Search results for "mass"

showing 10 items of 9693 documents

Los titulares de la locura : análisis diferencial de la prensa escrita sobre la representación social de la enfermedad mental

2002

:PSICOLOGÍA [UNESCO]UNESCO::PSICOLOGÍAMass Communications
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Anàlisi, presència i persistència de plaguicides en rius de les principals conques mediterrànies

2014

El continu creixement demogràfic de la població en l'últim segle ha creat la necessitat d'incrementar la producció d'aliments. No obstant això, les plagues i malalties destrueixen prop de la tercera part de les collites durant la seua producció, transport i emmagatzematge. Davant aquestes circumstàncies la utilització de plaguicides que controlen l'acció de les plagues és imprescindible.[1] La utilització de productes fitosanitaris ha aportat indiscutibles beneficis econòmics ja que augmenten la productivitat agrícola, i disminueixen la mà d'obra així com també el cost dels aliments. Junt amb els avantatges derivats del seu ús agrícola, la utilització de plaguicides també ha beneficiat el c…

:QUÍMICA::Química analítica::Espectroscopía de masas [UNESCO]UNESCO::QUÍMICA::Química analítica::Espectroscopía de masas:QUÍMICA::Química analítica::Análisis cromatográfico [UNESCO]espectrometria de massesqualitat de 'aiguaUNESCO::QUÍMICA::Química analítica::Análisis cromatográficoplaguicidesQuímica ambiental
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Considering syntrophic acetate oxidation and ionic strength improves the performance of models for food waste anaerobic digestion.

2021

Current mechanistic anaerobic digestion (AD) models cannot accurately represent the underlying processes occurring during food waste (FW) AD. This work presents an update of the Anaerobic Digestion Model no. 1 (ADM1) to provide accurate estimations of free ammonia concentrations and related inhibition thresholds, and model syntrophic acetate oxidation as acetate-consuming pathway. A modified Davies equation predicted NH3 concentrations and pH more accurately, and better estimated associated inhibitory limits. Sensitivity analysis results showed the importance of accurate disintegration kinetics and volumetric mass transfer coefficients, as well as volatile fatty acids (VFAs) and hydrogen up…

ADM1Environmental EngineeringHydrogenchemistry.chemical_elementBioengineeringAcetatesModellingAmmoniachemistry.chemical_compoundBioreactorsMass transferAnaerobic digestionAnaerobiosisWaste Management and DisposalDavies equationchemistry.chemical_classificationAmmonia inhibitionRenewable Energy Sustainability and the EnvironmentOsmolar ConcentrationSyntrophic acetate oxidationGeneral MedicineRefuse DisposalAnaerobic digestionFood wastechemistryIonic strengthFoodEnvironmental chemistryPropionateMethaneBioresource technology
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Trichuris trichiura egg extract proteome reveals potential diagnostic targets and immunomodulators.

2021

The proteomic analysis was performed at the proteomics facility of SCSIE, University of Valencia (Burjassot, Spain) that belongs to ProteoRed, PRB2-ISCIII, Madrid, Spain. We also thank Dr. Tatiana Corey, Dr. Amy Beierschmitt and Dr. Pompei Bolfa for their support during sample collection.

