Search results for "maximal"

Wild

2021

Graphical abstract

An Acute Dose of Specific Grape and Apple Polyphenols Improves Endurance Performance: A Randomized, Crossover, Double-Blind versus Placebo Controlled…

2017

International audience; Polyphenols are thought to be an interesting ergogenic aid for exercise and recovery. However, most studies regarding the effects of polyphenols investigated several days of supplementations. The present work aimed to study the effects of an acute intake of grape and apple polyphenols on the capacity to maintain intense exercise, here named endurance performance. Forty-eight physically active men (31 ± 6 years) were included in this study. During the two testing sessions, volunteers completed an endurance test at a high percentage of their maximal aerobic power and time to exhaustion was measured. Respiratory and pain parameters were also monitored. The preceding eve…

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

2016

Background: Leucocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11- year follow-up. Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by q…

On the continuous and discontinuous maximal operators

2018

Abstract In the first part of this paper we study the regularity properties of a wide class of maximal operators. These results are used to show that the spherical maximal operator is continuous W 1 , p ( R n ) ↦ W 1 , p ( R n ) , when p > n n − 1 . Other given applications include fractional maximal operators and maximal singular integrals. On the other hand, we show that the restricted Hardy–Littlewood maximal operator M λ , where the supremum is taken over the cubes with radii greater than λ > 0 , is bounded from L p ( R n ) to W 1 , p ( R n ) but discontinuous.

Hippocampal hyperexcitability is modulated by microtubule-active agent: evidence from in vivo and in vitro epilepsy models in the rat

2016

The involvement of microtubule dynamics on bioelectric activity of neurons and neurotransmission represents a fascinating target of research in the context of neural excitability. It has been reported that alteration of microtubule cytoskeleton can lead to profound modifications of neural functioning, with a putative impact on hyperexcitability phenomena. Altogether, in the present study we pointed at exploring the outcomes of modulating the degree of microtubule polymerization in two electrophysiological epileptiform activity in the rat hippocampus. To this aim, we used in vivo Maximal Dentate Activation (MDA) and in vitro hippocampal epileptiform bursting activity (HEBA) paradigms to asse…

Maximal subgroups and PST-groups

2013

A subgroup H of a group G is said r to permute with a subgroup K of G if HK is a subgroup of G. H is said to be permutable (resp. S-permutable) if it permutes with all the subgroups (resp. Sylow subgroups) of G. Finite groups in which permutability (resp. S-permutability) is a transitive relation are called PT-groups (resp. PST-groups). PT-, PST- and T-groups, or groups in which normality is transitive, have been extensively studied and characterised. Kaplan [Kaplan G., On T-groups, supersolvable groups, and maxmial subgroups, Arch. Math. (Basel), 2011, 96(1), 19-25)] presented some new characterisations of soluble T-groups. The main goal of this paper is to establish PT- and PST-versions o…

Variations of selective separability II: Discrete sets and the influence of convergence and maximality

2012

A space $X$ is called selectively separable(R-separable) if for every sequence of dense subspaces $(D_n : n\in\omega)$ one can pick finite (respectively, one-point) subsets $F_n\subset D_n$ such that $\bigcup_{n\in\omega}F_n$ is dense in $X$. These properties are much stronger than separability, but are equivalent to it in the presence of certain convergence properties. For example, we show that every Hausdorff separable radial space is R-separable and note that neither separable sequential nor separable Whyburn spaces have to be selectively separable. A space is called \emph{d-separable} if it has a dense $\sigma$-discrete subspace. We call a space $X$ D-separable if for every sequence of …

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

The Effect of Natural Allergen Exposure on the Maximal Response Plateau to Adenosine 5′-monophosphate and on Exhaled Nitric Oxide of Alveolar and Bro…

2010

Muscle cross-sectional area, force production and relaxation characteristics in women at different ages

1991

Thirty women, divided among three different age groups, i.e. 30 years (range 26–35;n = 10), 50 years (range 46–55;n = 10) and 70 years (range 66–75;n = 10) volunteered as subjects for examination of the characteristics of the muscle cross-sectional area (CSA), maximal voluntary isometric force, isometric force-time and relaxation-time of their leg extensor muscles. The CSA of the quadriceps femoris muscle in the youngest age group was slightly larger (NS) than in the middle-aged group and much larger (P<0.41) than in the oldest age group whose CSA was markedly smaller (P<0.01) than the middle-aged group. Maximal force in the youngest group was slightly greater (NS) than in the middle-aged g…