Search results for "maximum"

OPTIMIZING STOCHASTIC SUSCEPTIBILITY MODELLING FOR DEBRIS FLOW LANDSLIDES: MODEL EXPORTATION, STATISTICAL TECHNIQUES COMPARISON AND USE OF REMOTE SEN…

Il presente lavoro di ricerca è stato sviluppato al fine di approfondire approcci metodologici nell'ambito della sucscettibilità da frana. In particolare, il tema centrale della ricerca è rappresentato dal tema specifico dell'esportazione spaziale di modelli di suscettibilità nell'area mediterranea. All'interno del topic specifico dell'esportazione di modelli predittivi spaziali sono state approfondite tematiche relative all'utilizzo di differenti algoritmi o di differenti sorgenti, derivate da DEM o da coperture satellitari. The present work has been developed in order to enhance current methodological approaches within the big picture of the landslide susceptibility. In particular, the ce…

Pattern and rate of post-20 ka verticaltectonic motion around Capo Vaticanopromontory (W Calabria, Italy) based onoffshore geomorphological indicators

2013

The magnitude and rate of Late Pleistocene – Holocene vertical tectonic movements offshore Capo Vaticano (western Calabria) have been quantified on the basis of the depths of infralittoral prograding wedges (IPWs) and associated abrasion platforms formed during the stillstand of the Last Glacial Maximum (LGM). These features were identified on high-resolution reflection seismic profiles acquired along the continental shelf and upper slope around the promontory. The pattern of vertical movements of the Capo Vaticano promontory is characterized by a marked asymmetry associated with a NE-directed tilt. Removal of the non tectonic component of vertical changes using an ice-volume equivalent eus…

Measuring magnitude and rate of vertical movements in the offshore Capo Vaticano (W Calabria) using lowstand coastal prisms and wave-built terraces

2012

The magnitude and rate of vertical movements have been measured in the offshore Capo Vaticano (western Calabria) for the Late Pleistocene - Holocene on the basis of the depth of submerged coastal prism and associated wave-built terrace formed during the sea-level lowstand of the Last Glacial Maximum (LGM). Uplifted and submerged terraces have proved to be valuable recorders of vertical motion in many locations around the world (e.g. DICKINSON, 2001; WEBSTER et alii, 2004) as the depth of their tops appear to be controlled by the sea-level. In the eastern Tyrrhenian margins, depending on the hydraulic energy conditions (i.e. waves and wind-induced currents), the average water depth of terrac…

Infrared thermography assisted control for apples microwave drying

2012

A microwave based system was developed for drying of apple slices while on-line controlling their temperatures. An infrared thermography assisted control system allowed to realize temperature control by detecting the instantaneous maximum temperature among the samples under test instead of a chosen slice. The effectiveness of the system at hand in realizing temperature control both in space and in time was proven for three temperatures: 55, 65 and 75 C. Temperature fluctuations became larger both with time increasing and with rising temperature levels thus causing a negative impact on dried fruit quality. In fact apples slices dried at 75 C by microwave showed L⁄ (lightness) and white index…

Optimal Control of Dissipative Quantum Systems

2008

We study the control of finite dimensional quantum systems by external laser fields. After examining the concrete example of the diatomic molecular alignment in dissipative media, we are interested in the problem of optimal control, where the objective is to bring the system from an initial state into a given final state while minimizing a cost functional. The Pontryagin maximum principle (PMP) provides necessary conditions for optimality, by establishing that any optimal trajectory is the extremal solution of an extended problem of Hamiltonian structure. In this context, we perform the analysis of two particular systems. The first one is a dissipative 2-level system, for which we determine…

Molecular phylogeny of the Notostraca

2012

Abstract We used a combined analysis of one nuclear (28S rDNA) and three mitochondrial markers (COI, 12S rDNA, 16S rDNA) to infer the molecular phylogeny of the Notostraca, represented by samples from the six continents that are inhabited by this group of branchiopod crustaceans. Our results confirm the monophyly of both extant notostracan genera Triops and Lepidurus with good support in model based and maximum parsimony analyses. We used branchiopod fossils as a calibration to infer divergence times among notostracan lineages and accounted for rate heterogeneity among lineages by applying relaxed-clock models. Our divergence date estimates indicate an initial diversification into the gener…

Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors.

2013

International audience; BACKGROUND: Lipids A, the lipophilic partial structure of lipopolysaccharides, induce regression of several tumor types in animal models. Rather than exerting direct cytotoxic effect, these compounds trigger the immune system which in turn stimulates secretion of cytokines, and activates the inducible nitric oxide synthase, as well as immune cell infiltration of tumors. OM-174 is an analogue of lipid A with dual action on toll-like receptors 2 and 4. In an experimental model of peritoneal carcinomatosis induced in BDIX rats by intraperitoneal injection of syngeneic PROb colon cancer cells, it induced a complete regression of tumors. The present phase I trial was cond…

A Nonlinear Observer for Rotor Flux Estimation of Induction Motor Considering the Estimated Magnetization Characteristic

2017

This paper proposes a nonlinear observer for induction machine drives based on space-vector dynamic model of induction machine, expressed in state form, which presents the peculiarity of taking into consideration the magnetic saturation of the iron core. This observer is particularly suitable in order to obtain high accuracy in rotor flux estimation, in both amplitude and phase position, during working conditions characterized by varying flux, among which the most important are those during electrical losses minimization. A Lyapunov-based convergence analysis is proposed in order to suitably compute the numerical observer gain guaranteeing the convergence of the estimation error. The propos…

Molecular signaling in muscle is affected by the specificity of resistance exercise protocol

2010

Mammalian target of rapamycin and mitogen-activated protein kinase (MAPK) signaling pathways have been highlighted as important for muscle adaptations and thus, they may distinguish adaptations to different exercises. Typically, resistance exercise designed for muscle hypertrophy has moderate intensity (60-80% of one repetition maximum, 1 RM) while one prioritizing maximal strength with minor hypertrophy has a higher intensity (≥90% of 1 RM). Eight untrained men (28.4 ± 3.7 years) conducted two different bilateral leg press exercise protocols: hypertrophic (5 × 10 RM) and pure maximal strength (15 × 1 RM) in a counterbalanced, cross-over design with 1 week between exercises. Vastus laterali…

Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma : Final …

2016

Purpose Blinatumomab is a CD19/CD3 BiTE (bispecific T-cell engager) antibody construct for the treatment of Philadelphia chromosome–negative acute B-lymphoblastic leukemia. We evaluated blinatumomab in relapsed/refractory B-cell non-Hodgkin lymphoma (NHL). Patients and Methods This 3 + 3 design, phase I dose-escalation study determined adverse events and the maximum tolerated dose (MTD) of continuous intravenous infusion blinatumomab in patients with relapsed/refractory NHL. Blinatumomab was administered over 4 or 8 weeks at seven different dose levels (0.5 to 90 μg/m2/day). End points were incidence of adverse events, pharmacokinetics, pharmacodynamics, and overall response rate. Results B…