Search results for "methodologie"
showing 10 items of 2141 documents
DNA Block Copolymer Micelles – A Combinatorial Tool for Cancer Nanotechnology
2008
Selective drug targeting of a specific organ or tissue is a challenging task. This holds especially true for chemotherapeutic cancer treatment because most of the available anticancer agents cannot distinguish between cancerous and healthy cells, leading to systemic toxicity and undesirable side effects. One effective approach to address this problem is the application of polymeric nanoparticles equipped with targeting units for tumor-specific delivery. For instance dendrimers, highly branched macromolecules, can be equipped with targeting units as well as with anticancer drugs because of their large number of surface functionalities. Amphiphilic block copolymers, which self-assemble in dil…
Fast Axial-Scanning Widefield Microscopy With Constant Magnification and Resolution
2015
In this paper, we propose the use of electrically-addressable lens devices for performing fast non-mechanical axial scanning when imaging three-dimensional samples. This non-mechanical method can be implemented in any commercial microscope. The approach is based on the insertion of the tunable lens at the aperture stop of the microscope objective. By tuning the voltage, a stack of depth images of 3D specimens can be captured in real time and with constant magnification and resolution. The main advantage of our technique is the possibility of performing fast axial scanning free of mechanical vibrations.
FERROELECTRIC LIQUID CRYSTAL GLASSES FOR AMBLYOPIA RESEARCH
2008
ABSTRACT Ferroelectric Liquid Crystal (FLC) filters offer the speed of electronic light shutters and the vibration free operation. These characteristics make them ideal for applications requiring short exposure times and minimal blur, offering switching times of 0.0002 of a second. FLC filters can be used as the optical shutters for machine vision purposes, also in vision research. On the basis of FLC filters we have developed ferroelectric glasses, allowing temporal separation of optical information for both eyes. In the case of amblyopia (“lazy eye”) the only way to oblige the “lazy” eye to work is to close the other better-seeing eye. We advice an appliance for dynamic visual system trai…
An automated procedure for computing the packing properties of dense and locked sands by image analysis of thin sections
2014
The macroscopic mechanical behaviour of dense sands originates to a great extent from their microstructural characteristics such as the coordination number, the grain contact and the packing density indexes. The study of intergranular contacts and the reckoning of these indexes may be carried out on planar images of the grains either by means of time-consuming visual inspection assisted by CAD or by automatic image analysis. An innovative method for the automatic determination of microstructural characteristics of sands based on image analysis of thin section is proposed. Tests performed on a locked sand show that the proposed method is much more effective, convenient and faster than the us…
Simultaneous dual mode imaging platform in lensless holographic microscopy
2019
We present a novel layout capable of dual mode imaging in real time with different magnifications and resolution capabilities in lensless microscopy based on wavelength multiplexing. Experiments using static and dynamic samples are included.
Towards Multilevel Ant Colony Optimisation for the Euclidean Symmetric Traveling Salesman Problem
2015
Ant Colony Optimization ACO metaheuristic is one of the best known examples of swarm intelligence systems in which researchers study the foraging behavior of bees, ants and other social insects in order to solve combinatorial optimization problems. In this paper, a multilevel Ant Colony Optimization MLV-ACO for solving the traveling salesman problem is proposed, by using a multilevel process operating in a coarse-to-fine strategy. This strategy involves recursive coarsening to create a hierarchy of increasingly smaller and coarser versions of the original problem. The heart of the approach is grouping the variables that are part of the problem into clusters, which is repeated until the size…
A New Crowded Comparison Operator in Constrained Multiobjective Optimization for Capacitors Sizing and Siting in Electrical Distribution Systems
2005
This paper presents a new Crowded Comparison Operator (CCO) for NSGA-II to solve the Multiobjective and constrained problem of optimal capacitors placement in electrical distribution systems.
Performance modeling of epidemic routing
2006
In this paper, we develop a rigorous, unified framework based on ordinary differential equations (ODEs) to study epidemic routing and its variations. These ODEs can be derived as limits of Markovian models under a natural scaling as the number of nodes increases. While an analytical study of Markovian models is quite complex and numerical solution impractical for large networks, the corresponding ODE models yield closed-form expressions for several performance metrics of interest, and a numerical solution complexity that does not increase with the number of nodes. Using this ODE approach, we investigate how resources such as buffer space and the number of copies made for a packet can be tra…
Controller Design Under Fuzzy Pole-Placement Specifications: An Interval Arithmetic Approach
2006
This paper discusses fuzzy specifications for robust controller design, as a way to define different specification levels for different plants in a family and allow the control of performance degradation. Controller synthesis will be understood as mapping a fuzzy plant onto a desired fuzzy set of closed-loop specifications. In this context, a fuzzy plant is considered as a possibility distribution on a given plant space. In particular, pole placement in linear plants with fuzzy parametric uncertainty is discussed, although the basic idea is general and could be applied to other settings. In the case under consideration, the controller coefficients are the solution of a fuzzy linear system o…
Mathematical Morphology Based on Fuzzy Operators
1993
A vision procedure may be considered as the repeated application of image operators until the vision goal is reached. The type of these operators and the spaces on which they are defined and act depends on the specific problem and on what we are searching on the image. Morphological operations, as filtering, edge detection, skeletonizing, and so on, are mainly required at low and medium levels of the vision procedure, where local and global knowledge is used to enhance the image information content, before a final decision about the image is taken.