Search results for "method"
showing 10 items of 13253 documents
Designing a graphics processing unit accelerated petaflop capable lattice Boltzmann solver: Read aligned data layouts and asynchronous communication
2016
The lattice Boltzmann method is a well-established numerical approach for complex fluid flow simulations. Recently, general-purpose graphics processing units (GPUs) have become available as high-performance computing resources at large scale. We report on designing and implementing a lattice Boltzmann solver for multi-GPU systems that achieves 1.79 PFLOPS performance on 16,384 GPUs. To achieve this performance, we introduce a GPU compatible version of the so-called bundle data layout and eliminate the halo sites in order to improve data access alignment. Furthermore, we make use of the possibility to overlap data transfer between the host central processing unit and the device GPU with com…
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…
2021
Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …
Regularity for nonlinear stochastic games
2015
We establish regularity for functions satisfying a dynamic programming equation, which may arise for example from stochastic games or discretization schemes. Our results can also be utilized in obtaining regularity and existence results for the corresponding partial differential equations. peerReviewed
The ALICE experiment at the CERN LHC
2008
Journal of Instrumentation 3(08), S08002 (2008). doi:10.1088/1748-0221/3/08/S08002
Visual occlusion as tool to assess attentional demand and spare capacity
2021
Vai strukturālās reformas spēs veicināt Latvijas ekonomisko izaugsmi: BMA un GMM novērtējumu liecības
2017
Pētījuma ietvaros tiek pielietota Beijesa modeļu svēršana (BMA) un vispārīgā momentu metode (GMM) Globālās Konkurētspējas apakšindeksu (GCI) datiem, lai identificētu strukturālo reformu jomas, kas var nozīmīgi paātrināt Latvijas ekonomisko izaugsmi. Novērtējumu rezultāti, kuros ņemta vērā gan modeļu nenoteiktība, gan endogenitāte liecina, ka ekonomisko izaugsmi var veicināt ar augstākām investīcijām, zemāku administratīvo slogu, stabilāku makroekonomisko vidi, paaugstinātu ārvalsts tiešo investīciju kvalitāti, kā arī ar attīstītākiem uzņēmējdarbības klasteriem. Ja šajās jomās Latvijas sniegums pēdējo 10 gadu laikā būtu trīs labāko Eiropas Savienības dalībvalstu līmenī, tad ienākumu līmenis …
Visual methods in Applied Language Studies
2018
This introductory article serves two purposes. Firstly, it provides the background for the set of 11 articles that appear in the special issue of this journal and summarizes the articles along a number of dimensions. All the articles address aspects of multilingualism as subjectively experienced and they all make use of visual methodologies. Secondly, it subjects the articles to two meta-analyses. The first one compares and contrasts the studies by site: production, image and audiencing. The second one, in contrast, classifies the studies by the research strategy chosen by the researchers: looking, seeing or designing. The article concludes by pointing to future directions in research on mu…
Researching Children’s Multiple Family Relations: Social Network Maps and Life-Lines as Methods
2015
Visual methods are reported to have certain advantages when conducting interviews on sensitive topics, such as intimate spaces, home-related ethical issues, and vulnerable families. In this article, we concentrate on two visual methods: social network maps and life-lines. In our research project on children’s well-being and emotional security in multiple family relations, we collected data by interviewing children and asking them to complete social network maps and life-lines. We discuss the suitability of these two visual methods for describing children’s close relationships with their family members and significant others. Combining these two methods during an interview process with child…
A Moldvai Csángómagyar Oktatási Program kutatása és támogatása vizuális módszerekkel
2018
A Moldvai Csángómagyar Oktatási Program kutatása és támogatása egy több éves (2016– 2021), a Finn Akadémia által támogatott projekt (projektszáma, 299133), amelynek anyaga 30 moldvai településen folyatatott, 2017–2019 között végzett terepmunkából áll. A terepmunka szakaszai során számos vizuális és digitális módszertani eljárás is bevezetésre kerül, s az ezek segítségével készített anyagokból nagy terjedelmű, multimodális adatbázis jön létre. Cikkemben néhány, eddig sikeresnek bizonyult módszert mutatok be, különös tekintettel arra, hogy ezek segítségével hogyan válaszolhatók meg a kutatási kérdéseim. A kötet témájához igazodva kutatásomnak a nyelvitájkép-kutatások között elfoglalt helyét i…