Search results for "metabolomika"

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The role of pumpkin pulp extract carotenoids against mycotoxin damage in the blood brain barrier

2021

Some mycotoxins such as beauvericin (BEA), ochratoxin A (OTA), and zearalenone (ZEA) can cross the blood brain barrier, which is why we tested the anti-inflammatory action of a pumpkin carotenoid extract (from the pulp) against these mycotoxins and their combinations (OTA+ZEA and OTA+ZEA+BEA) on a blood brain barrier model with co-cultured ECV304 and C6 cells using an untargeted metabolomic approach. The cells were added with mycotoxins at a concentration of 100 nmol/L per mycotoxin and pumpkin carotenoid extract at 500 nmol/L. For control we used only vehicle solvent (cell control) or vehicle solvent with pumpkin extract (extract control). After two hours of exposure, samples were analysed…

Ochratoxin AMetaboliteProstaglandinToxicologychemistry.chemical_compoundCucurbitametabolomikaFood scienceMycotoxinZearalenoneCarotenoidchemistry.chemical_classificationzearalenonPlant ExtractsECV304fungibeauvericinzearalenonePublic Health Environmental and Occupational Healthfood and beveragesMycotoxinsCarotenoidsOchratoxinsmetabolomicsBeauvericinchemistryBlood-Brain Barrierbovericinokratoksin AArachidonic acidOriginal Articleochratoxin AArhiv za higijenu rada i toksikologiju

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