Search results for "medicinal"

Equilibrium and spectroscopic studies of diethyltin(iv) complexes formed with hydroxymono- and di-carboxylic acids and their thioanalogues

2002

The complex formation of diethyltin(IV) cation with glycolic (GA), lactic (LA), succinic (SA), malic (MA), tartaric (TA), mercaptoacetic (MAA), 2-mercaptopropionic (MPA), mercaptosuccinic (MSA) and dimercaptosuccinic acid (DMSA) has been investigated by potentiometric, spectrophotometric, 1H NMR and Mossbauer spectroscopic methods. The mercaptocarboxylic acids yielded much more stable complexes than the corresponding hydroxy acids. Below pH 3, the carboxylate and the still protonated hydroxyl group of hydroxy acids are co-ordinated to the metal ion, while in the case of their thio analogues, {COO−, S−} co-ordinated species are dominant. With increasing pH, the metal promoted deprotonation o…

Silicon-guided rearrangement of 10-methyl-4,5-epoxydecalins. Methyl versus methylene migration

2003

The Lewis acid-promoted rearrangement of two 10-methyl-4,5-epoxydecalins bearing a trimethylsilyl (TMS) group on C-1 or C-9 has been studied. Migration of the C-9 methylene group to C-5 is the major reaction pathway when the TMS and the oxirane groups are on the same ring while methyl migration results exclusively when they are on different rings.

A New Versatile Synthesis of N,N′,N″,N″′-Tetra-(2-carboxyethyl)-and N,N′,N″,N″′-Tetra-(3-aminopropyl)-tetraazacycloalkanes by Michael Addition of Pol…

1996

Abstract A smooth and convenient one step synthesis of N,N′,N″,N″′-tetra-(2-carboxyethyl)-tetraazacycloalkanes is reported. These compounds are synthesized by Michael addition of tetraazacycloalkanes to acrylic acid. The same Michael addition of tetraazacycloalkanes to an excess of acrylonitrile also leads to the corresponding tetracyanoethylated derivatives. The reduction of such tetracyanoethylated compounds is a new way of preparation for the corresponding primary amines.

Understanding the Intramolecular Diels-Alder Reactions of N-Substituted N-Allyl-Furfurylamines: An MEDT Study

2017

ChemInform Abstract: Synthesis and Antiproliferative Activity of Novel 3-(Indazol-3-yl)-quinazolin-4(3H)-one and 3-(Indazol-3-yl)-benzotriazin-4(3H)-…

2010

Several new 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3-yl)-benzotriazin-4(3H)-one derivatives 5 and 6 were synthesized and tested for their in vitro antiproliferative activity against Raji, K562, and K562-R cell lines. The pharmacological screening showed that some 2, 6, or 7-substituted quinazolinones 5 posses a significant antiproliferative activity, with a percentage growth inhibition ranging from 44.8% to 100% at 50 microM, which was higher than that showed by the unsubstituted derivative 5a previously synthesized. For the most active compounds 5d, 5f, and 5g the IC50 were recorded.

Antibakterielle Wirkstoffe, 10. Mitt. 2-(Methylthioanilino)pyrimidine

1985

Tumorhemmende Wirkstoffe, 12. Mitt. 2-Ureido-4(3H)-pyrimidinone

1981

Aus der Kondensation von Guanidincarbonsaureamid (1) mit den β-Ketocarbonsaureestern 2a–h resultieren die 2-Ureido-4(3H)-pyrimidinone 3a–h. Die Ubertragbarkeit dieser Reaktionsweise auf cyclische Ketocarbonsaureester geht aus der zu 2-Ureido-5,6,7,8-tetrahydro-4(3 H)-chinazolon (3i) fuhrenden Kondensation von 1 mit 2-Oxocyclohexancarbonsaureethylester (2i) hervor. Besonders 3h vermag turmorhemmende Effekte auszulosen. Tumor Inhibitory Agents, XII: 2-Ureido-4(3H)-pyrimidinones The condensation of guanidinecarboxylic amide (1) with the β-ketocarboxylates 2a-h leads to the 2-ureido-4(3H)-pyrimidinones 3a–h. The applicability of this reactin to cyclic ketocarboxylates is demonstrated by the con…

ChemInform Abstract: Rhodium(III)-Catalyzed Ring-Opening of Strained Olefins Through C-H Activation of O-Acetyl Ketoximes: An Efficient Synthesis of …

2014

An efficient strategy for the stereoselective synthesis of functionalized cyclopentenes and spiro[2.4]heptenes from strained olefins via C–H activation of aryl ketone O-acetyl ketoximes using [RhCl2Cp∗]2 catalyst is described. The results revealed that a wide range of readily accessible aryl and heteroaryl ketoximes are compatible in this method for the ring opening of bicyclic and spirotricyclic olefins.

Polycondensed nitrogen heterocycles. Part24. Pyrrolo[3,4-c]isoquinolinone by thermal rearrangement of a pyrrolylbenzotriazinone

1992

Rearrangement under acidic conditions of the pyrrolylbenzotriazinone 7 afforded the pyrrolylbenzamides 10 and 11. By thermal rearrangement instead, the first fully aromatic derivative of the pyrrolo[3,4-c]isoquinoline ring system 9 was obtained.

Reaktivitäut und reaktionswege von methylsubstituierten bisindolylcarbenium-ionen

1987

Methyl substituted bisindolylcarbenium ions 1 react with some O- and C-nucleophiles regioselectively. The cations 1b, 1c yield with hydroxide ions the tetraindolyldimethyl ether 4 and with methoxide ions the bisin-dolylmethoxymethanes 5. Compounds 1a, 1b, 1c react with several methylindoles to isomeric bis- and trisin-dolylmethanes. An electrophilic reactivity order of cations 1 can be derived supporting on the experimental results.