Search results for "medium"
showing 10 items of 3746 documents
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Metal-Organic Nanocapsules with Functionalized s-Heptazine Ligands.
2020
A metalloorganic capsule was synthesized where the ligand is a derivative of heptazine with three carboxylic groups that are coordinated to CuII cations, forming paddle-wheel motifs. Each nanocapsule is neutral, with 12 CuII centers and 8 ligands adopting a rhombicuboctahedron shape. It has almost 3 nm diameter, and the main intermolecular interactions in the solid are π··· π stacking between the C6N7 heptazine moieties. The nanocapsules can form monolayers deposited on graphite as observed by atomic force microscopy, which confirms their stability in solution. peerReviewed
Laser heterodyne displacement measuring using PLZT frequency shifter
1991
Abstract The implementation of a frequency shifter based on lead lanthanum zirconate titanate ceramic (PLZT) and a voltage-controlled λ/4 plate is described. The capabilities of these elements are demonstrated with results from a Michelson-type laser heterodyne displacement measuring interferometer with 0.01 μm accuracy and 1 Hz display update rate.
The oxamate route, a versatile post-functionalization for metal incorporation in MIL-101(Cr): Catalytic applications of Cu, Pd, and Au
2013
Abstract A new consecutive post-functionalization method has been developed for the inclusion of additional metal functionalities in Metal Organic Frameworks (MOFs) through oxamate as chelating agent. This may result in catalytic centers of metal–organic complexes or in controlled formation of metal nanoparticles, demonstrated for Cu, Pd and Au, in the highly stable MIL-101(Cr) framework. In a first post-synthesis step, reduction of the NO 2 -MIL-101(Cr) leads to the formation of NH 2 -MIL-101(Cr). The second functionalization consists of a straightforward condensation of the amino groups of the ligand with ethyl chloro-oxoacetate resulting in the formation of free oxamates attached to the …
p -Type and n -type conductometric behaviors of octachloro-metallophthalocyanine-based heterojunctions, the key role of the metal
2020
In the present work, we determined the electrical properties of octachlorinated metallophthalocyanines with Co(II) and Cu(II) ions as metal centers. We engaged them in heterojunctions, with lutetium bisphthalocyanine as a partner. Surprisingly, cobalt and copper complexes show opposite behaviors, the first being an [Formula: see text]-type material whereas the latter is a [Formula: see text]-type material, as deduced from the response of the heterojunctions towards ammonia; showing the unusual key role played by the metal center. While the LuPc[Formula: see text]/Cu(Cl[Formula: see text]Pc) complex exhibits a negative response to ammonia, the LuPc[Formula: see text]/Co(Cl[Formula: see text…
The chemical signature of jet-driven hypernovae
2020
Hypernovae powered by magnetic jets launched from the surface of rapidly rotating millisecond magnetars are one of the leading models to explain broad-lined Type Ic supernovae (SNe Ic-BL), and have been implicated as an important source of metal enrichment in the early Universe. We investigate the nucleosynthesis in such jet-driven hypernovae using a parameterised, but physically motivated, approach that analytically relates an artificially injected jet energy flux to the power available from the energy in differential rotation in the proto-neutron star. We find ejected $^{56}\mathrm{Ni}$ masses of $0.05\,\mathrm{M}_\odot - 0.45\,\mathrm{M}_\odot$ in our most energetic models with explosion…
XMM-Newton Large Program on SN1006 - I: Methods and Initial Results of Spatially-Resolved Spectroscopy
2015
Based on our newly developed methods and the XMM-Newton large program of SN1006, we extract and analyze the spectra from 3596 tessellated regions of this SNR each with 0.3-8 keV counts $>10^4$. For the first time, we map out multiple physical parameters, such as the temperature ($kT$), electron density ($n_e$), ionization parameter ($n_et$), ionization age ($t_{ion}$), metal abundances, as well as the radio-to-X-ray slope ($\alpha$) and cutoff frequency ($\nu_{cutoff}$) of the synchrotron emission. We construct probability distribution functions of $kT$ and $n_et$, and model them with several Gaussians, in order to characterize the average thermal and ionization states of such an extended s…
Searching for pulsed emission from XTE J0929-314 at high radio frequencies
2009
The aim of this work is to search for radio signals in the quiescent phase of accreting millisecond X-ray pulsars, in this way giving an ultimate proof of the recycling model, thereby unambiguously establishing that accreting millisecond X-ray pulsars are the progenitors of radio millisecond pulsars. To overcome the possible free-free absorption caused by matter surrounding accreting millisecond X-ray pulsars in their quiescence phase, we performed the observations at high frequencies. Making use of particularly precise orbital and spin parameters obtained from X-ray observations, we carried out a deep search for radio-pulsed emission from the accreting millisecond X-ray pulsar XTE J0929-31…
ROLE OF EJECTA CLUMPING AND BACK-REACTION OF ACCELERATED COSMIC RAYS IN THE EVOLUTION OF TYPE Ia SUPERNOVA REMNANTS
2012
We investigate the role played by initial clumping of ejecta and by efficient acceleration of cosmic rays (CRs) in determining the density structure of the post-shock region of a Type Ia supernova remnant (SNR) through detailed 3D MHD modeling. Our model describes the expansion of a SNR through a magnetized interstellar medium (ISM), including the initial clumping of ejecta and the effects on shock dynamics due to back-reaction of accelerated CRs. The model predictions are compared to the observations of SN 1006. We found that the back-reaction of accelerated CRs alone cannot reproduce the observed separation between the forward shock (FS) and the contact discontinuity (CD) unless the energ…
Osmotic conditions in rheologic properties of erytrocites
2001
Abstract The decreasing viability and in vivo survival of red blood cells, RBCs, observed in blood bank-storage are due to alterations in their rheologic properties and metabolic status. However, there is a lack of electrokinetic experiments with erythrocytes by the screening produced by the high concentration of buffer required to keep the isoosmotic conditions. Electrokinetic measurements in a wide range of sodium chloride and tetrasodium pyrophosphate are undertaken on liposomes as cell models, and in order to get an aqueous media suitable for maintaining osmotic conditions and allowing electrophoretic mobility measurements as well, advantage has been taken of dextrose properties. Measur…