Search results for "mediator"
showing 10 items of 339 documents
What effect can manual therapy have on a patient's pain experience?
2015
Manual therapy (MT) is a passive, skilled movement applied by clinicians that directly or indirectly targets a variety of anatomical structures or systems, which is utilized with the intent to create beneficial changes in some aspect of the patient pain experience. Collectively, the process of MT is grounded on clinical reasoning to enhance patient management for musculoskeletal pain by influencing factors from a multidimensional perspective that have potential to positively impact clinical outcomes. The influence of biomechanical, neurophysiological, psychological and nonspecific patient factors as treatment mediators and/or moderators provides additional information related to the proces…
Unità operative per la scuola primaria: storia del bruco che imparò a volare.
2012
Unità operative per la scuola dell'infanzia: storia delle palline; storia di un semino; palloncino gonfia-sgonfia.
2012
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties
2021
The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We furth…
Pharmacology of Ischemia-Reperfusion. Translational Research Considerations.
2016
Ischemia-reperfusion (IRI) is a complex physiopathological mechanism involving a large number of metabolic processes that can eventually lead to cell apoptosis and ultimately tissue necrosis. Treatment approaches intended to reduce or palliate the effects of IRI are varied, and are aimed basically at: inhibiting cell apoptosis and the complement system in the inflammatory process deriving from IRI, modulating calcium levels, maintaining mitochondrial membrane integrity, reducing the oxidative effects of IRI and levels of inflammatory cytokines, or minimizing the action of macrophages, neutrophils, and other cell types. This study involved an extensive, up-to-date review of the bibliography …
Diet and Inflammation: Possible Effects on Immunity, Chronic Diseases, and Life Span
2015
Chronic inflammation negatively impacts all physiological functions, causing an array of degenerative conditions including diabetes; cancer; cardiovascular, osteo-articular, and neurodegenerative diseases; autoimmunity disorders; and aging. In particular, there is a growing knowledge of the role that gene transcription factors play in the inflammatory process. Obesity, metabolic syndrome, and diabetes represent multifactorial conditions resulting from improper balances of hormones and gene expression. In addition, these conditions have a strong inflammatory component that can potentially be impacted by the diet. It can reduce pro-inflammatory eicosanoids that can alter hormonal signaling ca…
Frailty syndrome is associated with changes in peripheral inflammatory markers in prostate cancer patients undergoing androgen deprivation therapy.
2019
To evaluate the role of peripheral inflammation (leukocyte differential count, the proinflammatory cytokines IL-beta, TNF-α, IL-6, IL-8, and the inflammatory markers fibrinogen and C-reactive protein [CRP]) in frailty syndrome in patients with prostate cancer (CaP) undergoing antiandrogen therapy (ADT).A total of 46 men between 51 and 92 years of age with CaP and receiving ADT were classified as frail, prefrail or robust according to the Fried scale. A geriatric assessment was performed, based on the Minimental State Examination for cognitive function, the Barthel index for basic activities of daily living, the Yesavage scale for geriatric depression, and the Athens insomnia scale. In addit…
Lipid rafts: a signalling platform linking lipoprotein metabolism to atherogenesis.
2012
Lipid rafts are microdomains of the plasma membrane which are enriched in cholesterol and sphingolipids. They serve as a platform for signal transduction, in particular during immune and inflammatory responses. As hypercholesterolemia and inflammation are two key elements of atherogenesis, it is conceivable that the cholesterol and cholesterol oxide content of lipid rafts might influence the inflammatory signalling pathways, thus modulating the development of atherosclerosis. In support of this emerging view, lipid rafts have been shown to be involved in several key steps of atherogenesis, such as the oxysterol-mediated apoptosis of vascular cells, the blunted ability of high density lipopr…
"Intermediate SR cutflow efficiencies" of "Search for dark matter produced in association with a dark Higgs boson decaying into $W^\pm W^\mp$ or $ZZ$…
2020
Cumulative efficiencies for the intermediate category for signal samples with ms=160 GeV (a), ms=235 GeV (b) and ms=310 GeV (c), each with mZ'=1 TeV. The TAR+Comb algorithm reconstructs the dark Higgs candidate from a TAR jet with mTAR>60 GeV that is supplemented by up to two additional small-R jets within ΔRcone=2.5 of the TAR jet. Here, Δ φjets1,2,3 ETmiss is the smallest azimuthal angle between the ETmiss and any of the three highest-pT (leading) small-R jets. For details see text.
"Merged SR cutflow efficiencies" of "Search for dark matter produced in association with a dark Higgs boson decaying into $W^\pm W^\mp$ or $ZZ$ in fu…
2020
Cumulative efficiencies for the merged category for signal samples with ms=160 GeV (a), ms=235 GeV (b) and ms=310 GeV (c), each with mZ'=1 TeV. The dark Higgs candidate selection includes stringent jet substructure requirements and typically at most one candidate is present in signal events. Here, Δ φjets1,2,3 ETmiss is the smallest azimuthal angle between the ETmiss and any of the three highest-pT (leading) small-R jets.