Search results for "metaanálisis"

showing 3 items of 3 documents

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

2020

Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA an…

:Chemicals and Drugs::Pharmaceutical Preparations::Placebos [Medical Subject Headings]Physiologyα -lipoic acid ; thioctic acid ; dietary supplement ; safety ; meta-analysisClinical BiochemistryDisease030204 cardiovascular system & hematologyBiochemistrymeta-analysi:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings]Dietary supplementchemistry.chemical_compound0302 clinical medicinethioctic aciddietary supplement meta-analysis safety thioctic acid α-lipoic acid:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]α-lipoic acidLipoic acidSafety profile:Publication Type::Study Characteristics::Meta-Analysis [Medical Subject Headings]Suplementos dietéticosMeta-analysis:Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings]SafetysafetyAlpha-lipoic acidmedicine.medical_specialtyMEDLINEÁcido tióctico030209 endocrinology & metabolismPlacebo:Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes::Thioctic Acid [Medical Subject Headings]Article:Health Care::Environment and Public Health::Public Health::Accidents::Accident Prevention::Safety [Medical Subject Headings]03 medical and health sciencesα‐lipoic acidThioctic acidInternal medicineDiabetes mellitusmedicineMetaanálisisAdverse effectSeguridad:Diseases::Cardiovascular Diseases [Medical Subject Headings]Molecular Biology:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Volatile [Medical Subject Headings]business.industryRevisión sistemáticalcsh:RM1-950Cell Biologymedicine.disease:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Food Habits::Smoking [Medical Subject Headings]meta-analysisMeta-analysislcsh:Therapeutics. Pharmacologychemistry:Diseases::Nervous System Diseases [Medical Subject Headings]dietary supplementMeta‐analysisbusinessAntioxidants
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Volumetric changes in alveolar ridge preservation with a compromised buccal wall: a systematic review and meta-analysis.

2020

Background Many studies have addressed socket preservation, though fewer publications considering buccal wall loss can be found, since the literature typically considers sockets with four walls. A systematic review was made on the influence of type II buccal bone defects, according to Elian’s Classification, in socket grafting materials upon volumetric changes in width and height. Material and Methods An electronic and manual literature search was conducted in accordance to PRISMA statement. The search strategy was restricted to randomized controlled trials (RCTs) and controlled clinical trials (CCTs) describing post-extraction sockets with loss of buccal wall in which alveolar ridge preser…

Cresta alveolarBone lossParet òssia bucalTest groupAlveolar Bone LossBuccal wall616.3ReviewVolumetric changeslaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawAlveolar ridgeAlveolar ProcessMedicinePeriodontologyCanvis volumètricsTooth SocketMetaanálisisGeneral DentistryOrthodonticsSocket preservationCambios volumétricosWound Healingbusiness.industryAlveolar process030206 dentistryBuccal administrationAlveolar Ridge AugmentationAlveolar Ridge AugmentationDefecte de la paret bucal:CIENCIAS MÉDICAS [UNESCO]Defecto de la pared bucalDefects of the oral wallMeta-analysismedicine.anatomical_structureOtorhinolaryngologyMeta-analysisUNESCO::CIENCIAS MÉDICASTooth ExtractionPèrdua òssiaSurgeryPérdida óseaAlveolar ridgebusinessPared ósea bucalMetaanàlisiMedicina oral, patologia oral y cirugia bucal
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Métodos de análisis de enriquecimiento funcional en estudios genómicos

2016

Los métodos computacionales tienen un papel fundamental en la resolución de problemas clínicos y biológicos. La generación de grandes cantidades de datos procedentes de tecnologías de alto rendimiento y el incremento de información accesible en bases de datos biológicos, han potenciado la demanda de nuevas metodologías capaces de relacionar ambos elementos. Para hacer frente a esta necesidad de la comunidad de investigación biomédica, en este trabajo presentamos una serie de contribuciones en el campo de la Genómica Funcional que ayudarán a los investigadores en la interpretación funcional de sus análisis de datos genómicos. Durante la primera parte de esta tesis, se describe el desarrollo …

metaanálisis:CIENCIAS TECNOLÓGICAS [UNESCO]microARNUNESCO::CIENCIAS TECNOLÓGICAS:CIENCIAS MÉDICAS [UNESCO]:CIENCIAS DE LA VIDA [UNESCO]biología molecular:MATEMÁTICAS [UNESCO]bioestadísticabioinformáticagenómica funcionalUNESCO::CIENCIAS MÉDICASUNESCO::CIENCIAS DE LA VIDAbiología de sistemasanálisis de datosUNESCO::MATEMÁTICAS
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