ADULT WORMSSerum ProteinsProteomePhysiologyProteomesEggsRC955-962Egg proteinBiochemistryHeat Shock ResponseMedical ConditionsReproductive PhysiologyArctic medicine. Tropical medicineINFECTIONChlorocebus aethiopsMedicine and Health SciencesSUPEROXIDE-DISMUTASECellular Stress ResponsesImmune System ProteinsbiologySoil-transmitted helminthiasisHelminth ProteinsNEMATODEBird EggsInfectious DiseasesTrichurisCell ProcessesHelminth InfectionsProteomeFemaleAntibodyPublic aspects of medicineRA1-1270EXCRETORY-SECRETORY PRODUCTSResearch ArticleNeglected Tropical DiseasesTrichuriasisImmunologyMicrobiologyVitellogeninProtein Domainsparasitic diseasesmedicineParasitic DiseasesHEAT-SHOCK PROTEINSAnimalsHumansTrichuriasisPARASITEOvumImmunodiagnosticsMOLECULAR-CLONINGIDENTIFICATIONPublic Health Environmental and Occupational HealthBiology and Life SciencesProteinsMASS-SPECTROMETRYCell Biologymedicine.diseasebiology.organism_classificationTropical DiseasesSoil-Transmitted HelminthiasesAntigens Helminthbiology.proteinTrichuris trichiuraPLoS Neglected Tropical Diseases
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Stable isotopes covering 96-7 ka BP from stalagmite CM (Santo Tomas Cave, Cuba)

2020

We present a new speleothem trace element and stable isotope record, which extends previous paleoclimate evidence from Cuban speleothems to the last 96 ka. Stable isotope samples were micromilled at a resolution of 0.10-0.33mm, and measured using an IRMS equipped with a Gasbench. Line scans of Element/Calcium ratios of the speleothem were measured by laser ablation ICPMS and were reduced to the resolution of the stable isotope records.

AGESpeleothem sampleδ13C stackedδ13CEarth System Researchpaleoclimatologyδ18O stackedstackedCentral Americaδ18OMass spectrometer DeltaPlusXL coupled to a Gasbench IIspeleothemStable isotopes
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Micelle in fase gas: una nuova frontiera della spettroMetria di Massa

2013

AGGREGATI IN FASE GAS MICELLE TENSIOATTIVI SPETTROMETRIA DI MASSA
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Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

2022

Funder: European Commission

ALTtype 2 diabetes mellitusROC receiving operator characteristicaspartate aminotransferaseHSDLDL low-density lipoproteinUHPLC ultrahigh-performance liquid chromatographyROCHCCNon-alcoholic steatohepatitisGCPCANASHGastroenterology2-HB 2-hydroxybutanoic acid; 3-HB 3-hydroxybutanoic acid; ALT alanine aminotransferase; AST aspartate aminotransferase; CE cholesterol ester; Cer ceramide; FFA free fatty acid; FLIP Fatty Liver Inhibition of Progression; Fibrosis; GC gas chromatography; HCC hepatocellular carcinoma; HSD honest significant difference; LC lipid cluster; LDL low-density lipoprotein; LM lipid and metabolite; LMC lipid metabolite and clinical variable; LPC lysophosphatidylcholine; Lipidomics; Mass spectrometry; Metabolomics; NAFL non-alcoholic fatty liver; NAFLD non-alcoholic fatty liver disease; NAS NASH activity score; NASH non-alcoholic steatohepatitis; NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network; NRR non-rejection rate; Non-alcoholic steatohepatitis; PC(O) ether PC; PC phosphatidylcholine; PCA principal component analysis; PE phosphatidylethanolamine; QTOFMS quadrupole-time-of-flight mass spectrometry; ROC receiving operator characteristic; SAF steatosis activity and fibrosis; SM sphingomyelin; T2DM type 2 diabetes mellitus; TG triacylglycerol; UHPLC ultrahigh-performance liquid chromatographySAFSAF steatosis activity and fibrosisLM lipid and metabolitehonest significant differenceHSD honest significant differenceTG triacylglycerolnon-rejection ratecholesterol esterPCPEGC gas chromatographyfree fatty acidFLIPNASH non-alcoholic steatohepatitisNIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkBIOMARKERST2DMPE phosphatidylethanolamineLDLlipidNAFLDFFA free fatty acid2-HBMetabolomicsNAFL non-alcoholic fatty liverLMCphosphatidylcholineScience & TechnologySM sphingomyelinGastroenterology & HepatologyMass spectrometryactivitynutritional and metabolic diseasesT2DM type 2 diabetes mellitusACIDSreceiving operator characteristicdigestive system diseasesquadrupole-time-of-flight mass spectrometryLC lipid clusterlow-density lipoproteinNAS2-HB 2-hydroxybutanoic acidNAS NASH activity scoreQTOFMSether PCNRRSCORING SYSTEMprincipal component analysisgas chromatographyLC2-hydroxybutanoic acidPROGRESSIONAST aspartate aminotransferaseLMPC phosphatidylcholinePC(O)MARKERSUHPLCsteatosisTOOLImmunology and AllergyINSULIN-RESISTANCECerSMFatty Liver Inhibition of Progressionhepatocellular carcinoma2-HB 2-hydroxybutanoic acid NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatographyultrahigh-performance liquid chromatographyCELPC3-HBNAFLnon-alcoholic fatty liverTGtriacylglycerolNRR non-rejection rateLife Sciences & BiomedicineNAFLD non-alcoholic fatty liver diseaseFLIP Fatty Liver Inhibition of Progressionalanine aminotransferasemetaboliteCer ceramideCE cholesterol estersphingomyelinlysophosphatidylcholineand fibrosisALT alanine aminotransferaseInternal MedicineceramideNational Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkAST3-HB 3-hydroxybutanoic acidQTOFMS quadrupole-time-of-flight mass spectrometryPCA principal component analysisLPC lysophosphatidylcholineHepatologynon-alcoholic fatty liver diseaseand clinical variablePC(O) ether PC3-hydroxybutanoic acidFibrosisNASH activity scoreNIDDK NASH-CRNlipid clusterlipid and metabolitephosphatidylethanolamineLipidomicsLMC lipid metabolite and clinical variableFFAHCC hepatocellular carcinomaJHEP reports : innovation in hepatology
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Aminoglikozīdu klases antibiotiku sastopamība Latvijā pieejamajā medū

