Search results for "mek"
showing 10 items of 844 documents
Technical determinants of biathlon standing shooting performance before and after race simulation
2018
The aim of this study was to identify performance- determining factors in biathlon standing shooting in rest and after intense exercise. Eight Finnish national- and nine junior- team biathletes participated in the study. Participants fired 40 resting shots (REST) and 2 × 5 competition simulation shots (LOAD) after 5 minutes of roller skiing at 95% of peak heart rate. Hit percentage, aiming point trajectory and postural balance were measured from each shot. Cleanness of triggering (ATV, movement of the aiming point 0- 0.2 second before the shot) and vertical stability of hold (DevY) were the most important components affecting shooting performance both in REST (DevY, R = −0.61, P < .01; ATV,…
Axial loading and posture cues in contraction of transversus abdominis and multifidus with exercise
2020
AbstractAstronauts are at increased risk of spine injury. With a view to developing training approaches for the muscles of the spine in microgravity, this study examined the effects of axial loading and postural cues on the contraction of transversus abdominis and lumbar multifidus in supine lying using a novel exercise device (GravityFit). Thirty (18 males and 12 females) endurance-trained runners without a history of spinal pain aged 33–55 years were recruited. Magnetic resonance imaging (MRI) was performed under one rest and five exercise conditions, which involved variations in axial loading and postural cues. Whole volume of the abdominal and lumbar paraspinal muscles was imaged and tr…
Performance‐determining factors in biathlon prone shooting without physical stress
2021
This study investigated the most important factors determining biathlon prone shooting performance. 10 female and 16 male biathletes (age 19.9 ± 2.9 years) from the national teams of Finland and Vuokatti-Ruka Sports Academy performed 65 biathlon prone shooting shots without physical stress under laboratory conditions. Shooting performance and multiple aiming point trajectory variables were measured together with an analysis of triggering force. Based on the aiming point trajectory data principal component analysis, we identified four technical components in biathlon prone shooting: stability of hold, aiming accuracy, cleanness of triggering and timing of triggering. Multiple regression anal…
Foot Strike Pattern, Step Rate, and Trunk Posture Combined Gait Modifications to Reduce Impact Loading during Running
2019
Elevated impact loading can be detrimental to runners as it has been linked to the increased risk of tibial stress fracture and plantar fasciitis. The objective of this study was to investigate the combined effects of foot strike pattern, step rate, and anterior trunk lean gait modifications on impact loading in runners. Nineteen healthy runners performed 12 separate gait modification trials involving: three foot strike patterns (rearfoot, midfoot, and forefoot strike), two step rates (natural and 10% increased), and two anterior trunk lean postures (natural and 10-degree increased flexion). Overall, forefoot strike combined with increased step rate led to the lowest impact loading rates, a…
Greater maintenance of bone mineral content in male than female athletes and in sprinting and jumping than endurance athletes: a longitudinal study o…
2020
Abstract Summary We investigated longitudinal changes in tibia bone strength in master power (jumping and sprinting) and endurance (distance) athletes of both sexes. Bone mass but not cross-sectional moment of inertia was better maintained in power than endurance athletes over time, particularly in men and independent of changes in performance. Objective Assessment of effects of sex and athletic discipline (lower limb power events, e.g. sprint running and jumping versus endurance running events) on longitudinal changes in bone strength in masters athletes. Methods We examined tibia and fibula bone properties at distal (4% distal-proximal tibia length) and proximal (66% length) sites using p…
Feasibility and reproducibility of electroencephalography-based corticokinematic coherence
2020
Corticokinematic coherence (CKC) is the phase coupling between limb kinematics and cortical neurophysiological signals, reflecting cortical processing of proprioceptive afference, and it is reproducible when estimated with magnetoencephalography (MEG). However, feasibility and reproducibility of CKC based on electroencephalography (EEG) is still unclear and is the primary object of the present report. Thirteen healthy right-handed volunteers (seven females, 21.7 ± 4.3 yr) participated in two combined MEG/EEG sessions 12.6 ± 1.3 mo apart. Participants' dominant and nondominant index finger was continuously moved at 3 Hz for 4 min separately using a pneumatic-movement actuator. Coherence was …
Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF -mutant melanoma (COLUMBUS): a multicentre, open-label, randomis…
2017
Summary Background Combined BRAF-MEK inhibitor therapy is the standard of care for BRAF V600 -mutant advanced melanoma. We investigated encorafenib, a BRAF inhibitor with unique target-binding properties, alone or in combination with the MEK inhibitor binimetinib, versus vemurafenib in patients with advanced BRAF V600 -mutant melanoma. Methods COLUMBUS was conducted as a two-part, randomised, open-label phase 3 study at 162 hospitals in 28 countries. Eligible patients were aged 18 years or older and had histologically confirmed locally advanced (American Joint Committee on Cancer [AJCC] stage IIIB, IIIC, or IV), unresectable or metastatic cutaneous melanoma, or unknown primary melanoma; a B…
Sprint mechanics evaluation using inertial sensor-based technology: A laboratory validation study.
2018
Advances in micro-electromechanical systems have turned magnetic inertial measurement units (MIMUs) into a suitable tool for vertical jumping biomechanical evaluation. Thus, this study aimed to determine whether appropriate reliability and agreement reports could also be obtained when analyzing 20-m sprint mechanics. Four bouts of 20-m sprints were evaluated to determine whether the data provided by a MIMU placed at the lumbar spine could reliably assess sprint mechanics and to examine the validity of the MIMU sensor compared to force plate recordings. Maximal power (P0), force (F0), and velocity (V0), as well as other mechanical determinants of sprint performance associated with the force-…
Muscle-tendon architecture in Kenyans and Japanese : Potential role of genetic endowment in the success of elite Kenyan endurance runners
2022
Aim The specificity of muscle-tendon and foot architecture of elite Kenyan middle- and long-distance runners has been found to contribute to their superior running performance. To investigate the respective influence of genetic endowment and training on these characteristics, we compared leg and foot segmental lengths as well as muscle-tendon architecture of Kenyans and Japanese males (i) from infancy to adulthood and (ii) non-athletes versus elite runners. Methods The 676 participants were divided according to their nationality (Kenyans and Japanese), age (nine different age groups for non-athletes) and performance level in middle- and long-distance races (non-athlete, non-elite and elite …
Work-Related Biomechanical Exposure and Job Strain as Separate and Joint Predictors of Musculoskeletal Diseases: A 28-Year Prospective Follow-up Study
2017
We investigated how work-related biomechanical exposure and job strain in midlife separately and jointly predicted back and degenerative musculoskeletal diseases (MSDs). A total of 6,257 employees participated in the Finnish Longitudinal Study on Aging Municipal Employees (FLAME) in 1981 and were followed up for 28 years. Risk ratios and the relative excessive risk due to interaction and 95% confidence intervals were modeled for separate and joint prediction estimates, respectively. After adjustment for confounders, job strain predicted degenerative MSDs among women after 4 and 11 years of follow-up. After 11 years, both exposures predicted both types of MSDs among men. Joint exposure predi…