Search results for "mediators"
showing 10 items of 245 documents
Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach.
2006
Clinically and pathologically Alzheimer's disease (AD) represents a sequential progressive neurodegenerative disorder. AD is etiologically heterogeneous and accounts for a majority of dementia in western societies. Inflammation clearly occurs in pathologically vulnerable regions of the AD brain and the search for genetic factors influencing the pathogenesis of AD has lead to the identification of numerous gene polymorphisms that might act as susceptibility modifiers. Accordingly, several reports have indicated that the risk of AD is substantially influenced by several genetic polymorphisms in the promoter region, or other untranslated regions, of genes encoding inflammatory mediators, altho…
Known knowns and known unknowns on behavior change interventions and mechanisms of action.
2020
Systematic reviews and meta-analyses of research play an important role in summarizing current knowledge on the efficacy of the behavior change techniques and mechanisms of action that comprise behavioral interventions. The current reviews in the science of behavior change (SOBC) special issue represent a ‘step change’ in evaluating current evidence on behavior change interventions and mechanisms. This concluding article outlines the key findings and emerging issues identified in the reviews (‘known knowns’), and summarizes the evidence gaps highlighted by the reviews that need to be addressed in future research (‘known unknowns’). Specifically, findings of the reviews indicate that: tests …
Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside.
2007
We have studied scrovalentinoside, an iridoid with anti-inflammatory properties isolated from Scrophularia auriculata ssp. pseudoauriculata, as an anti-inflammatory agent in different experimental models of delayed-type hypersensitivity. We found that scrovalentinoside reduced the edema induced by oxazolone at 0.5 mg/ear and sheep red blood cells at 10 mg/kg. The observed effect occurred during the last phase or inflammatory response; during the earlier phase or induction of the delayed-type hypersensitivity reaction, no significant activity was noted. Thus, scrovalentinoside reduced both the edema and cell infiltration in vivo and reduced lymphocyte proliferation in vitro, affecting the cy…
Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Age…
2010
Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade s…
Médiateurs linguistiques et culturels dans l'ile de Lampedusa: une enquete
2020
The island of Lampedusa, in Sicily, has been in the news for years because of the landings of migrants (especially Africans). Our study is based on interviews with cultural mediators who work with NGOs and other hosting humanitarian organizations based on this extreme land of Europe. We intend to verify, through our interviews, what are the major cultural problems (Katan 2014 [1999]) in translation, the level of manipulation and the risks that translators must assume to accomplish their task.
Recent Probes of Standard and Non-standard Neutrino Physics With Nuclei
2019
We review standard and non-standard neutrino physics probes that are based on nuclear measurements. We pay special attention on the discussion of prospects to extract new physics at prominent rare event measurements looking for neutrino-nucleus scattering, such as the coherent elastic neutrino-nucleus scattering (CE$\nu$NS) that may involve lepton flavor violation (LFV) in neutral-currents (NC). For the latter processes several appreciably sensitive experiments are currently pursued or have been planed to operate in the near future, like the COHERENT, CONUS, CONNIE, MINER, TEXONO, RED100, vGEN, Ricochet, NUCLEUS etc. We provide a thorough discussion on phenomenological and theoretical studi…
Different Efficiency of Heat Shock Proteins (HSP) to Activate Human Monocytes and Dendritic Cells: Superiority of HSP60
2002
Abstract One essential immunoregulatory function of heat shock protein (HSP) is activation of the innate immune system. We investigated the activation of human monocytes and monocyte-derived dendritic cells (DC) by recombinant human HSP60, human inducible HSP72, and preparations of human gp96 and HSP70 under stringent conditions, in the absence of serum and with highly purified monocytes. HSP60 induced human DC maturation and activated human DC to secrete proinflammatory cytokines. HSP72 induced DC maturation to a lesser extent, but activated human monocytes and immature DC as efficiently as HSP60 to release proinflammatory cytokines. The independence of the effects of HSP60 and HSP72 from …
Side-specific effects by cadmium exposure: Apical and basolateral treatment in a coculture model of the blood–air barrier
2010
Cadmium (Cd{sup 2+}) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was cultured with the endothelial cell line, ISO-HAS-1, as a bilayer on a 24-well HTS-Transwell (registered) filter plate. This coculture model was exposed to various concentrations of CdCl{sub 2}. The transepithelial electrical resistance decreased on the apical side only after treatment with high Cd{sup 2+} concentrations after 48 h. By contrast, a breakdown of TER to less t…
Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins
2012
Amorphous silica nanoparticles (aSNPs) gain increasing popularity for industrial and therapeutic claims. The lung with its surface area of 100-140 m(2) displays an ideal target for therapeutic approaches, but it represents also a serious area of attack for harmful nanomaterials. The exact nature of the cytotoxic effects of NPs is still unknown. Furthermore, cellular pathways and the destiny of internalized NPs are still poorly understood. Therefore, we examined the cytotoxicity (MTS, LDH) and inflammatory responses (IL-8) for different-sized aSNPs (30, 70, 300 nm) on our lung epithelial cells line NCI H441 and endothelial cell line ISO-HAS-1. Additionally, colocalization studies have been c…
Short‐term hypoxia promotes vascularization in co‐culture system consisting of primary human osteoblasts and outgrowth endothelial cells
2019
Prevascularization of tissue constructs before implantation has been developed as a novel and promising concept for successful implantation. Since hypoxia might induce angiogenesis, we have investigated the effects of hypoxic treatment on vascularization by using co-cultures of primary human osteoblasts (POBs) and outgrowth endothelial cells. Our results show that: (a) repeated short-term hypoxia (2% O2 for 8 hr), not long-term hypoxia (2% O2 for 24 hr), over 1 or 2 weeks, significantly enhances microvessel formation in co-cultures; (b) sustained hypoxia, not short-term or long-term hypoxia, causes cytotoxicity in mono- and co-cultures; (c) the expression of some angiogenic and inflammatory…