Search results for "meningitis"

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis

1976

Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL). CTL generated in vitro against 2,4,6-trinitrophenyl (TNP)-conjugated syngeneic stimulator cells were specifically cytotoxic for TNP-conjugated H-2K (D) region identical targets. Both LCM and vaccinia-induced CTL, however, were found to be strongly cytotoxic towards TNP-conjugated, H-2K(D) region-identical target cells. In contrast, Sendai virus-induced CTL did not lyse TNP-conjugated, syngeneic target cells. Inhibition experiments using cold targets suggested that shared antigenic…

Neurological manifestations of the West Nile virus infection in some cases found in the clinic of infectious diseases in Sibiu, Romania

2014

Background The neurological manifestations in the West Nile virus infections are present in less than 1% of the diagnosed cases, neurological manifestations which may take many different forms, from encephalitis, meningitis, GuillainBarre syndrome, optic neuritis to polio-like manifestations. We aimed to evaluate the clinical and paraclinical aspects of the cases presenting neurological infections caused by the West Nile virus diagnosed and treated in our clinic.

Suitability of OMI aerosol index to reflect mineral dust surface conditions: preliminary application for studying the link with meningitis epidemics …

2013

12 pages; International audience; The aimof this study is to analyze the suitability of remotely-sensed aerosol retrievals to progress in the understanding of the influence of desert dust on health, and particularly on meningitis epidemics. In the Sahel, meningitis epidemics are a serious public health issue. Social factors are of prime importance in the dynamics of the epidemics, however climate and environmental factors are also suspected to play an important role. This study focuses on three Sahelian countries (Burkina Faso,Mali and Niger) which are among the most concerned in the "meningitis belt" and affected by strong dust events every year. It investigates the capability of the aeros…

Meningitis caused by Enterococcus gallinarum after lumbar drainage of cerebrospinal fluid.

2005

We report a rare case of meningitis caused by Enterococcus gallinarum, a bacterium characterized by its ability to express low-level resistance to vancomycin. As in the three other previously reported cases, this one occurred in a patient with a cerebrospinal fluid drainage catheter and properly responded to antimicrobial therapy and removal of the drain.

Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcγR

2013

CD8(+) T cells have an essential role in controlling lymphocytic choriomeningitis virus (LCMV) infection in mice. Here, we examined the contribution of humoral immunity, including nonneutralizing antibodies (Abs), in this infection induced by low virus inoculation doses. Mice with impaired humoral immunity readily terminated infection with the slowly replicating LCMV strain Armstrong but showed delayed virus elimination after inoculation with the faster replicating LCMV strain WE and failed to clear the rapidly replicating LCMV strain Docile, which is in contrast to the results obtained with wild-type mice. Thus, the requirement for adaptive humoral immunity to control the infection was dep…

Nuevas aplicaciones del sistema MALDI-TOF MS en la Microbiología Clínica

2022

La espectrometría de masas es una técnica de determinación estructural que permite estudiar la distribución de las moléculas de una sustancia en función de su masa. Un espectro de masas es una relación de las especies iónicas presentes en una muestra, expresadas en función de su masa/carga (m/z) y la abundancia relativa (intensidad) de cada una en la muestra. La espectrometría de masas fue utilizada históricamente como una técnica analítica de la química clínica, pero no fue hasta hace tres décadas con la aparición de las técnicas de “ionización suave” cuando se consiguió analizar biomoléculas de gran tamaño utilizando un láser como fuente de ionización y una matriz orgánica para facilitar …

How the knowledge of interactions between meningococcus and the human immune system has been used to prepare effective Neisseria meningitidis vaccines

2015

In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity ofNeisseria meningitidisat a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). Here, we review the molecular biology of the infectious agent and, in particular, its interactions with the immune system, focusing on both the innate and the adaptive responses. Meningococci exploit different mechanisms and complex machineries in order to subvert the immune system and to avoid being killed. Capsular polysaccharide and lipooligosaccharide glycan composition, in…

Meningitis and subdural empyema as complication of pterygomandibular space abscess upon tooth extraction

2016

Complication of dental infections might be various and heterogeneous. The most common complications are represented by maxilar celulitis, canine space celulitis, infratemporal space celulitis, temporal celulitis and bacteremia. Among rarest complications we found: sepsis, bacterial endocarditis, mediastinitis, intracranial complications, osteomyelitis, etc. Although dental infections are often considered trivial entities, sometimes they can reach an impressive gravity. In this regard, the present study describes a case of dental infection complicated by meningitis, subdural empiema and cerebral vasculitis. Furthermore, we observed other neurological complications, like thalamic ischemic inf…

2015

OBJECTIVES: To update the epidemiology of S. aureus bloodstream infection (SAB) in a high-income country and its link with infective endocarditis (IE).METHODS: All consecutive adult patients with incident SAB (n = 2008) were prospectively enrolled between 2009 and 2011 in 8 university hospitals in France. RESULTS: SAB was nosocomial in 54%, non-nosocomial healthcare related in 18% and community-acquired in 26%. Methicillin resistance was present in 19% of isolates. SAB Incidence of nosocomial SAB was 0.159/1000 patients-days of hospitalization (95% confidence interval [CI] 0.111-0.219). A deep focus of infection was detected in 37%, the two most frequent were IE (11%) and pneumonia (8%). Th…

Epidemiology of pneumococcal disease in children in Germany

2001

UNLABELLED Recently published and as yet unpublished data allow a reasonable estimate of the annual burden of pneumococcal disease in Germany. At least 277,000 episodes of otitis media and at least 2,000 episodes of sinusitis occur in children under the age of 5 y. Pneumococcal meningitis was found in 200 children under the age of 16 y; the estimate for all age groups ranges from 450 to 1100 cases. Of approximately 150,000 cases of ambulatory pneumococcal pneumonia, at least 63,000-105,000 patients are hospitalized each year. CONCLUSION Further studies of pneumococcal epidemiology in Germany are needed, and continued surveillance will be necessary for a better understanding of the overall b…