Search results for "medical applications"
showing 8 items of 18 documents
Biomaterials for Biotechnological and Pharmaceutical application
2010
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
2017
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence o…
Design, Microfabrication and Characterization of a Power Delivery System for new Biomedical Applications
2017
This paper presents the design, microfabrication and characterization of a wireless power delivery system capable of driving a surface acoustic wave sensor (SAW) for biomedical applications. The system consists of two planar, spiral-square microcoils, which have been geometrically optimized in order to maximize the quality factor Q. The integration of the SAW - microcoil system into artificial implant sites will allow a real-time biofilm growth monitoring and treatment, providing countless advantages to the related medical applications.
Xyloglucan self-assembled nanostructures and gels for biomedical applications
Inulin vinyl sulfone derivative cross-linked with bis-amino PEG: new materials for biomedical applications
2009
In this work new hydrogels based on biocompatible polymers such as inulin (INU) and O,O'-bis(2-aminoethyl)polyethyleneglycol (PEGBa) have been prepared and charaterized. In particular, INU has been derivatized with divinyl sulfone (DV) thus obtaining the INUDV derivative, a copolymer bearing double bonds highly reactive towards the conjugate addition by nucleophilic molecules. INUDV has been characterized by FT-IR, 1 H-NMR and SEC analyses that have confirmed the success of the derivatization reaction. With the aim to obtain novel hydrogel systems, INUDV derivative has been cross-linked with PEGBa in phosphate buffer solution pH 7.4. The reaction has been carried out for 4 h at room tempera…
Oligonucleotides-decorated-poly(N-vinyl pyrrolidone) nanogels for gene delivery
2013
Pulsed electron-beam irradiation of a semi-dilute poly(N-vinyl pyrrolidone) (PVP) aqueous solution in the presence of acrylic acid has led to a carboxyl functionalized nanogel system. Nanoparticles hydrodynamic size and surface charge density, in water and as a function of pH, were investigated by dynamic light scattering and laser doppler velocimetry, respectively. Nanogels (NGs) were proved not to be cytotoxic at the cellular level. Indeed, they rapidly bypass the cellular membrane to accumulate in specific cell portions of the cytoplasm, in the perinuclear area. The availability of pendant carboxyl groups on the crosslinked PVP NGs core prompted us to attempt their decoration with a sing…
Purification of Nano-Porous Silicon for Biomedical Applications
2011
Recently, various bio-medical applications of nanoporous silicon (np-Si) have been suggested. This work investigates the biocompatibility of np-Si particles taking into account hazardous residua confined in the pores after preparation. The emphasis is on the potential application of such particles as oxygen photosensitizer for photodynamic therapy of cancer, which requires both negligible toxicity of np-Si particles in darkness and a high photo-cyto-toxic effect due to generation of singlet oxygen under illumination. Considerable amounts of water soluble toxic impurities are found to be present in the nanoporous shell of micrometer-sized np-Si particles immediately after their preparation b…
Tissue Engineering Biopolymers
2011
Tissue engineering has always been a multidisciplinary research area focused on tissue regeneration and restoration of organs function, through implantation of cells or tissues growing outside the body. According to increase in knowledge of the interactions between living organisms and biomaterials, development and diversification of biocompatible devices has brought the world of medicine to what has been the greatest therapeutic revolution of our times. The main challenge of biomaterials is not only related to "tolerance-biocompatibility" by the body but also in its functionality. A biomaterial must be able to positively interact with tissues and exercise those functions for which it was d…