Search results for "mek"
showing 10 items of 844 documents
Analysing effectiveness of force application in ski skating using force and motion capture data : a model to support cross-country skiing research an…
2014
Maastohiihto on huomattavan vaativaa kokovartaloliikuntaa niin fysiologian kuin biomekaniikankin kannalta tarkasteltuna. Latujen kunnostuksen, hiihtovälineiden, hiihtotekniikoiden sekä kilpailumuotojen kehityksen myötä hiihdosta on tullut nopeampaa ja vaativampaa, joka asettaa suurempia haasteita voimantuotolle. Vastaavasti hiihtotutkimuksessa huomio on viime vuosikymmeninä siirtynyt enemmän biomekaniikan suuntaan. Ensimmäiset ulkoisten suksi- ja sauvavoimien mittaukset suoritettiin yli kolmekymmentä vuotta sitten ja useita yhteyksiä voimantuoton ominaisuuksien ja hiihtosuorituskyvyn välillä on sittemmin tunnistettu. Edelleen on kuitenkin epäselvää mitkä ovat tärkeimmät voimamuuttujat kuvaa…
Magnētiskās rezonanses attēlu kvalitātes izvērtēšana temporomandibulāro locītavu izmeklējumos pacientiem ar juvenilu idiopātisko artrītu
2017
Bakalaura darba tēma “Magnētiskās rezonanses attēlu kvalitātes izvērtēšana temporomandibulāro locītavu izmeklējumos pacientiem ar juvenilo idiopātisko artrītu”. Tēmas aktualitāte balstās uz to, ka magnētiskās rezonanses izmeklējums ar kontrastvielas ievadi ir kā zelta standarts, lai izmeklētu žokļa locītavas, pacientiem ar šo locītavu iekaisīgām slimībām. Lielai daļai juvenila idiopātiska artrīta pacientu, iekaisums skar šīs locītavas, taču norise var būt asimptomātiska vai ar minimāliem simptomiem, radot izteiktu locītavas bojājumu. Darba mērķis ir izvērtēt magnētiskās rezonanses temporomandibulāro locītavu izmeklējumu attēlu kvalitāti. Pētniecības uzdevumi ir, balstoties uz literatūras un…
Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer
2015
BACKGROUND: The mitogen-activated protein kinase (MAPK) pathway has been implicated in the molecular pathogenesis of human cancers, including metastatic colorectal cancer (mCRC). This provides a rationale for the development of MAPK-targeted agents such as pimasertib. METHODS: Patients with KRAS mutant mCRC were treated in the second-line setting with FOLFIRI (5-fluorouracil/folinic acid/irinotecan) plus pimasertib. The primary objective of the safety run-in phase was to determine the maximum-tolerated dose (MTD) and the recommended phase II dose of pimasertib combined with FOLFIRI. RESULTS: Sixteen patients were enrolled in the trial. Ten and six patients were treated daily with 45 and 60 …
Effect of biomechanical footwear on upper and lower leg muscle activity in comparison with knee brace and normal walking
2021
Abstract Aim To evaluate the activity of knee stabilizing muscles while using custom-made biomechanical footwear (BF) and to compare it when walking barefoot and with a knee brace (Unloader®). Methods Seventeen healthy working-aged (mean age: 29 years; standard deviation: 8 years) individuals participated. The knee brace was worn on the right knee and BF in both legs. Surface electromyography (sEMG) data was recorded bilaterally from vastus medialis (VM), semitendinosus (ST), tibialis anterior (TA) and lateral gastrocnemius (LG) muscles during walking, and repeated-measures ANOVA with a post-hoc t-test was used to determine differences between the different walking modalities (barefoot, bra…
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mtor pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
2011
Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described …
Phosphorylation of extracellular signal-related protein kinase is required for rapid facilitation of heat-induced currents in rat dorsal root ganglio…
2005
A subgroup of dorsal root ganglion (DRG) neurons responds to noxious heat with an influx of cations carried by specific ion channels such as the transient receptor potential channel of the vanilloid receptor type, subtype 1 (TRPV1). Application of capsaicin induces a reversible facilitation of these currents. This facilitation could be an interaction of two agonists at their common receptor or be caused by an influx of calcium ions into the cell. Calcium influx into the cell can activate protein kinases such as the extracellular signal-related protein kinase (ERK) pathway. This study explored the kinetics, calcium-dependency and intracellular signals following application of capsaicin and l…
Altered hip control during a standing knee-lift test is associated with increased risk of knee injuries
2020
Few prospective studies have investigated hip and pelvic control as a risk factor for lower extremity (LE) injuries. The purpose of this study was to investigate whether deficits in hip and lumbopelvic control during standing knee lift test are associated with increased risk of acute knee and LE injuries in youth team sports. At baseline, 258 basketball and floorball players (aged 12‒21 y.) participated in a standing knee lift test using 3‐dimensional motion analysis. Two trials per leg were recorded from each participant. Peak sagittal plane pelvic tilt and frontal plane pelvic drop/hike were measured. Both continuous and categorical variables were analysed. New non‐contact LE injuries, an…
Gait Variability Using Waist- and Ankle-Worn Inertial Measurement Units in Healthy Older Adults
2020
Gait variability observed in step duration is predictive of impending adverse health outcomes among apparently healthy older adults and could potentially be evaluated using wearable sensors (inertial measurement units, IMU). The purpose of the present study was to establish the reliability and concurrent validity of gait variability and complexity evaluated with a waist and an ankle-worn IMU. Seventeen women (age 74.8 (SD 44) years) and 10 men (73.7 (4.1) years) attended two laboratory measurement sessions a week apart. Their stride duration variability was concurrently evaluated based on a continuous 3 min walk using a force plate and a waist- and an ankle-worn IMU. Their gait complexity (…
Performance in dynamic movement tasks and occurrence of low back pain in youth floorball and basketball players
2020
Abstract Background Prospective studies investigating risk factors for low back pain (LBP) in youth athletes are limited. The aim of this prospective study was to investigate the association between hip-pelvic kinematics and vertical ground reaction force (vGRF) during landing tasks and LBP in youth floorball and basketball players. Methods Three-hundred-and-eighty-three Finnish youth female and male floorball and basketball players (mean age 15.7 ± 1.8) participated and were followed up on for 3 years. At the beginning of every study year the players were tested with a single-leg vertical drop jump (SLVDJ) and a vertical drop jump (VDJ). Hip-pelvic kinematics, measured as femur-pelvic angl…
Effects of Joint Kinetics on Energy Cost during Repeated Vertical Jumping
2019
The present study was designed to investigate the effects of lower limb joint kinetics on energy cost during jumping.Eight male middle and long-distance runners volunteered for the study. The subjects were asked to repeat vertical jumps at a frequency of 2 Hz for 3 min on a force platform in three different surface inclination conditions: Incline (+8°), Level (0°), and Decline (-8°). Sagittal plane kinematics were obtained using a high-speed video camera. Simultaneously, ground reaction forces and EMG of the lower limb muscles were recorded. Energy cost was calculated using steady-state oxygen uptake, respiratory ratio, and vertical distance of the body.In all conditions, energy cost correl…