Search results for "mechanisms"
showing 10 items of 587 documents
A Theoretical and Experimental Investigation of the Spectroscopic Properties of a DNA-Intercalator Salphen-Type ZnIIComplex
2014
The photophysical and DNA-binding properties of the cationic zinc(II) complex of 5-triethylammonium methyl salicylidene ortho-phenylenediiminato (ZnL 2 + ) were investi- gated by a combination of experimental and theoretical methods. DFT calculations were performed on both the ground and the first excited states of ZnL 2 + and on its possi- ble mono- and dioxidation products, both in vacuo and in selected solvents mimicked by the polarizable continuum model. Comparison of the calculated absorption and fluores- cence transitions with the corresponding experimental data led to the conclusion that visible light induces a two-elec- tron photooxidation process located on the phenylenediimi- nato…
Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer
2022
Simple Summary Non-small cell lung cancer (NSCLC) is the second most commonly diagnosed cancer and the leading cause of cancer-related death worldwide. Clinical decision-making depends on the histological classification; however, tissue biopsy is frequently not technically feasible due to tumor location or limited tissue samples. Therefore, we propose to find clinical, molecular and histological biomarkers using a minimally invasive approach based on the analysis of the cargo of the blood extracellular vesicles. Exosomes are membranous vesicles present in several biological fluids, which carry biological information to distant tissues, regulating several tumor processes. This study aims to …
Observational constraints on the modelling of SN 1006
2011
Shedding Light on Early Stage Academic Entrepreneurship : Finnish University Researchers' View on Key Stakeholder Relations and Their Influence on th…
2020
Since the mid-1980s, along with the opening up of the Finnish economy, the pressure to commercialize university research has steadily increased in Finland. This is in line with the growing importance of innovations in an ever-globalizing world in which purely production- cost-based strategies are about to become obsolete. However, in comparison to other Nordic countries and Western European industrial countries, Finnish investments in research have fallen short in their ability to increase high-technology export levels (Kotiranta and Tahvanainen 2018). Moreover, Finnish academia faces challenges in creating university-based economic activity (Nikulainen and Tahvanainen 2013). In order to he…
Uzņēmējdarbības attīstība Limbažu novadā
2015
Uzņēmējdarbības attīstība vienmēr ir bijis aktuāls jautājums, kas īpaši populārs ir kļuvis pēdējā laikā, kad daudzi jaunie uzņēmēji, izstrādājot biznesa plānus un vēloties īstenot savas idejas, piedalās un iesaistās dažādos uzņēmējdarbības atbalsta pasākumos. Šobrīd tiek aktualizēti ne tikai vietējā mēroga, bet arī Baltijas jūras reģiona valstu un visas Eiropas mēroga atbalsta projekti dažādām uzņēmēju grupām. Limbažu novadā uzņēmējdarbības atbalsta pasākumi netiek īpaši aktualizēti, tādēļ tika veikta izpēte, lai noskaidrotu, cik lielā mērā vietējie uzņēmēji tos pārzina un arī izmanto. Aptaujājot novada uzņēmējus un analizējot viņu sniegto informāciju, tika izdarīti secinājumi par samērā pa…
A comparison of different synchronization measures in electroencephalogram during propofol anesthesia
2016
Electroencephalogram (EEG) synchronization is becoming an essential tool to describe neurophysiological mechanisms of communication between brain regions under general anesthesia. Different synchronization measures have their own properties to reflect the changes of EEG activities during different anesthetic states. However, the performance characteristics and the relations of different synchronization measures in evaluating synchronization changes during propofol-induced anesthesia are not fully elucidated. Two-channel EEG data from seven volunteers who had undergone a brief standardized propofol anesthesia were then adopted to calculate eight synchronization indexes. We computed the predi…
Songs Perceived as Relaxing : Musical Features, Lyrics, and Contributing Mechanisms
2020
How we listen to music has been changing rapidly in the last years, with online streaming becoming more predominant. Besides the gain in accessibility for the listeners, the growth of online services also affords easier access to data for musical analyses. A growing body of research has been showing that daily life music listening serves varied functions, from affect regulation to social bonding. More specifically, the reduction of stress responses is quite pertinent in the contemporary world, and recent studies have high-lighted the importance of adequate musical choices. This study aimed to identify the characteristics of music that individuals perceive as favorable to relax and to compar…
Violência, evasão e exclusão na educação superior
2019
The present text focuses on a relationship between higher education, institutional and symbolic violence and exclusion, practicing as a challenge based on reflections on the existence of evasion in Brazilian university. Ignoring the educational institution as a direct responsible for these things, this text considers that a logic in University organization and operation helps to enlarge inequalities that provide the mechanisms of evasion; at the same time, it presents itself as a space of reference and a struggle against social inequalities and violence. On a provisional basis, the text stands out that: depending on the execution of educational procedures and practices undertaken by the ins…
Tractional Motion Machines extend GPAC-generable functions
2012
In late 17th century there appeared the Tractional Motion instruments, mechanical devices which plot the curves solving differential equations by the management of the tangent. In early 20th century Vannevar Bush’s Differential Analyzer got the same aim: in this paper we’ll compare the Differential Analyzer mathematical model (the Shannon’s General Purpose Analog Computer, or GPAC) with the Tractional Motion Machine potentials. Even if we will not arrive in defining the class of the functions generated by Tractional Motion Machines, we’ll see how this class will strictly extend the GPAC-generable functions.
Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy
2015
ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.