Search results for "mem"
showing 10 items of 7971 documents
YIZKEREM. May Our Lord Remember Them (from Hebrew), for acappella mixed choir
2021
La obra YIZKEREM (del hebreo: Que nuestro Señor los recuerde) es un monumento al Holocausto de la nación judía. Dado que la compositora, Bracha Bdil, pertenece a la comunidad ortodoxa de Europa del Este, muchas de sus obras se basan en la tradición musical de los modos judíos de Europa del Este y los textos de estas fuentes. La fusión de la técnica compositiva contemporánea con los elementos de la antigua tradición judía conduce a la compositora a un lenguaje compositivo muy personal.
Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin s…
1994
Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol…
Rho GTPases are over-expressed in human tumors.
1999
Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…
Targeting the mevalonate pathway for improved anticancer therapy.
2009
The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O
2001
The pore-forming toxin streptolysin O (SLO) can be used to reversibly permeabilize adherent and nonadherent cells, allowing delivery of molecules with up to 100 kDa mass to the cytosol. Using FITC-labeled albumin, 10 5 –10 6 molecules were estimated to be entrapped per cell. Repair of toxin lesions depended on Ca 2+ -calmodulin and on intact microtubules, but was not sensitive to actin disruption or to inhibition of protein synthesis. Resealed cells were viable for days and retained the capacity to endocytose and to proliferate. The active domains of large clostridial toxins were introduced into three different cell lines. The domains were derived from Clostridium difficile B-toxin and Clo…
1988 12. 30 de diciembre de 1988. Dimite Ricard Pérez Casado, alcalde de Valencia
2014
1988 12. 30 de diciembre de 1988. Dimite Ricard Pérez Casado, alcalde de Valencia. Tras más de nueve años como alcalde de Valencia (1979-1988) la prensa local recogía en portada la dimisión de Ricard Pérez Casado como alcalde de Valencia, al que acompañaba su número dos, Fernando Puente Roig. Tres años después, el IV congreso del PSPV -Alicante 1985- le pasaba factura, por haber sido elegido secretario general de la ciudad de Valencia, frente a la lista de Joan Lerma. Con su dimisión desaparecía otro de los que se habían identificado con la renovación del partido. Pérez Casado es uno de los pocos políticos valencianos que ha publicado sus memorias políticas en primera persona: "Viaje de ida…
La memoria dell'acqua. Antichi sistemi di approvvigionamento e distribuzione idrica a Palermo: torri, urne e castelletti.Water memory. Old systems of…
2009
Abstract The water flowing from the tap of our houses accounts for the final step of a long and complicated route beaten by time and man; the latter has always committed himself to making the best of such resource, by testing over time different technological solutions according to the environmental, geographical and cultural conditions of the various territories. Man has dug wells and reservoirs in order to collect, assemble and retain water and has carried out and implemented all the works that were necessary to make water supply more useful and efficient: waterworks, fountains, drinking troughs and water systems bringing the vital element from door to door and which, over the centuries, …
M. Kilani, Une expérience de la révolution tunisienne. Réflexions recuiellis par Gabriella D’Agostino
2011
Rilkean Memories and the Self of a Robot
2019
This paper discusses the concept of Rilkean memories, recently introduced by Mark Rowlands, to analyze the complex intermix of hardware and software related to the self of a robot. The Rilkean memory of an event is related to the trace of that episode left in the body of the individual. It transforms the act of remembering into behavioral and bodily dispositions, thus generating the peculiar behavioral style of the individual, which is at the basis of her autobiographical self. In the case of long-life operating robots, a similar process occurs: the software of the robot has to cope with the changes that happened in the body of the robot because of damaging events in its operational life. T…
20.gadsimta 20.,30.gadu Rīga Andreja Johansona, Marisa Vētras un Paulas Jēgeres- Freimanes memuāros
2017
Maģistra darba „20.gadsimta 20.-30.gadu Rīga Andreja Johansona, Marisa Vētras un Paulas Jēgeres-Freimanes memuāros” mērķis ir izpētes rezultātā raksturot 20.gadsimta 20-.-30.gadu Rīgas kultūrvēsturisko un topogrāfisko vidi trimdas autoru: Andreja Johansona, Marisa Vētras un Paulas Jēgeres-Freimanes memuāros. Rīgas nozīmība ir veidojusies vairāku gadsimtu garumā, taču Latvijas brīvvalsts laikā tā piedzīvoja kultūras un mākslas uzplaukumu, kas radīja pamatu tādiem apzīmējumiem kā “zelta laikmets” un “zaudētā paradīze”. Atsevišķu trimdas autoru memuāri ir uzskatāmi par īpaši spilgtu atzīšanos mīlestībā savai pilsētai Rīgai, jo tam līdzās nāk autoru emocionāli psiholoģiskais aspekts un arī apli…