Search results for "medical sciences"
showing 10 items of 208 documents
Supplementary information files for Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countrie…
2020
Supplementary files for article Supplementary information files for Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants.BackgroundComparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.MethodsFor this pooled analysis, we used a database of cardiometabolic risk factors collated by the…
Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an anti-apoptotic viral gene
2008
ABSTRACT Genes that inhibit apoptosis have been described for many DNA viruses. Herpesviruses often contain even more than one gene to control cell death. Apoptosis inhibition by viral genes is postulated to contribute to viral fitness, although a formal proof is pending. To address this question, we studied the mouse cytomegalovirus (MCMV) protein M36, which binds to caspase-8 and blocks death receptor-induced apoptosis. The growth of MCMV recombinants lacking M36 (ΔM36) was attenuated in vitro and in vivo. In vitro, caspase inhibition by zVAD-fmk blocked apoptosis in ΔM36-infected macrophages and rescued the growth of the mutant. In vivo, ΔM36 infection foci in liver tissue contained sign…
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.
2013
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with List…
Obesity in Aging and Art
2009
THIS issue of Journal of Gerontology: Medical Sciences highlights new findings on obesity in older persons and its consequences for health and function (1,2,3). The obesity epidemic is spreading rapidly in both developed and developing countries, and perspectives on the negative effects of overweight and obesity abound in recent medical literature. What do we know so far about obesity over the lifetime? Obesity does not spare older persons (4). Obese older persons experience a wide range of negative consequences, including metabolic abnormalities, arthritis, pulmonary diseases, cataracts, cancer, impaired mobility, disability, and mortality. Given the already extensive knowledge base, why a…
Sleep-Related Factors and Mobility in Older Men and Women
2010
SHORT and long sleep duration, sleep-related disturbances, and their daytime consequences are common in older adults, and they are associated with decreased health and increased mortality (1–4). Because aging is associated with decline in physical performance often leading to physical disability and loss of independence, concomitant sleep problems may exacerbate the age-related decline in physical function. Previous studies suggest that self-reported and measured insomnia and sleep-related problems are associated with decline in psychomotor performance (5) as well as with poor balance and increased risk of falls (6–8). In addition, Goldman and coworkers (2007) (9) reported that short (<6 ho…
Primary stroke prevention worldwide:translating evidence into action
2021
Abstract: Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, includin…
Luftverschmutzung als wichtiger Kofaktor bei COVID-19-Sterbefällen
2021
Zusammenfassung Hintergrund Die Sterblichkeit bei COVID-19 ist in Anwesenheit kardiopulmonaler Komorbiditäten erhöht. Luftverschmutzung ist ebenfalls mit einer erhöhten Sterblichkeit assoziiert, v. a. vermittelt durch kardiopulmonale Erkrankungen. Beobachtungen zu Beginn der COVID-19-Pandemie zeigten, dass die Sterblichkeit bei COVID-19 v. a. in Regionen mit stärkerer Luftverschmutzung erhöht ist. Ungeklärt ist der Einfluss von Luftverschmutzung für den Krankheitsverlauf bei COVID-19. Methode Es wurde eine selektive Literaturrecherche von Studien bis Anfang April 2021 in PubMed zum Zusammenhang von Luftverschmutzung und der COVID-19-Mortalität mit den Suchbegriffen „air pollution AND/OR COV…
Veränderung des Schmeckvermögens bei Patienten mit Vestibularisschwannom
2014
Das Vestiularisschwannom ist ein gutartiger Tumor. Klinisch wird die Erkrankung durch die Kardinalsymptome einseitige Hörminderung, Tinnitus und Gleichgewichtsstörungen auffällig. Auf Grund der anatomischen Enge im Bereich des inneren Gehörganges kann es auch zu Affektionen des N.[for full text, please go to the a.m. URL]
Hepatitis B subviral envelope particles use the COPII machinery for intracellular transport via selective exploitation of Sec24A and Sec23B
2020
Hepatitis B virus (HBV) is a leading cause of liver disease. Its success as a human pathogen is related to the immense production of subviral envelope particles (SVPs) contributing to viral persistence by interfering with immune functions. To explore cellular pathways involved in SVP formation and egress, we investigated host-pathogen interactions. Yeast-based proteomics revealed Sec24A, a component of the coat protein complex II (COPII), as an interaction partner of the HBV envelope S domain. To understand how HBV co-opts COPII as a proviral machinery, we studied roles of key Sec proteins in HBV-expressing liver cells. Silencing of Sar1, Sec23, and Sec24, which promote COPII assembly conco…
Is large-scale rapid CoV-2 testing a substitute for lockdowns?
2021
Background Various forms of contact restrictions have been adopted in response to the Covid-19 pandemic. Around February 2021, rapid testing appeared as a new policy instrument. Some claim it may serve as a substitute for contact restrictions. We study the strength of this argument by evaluating the effects of a unique policy experiment: In March and April 2021, the city of Tübingen set up a testing scheme while relaxing contact restrictions. Methods We compare case rates in Tübingen county to an appropriately identified control unit. We employ the synthetic control method. We base interpretations of our findings on an extended SEIR model. Findings The experiment led to an increase in the …