la red de sensores inalámbricos es estimar el mapa del entorno radioeléctrico de la célula utilizando una técnica de interpolación geoestadística denominada Kriging. En un trabajo anterior se propuso un algoritmo de agrupación distribuida de sensores para reducir la complejidad de la estimación. En nuestra contribución, el proceso de formación de clústeres se modifica para incluir…