Search results for "mek"
showing 10 items of 844 documents
Distinct muscle-tendon interaction during running at different speeds and in different loading conditions
2019
The interaction between the Achilles tendon and the triceps surae muscles seems to be modulated differently with various task configurations. Here we tested the hypothesis that the increased forces and ankle joint work during running under contrasting conditions (altered speed or load) would be met by different, time-dependent adjustments at the muscle-tendon level. Ultrasonography, electromyography, kinematics, and ground reaction force measurements were used to examine Achilles tendon, gastrocnemius, and soleus muscle mechanics in 16 runners in four different running conditions, consisting of a combination of two different speeds (preferred and +20% of preferred speed) and two loading con…
Kognitīvās saskaņotības meklēšana attieksmes formulēšanā
2018
Pētījuma mērķis bija noskaidrot, vai kognitīvā saskaņotība tiek meklēta, cilvēkam izteikti nosliecoties vienas attieksmes virzienā, ja viņš ir saņēmis pozitīvus un negatīvus aspektus saturošu informāciju par konkrētu tēmu un pirms minētās informācijas saņemšanas ir ticis informēts, ka viņam būs jāpieņem lēmums par savu galējo attieksmi attiecībā uz tēmu. Pētījumam ir starpgrupu un iekšgrupu eksperimentālais dizains. Eksperimentalā grupa, kur respondenti tika informēti par to, ka būs jānoformulē attieksme, tika salīdzināta ar trīs kontroles grupām, kur katrā arvien tika samazināts izmantoto manipulāciju skaits. Kopā pētījumā piedalījās 122 dalībnieki. Dati tika analizēti, izmantojot dispersi…
Apsūdzības saturs
2021
Maģistra darbā tiek pētīts apsūdzības saturs, apskatot apsūdzības institūtu Latvijā jēdziena plašākā nozīmē, veicot tā normu analizēšanu, galvenos tiesību īstenošanas aspektus un problemātiku. Darba mērķis ir apzināt pašreizējo situāciju praksē, saskatīt problēmas un piedāvāt iespējamos risinājumus pašreizējā regulējuma uzlabošanai problēmjautājumu kontekstā. Autore, izvērtējot iegūto informāciju, maģistra darbā piedāvā iespējamos grozījumus Kriminālprocesa likumā, piedāvā paplašināt Kriminālprocesa likuma 405. panta pirmo daļu ar apsūdzības definējumu, izsakot attiecīgajā redakcijā, tādejādi veidojot vienotu izpratni par apsūdzības definējumu. Tāpat darbā tiek piedāvāti grozījumi un ieteik…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Giant enhancement to spin battery effect in superconductor/ferromagnetic insulator systems
2021
We develop a theory of the spin battery effect in superconductor/ferromagnetic insulator (SC/FI) systems taking into account the magnetic proximity effect. We demonstrate that the spin-energy mixing enabled by the superconductivity leads to the enhancement of spin accumulation by several orders of magnitude relative to the normal state. This finding can explain the recently observed giant inverse spin Hall effect generated by thermal magnons in the SC/FI system. We suggest a nonlocal electrical detection scheme which can directly probe the spin accumulation driven by the magnetization dynamics. We predict a giant Seebeck effect converting the magnon temperature bias into the nonlocal voltag…
International Conference for Mathematical Modeling and Optimization in Mechanics : book of abstracts : University of Jyväskylä, March 6-7, 2014
2014
This book of abstracts presents materials of the International Conference for Mathematical Modeling and Optimization in Mechanics (MMOM 2014) 6-7 March 2014, Jyväskylä, Finland. This event is dedicated to Professor Nikolay Banichuk in occasion of his 70th anniversary. It is aimed to present the latest results of leading scientists in mathematical modeling, numerical analysis, and optimization theory and to discuss the state of the art and open problems in the field. The book is divided in five sections: 1. Mathematical Modelling of Complex Systems 2. Stability Analysis and Vibration 3. Optimization 4. Methods of Numerical Analysis 5. Shape Optimization
Best Practices in Constant pH MD Simulations: Accuracy and Sampling
2022
Various approaches have been proposed to include the effect of pH in molecular dynamics (MD) simulations. Among these, the λ-dynamics approach proposed by Brooks and co-workers [Kong, X.; Brooks III, C. L. J. Chem. Phys.1996, 105, 2414−2423] can be performed with little computational overhead and hfor each typeence be used to routinely perform MD simulations at microsecond time scales, as shown in the accompanying paper [Aho, N. et al. J. Chem. Theory Comput.2022, DOI: 10.1021/acs.jctc.2c00516]. At such time scales, however, the accuracy of the molecular mechanics force field and the parametrization becomes critical. Here, we address these issues and provide the community with guidelines on…
Detailed modeling of the kraft pulping chemistry : carbohydrate reactions
2020
The article introduces a detailed model for carbohydrate chemistry in kraft pulping. This article is continuation to the modeling work carried out for hot water extraction and chemical pulp bleaching. The model includes galactoglucomannan, xylan, and cellulose acid–base equilibria, in addition to peeling, stopping, and alkaline hydrolysis reactions of the same carbohydrates, as well as hexenuronic acid formation and degradation reactions. The Arrhenius parameters were applied from the literature or regressed against experimental data in the present study. The model is very successful in predicting the experimental data of carbohydrate reactions during kraft pulping. Many features of the pul…
On stochastic modelling and reliability of systems with moving cracked material
2015
In many industrial processes, such as printing paper, a material travels through a series of rollers unsupported and under longitudinal tension. The value of the tension has an important role in the system behaviour, such as fracture and me- chanical stability. This thesis develops stochastic models for a system in which an elastic, isotropic cracked material travels through a series of spans and studies the probabilities of fracture and instability of the material. The models focus on describing tension variations and initial cracks in the material. Time-dependent tension fluctuations are modelled by the stationary Ornstein-Uhlenbeck process, and the occurrence and lengths of the cracks are…