Search results for "marker"

Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs

2014

Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…

Could PD-1/PDL1 immune checkpoints be linked to HLA signature?

2019

The outstanding clinical expansion of monoclonal antibodies (mAbs) to programmed cell death receptor-1 (PD-1) (nivolumab and pembrolizumab) and PD-1 ligand-1 (PDL-1) (atezolizumab, avelumab and durvalumab) has received an increasing level of interest regarding immunotherapy and multidrug combinations, for the treatment of a number of common human malignancies. Some patients treated with these agents receive remarkable benefits in term of quality of life, progression-free (PFS) and overall survival (OS). However, a significant percentage of these patients experience immune-related adverse events (irAEs), while others present with an ultra-rapid disease progression, defined as hyperprogressio…

Physical Performance During the Menopausal Transition and the Role of Physical Activity

2020

Abstract Background To examine longitudinal changes in physical performance during the menopausal transition and the role of physical activity (PA) in these changes. Methods Based on follicle-stimulating hormone levels and bleeding diaries, women (47–55 years) were classified as early (n = 89) and late perimenopausal (n = 143) and followed prospectively until postmenopausal status, with mean duration of 17.5 and 13.8 months, respectively. Physical performance was measured by handgrip force, knee extension torque, vertical jumping height, maximal walking speed, and 6-minute walking distance. Physical activity was self-reported and categorized as inactive, low, medium, and high. Longitudinal …

Inferring Phytoplankton, Terrestrial Plant and Bacteria Bulk δ¹³C Values from Compound Specific Analyses of Lipids and Fatty Acids.

2015

Stable isotope mixing models in aquatic ecology require δ13C values for food web end members such as phytoplankton and bacteria, however it is rarely possible to measure these directly. Hence there is a critical need for improved methods for estimating the δ13C ratios of phytoplankton, bacteria and terrestrial detritus from within mixed seston. We determined the δ13C values of lipids, phospholipids and biomarker fatty acids and used these to calculate isotopic differences compared to the whole-cell δ13C values for eight phytoplankton classes, five bacterial taxa, and three types of terrestrial organic matter (two trees and one grass). The lipid content was higher amongst the phytoplankton (…

Rye doubled haploids : production and use in mapping studies

2009

Teija Tenhola-Roininen kehitti väitöskirjatyössään rukiin jalostusta helpottavia työkaluja rukiin laadun parantamiseksi ja suomalaisiin olosuhteisiin sopeutuneiden uusien ruislajikkeiden kehittämiseksi. Näiden työkalujen, ns. DNA-merkkien avulla voidaan valita lyhytkortisia ja korkean sakoluvun omaavia eli tähkäidännänkestäviä rukiita jalostusaineistosta.Rukiinviljely on vähentynyt Suomessa erityisesti huonojen satojen ja alentuneiden EU-tukien myötä. Tästä syystä yli puolet rukiista tuodaan ulkomailta. Suurin osa suomalaisessa ruisleivässä käytettävästä ruisjauhosta on siis ulkomaista alkuperää.Viljelijöille ruis on riskialtis vilja, koska sen laatu riippuu sääolosuhteista. Syksyllä kylvet…

Internalization of novel non-viral vector TAT-streptavidin into human cells

2007

BMC Biotechnology, 7 (1)

Accumulation and effects of Cd, Pb and Zn in blackbirds (Turdus merula) along a heavy metal pollution gradient.

2009

Oxidative stress biomarkers in the copepod Limnocalanus macrurus from the northern Baltic Sea : effects of hydrographic factors and chemical contamin…

2015

Inferring phytoplankton community composition with a fatty acid mixing model

2015

Abstract. The taxon specificity of fatty acid composition in algal classes suggests that fatty acids could be used as chemotaxonomic markers for phytoplankton composition. The applicability of phospholipid-derived fatty acids as chemotaxonomic markers for phytoplankton composition was evaluated by using a Bayesian fatty acid-based mixing model. Fatty acid profiles from monocultures of chlorophytes, cyanobacteria, diatoms, euglenoids, dinoflagellates, raphidophyte, cryptophytes and chrysophytes were used as a reference library to infer phytoplankton community composition in five moderately humic, large boreal lakes in three different seasons (spring, summer and fall). The phytoplankton commu…