2017

Maģistra darbā apskatīta literatūra par aminoglikozīdu klases antibiotiku atliekvielu sastopamību medū, kā arī to izcelsmes avotiem. Izmantojot augsti efektīvo šķidruma hromatogrāfu apvienojumā ar nolidojuma laika masspektrometru, tika analizēti 49 medus paraugi no Gruzijas un 30 medus paraugi no Latvijas. Tika veikta izmantotās metodes validācija, lai pārliecinātos, ka tā atbilst Eiropas Komisijas lēmuma 2002/657/EC prasībām. Antibiotiku atliekvielu klātbūtne tika konstatēta četros medus paraugos no Gruzijas, savukārt Latvijas paraugos atliekvielas netika konstatētas.

AMINOGLIKOZĪDINOLIDOJUMA LAIKA MASSPEKTROMETRIJAAUGSTI EFEKTĪVĀ ŠĶIDRUMA HROMATOGRĀFIJASTREPTOMICĪNSMEDUSMedicīna
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An alternative conception of PM10 concentration changes after short-term precipitation in urban environment

2018

Abstract In the article, a linear model is presented which describes a reduction of PM10 mass concentration in relation to the type of precipitation and water vapour content in the air. The model was built using covariance analysis. In studies of PM10 concentration changes, the results of 247 observations were used, which were carried out in the urban area. Concentration changes were archived during short-term (30 min) convection and large-scale rainfalls. For the determination of PM10 mass concentration, the reference method was used. To describe changes in PM10 concentration in the air after precipitation, a series of linear models were created, in which the explanatory variables were: th…

ANCOVAFluid Flow and Transfer ProcessesAtmospheric ScienceEnvironmental EngineeringCoefficient of determination010504 meteorology & atmospheric sciencesTroposphereRainLinear modelMechanical EngineeringLinear modelHumidity010501 environmental sciencesParticulatesAtmospheric sciences01 natural sciencesPollutionSnowHomoscedasticityEnvironmental scienceMass concentration (chemistry)PrecipitationAerosolWater vapor0105 earth and related environmental sciencesJournal of Aerosol Science
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