Search results for "metric"

Sex Differences in the Physiological Network of Healthy Young Subjects

2021

Within human physiology, systemic interactions couple physiological variables to maintain homeostasis. These interactions change according to health status and are modified by factors such as age and sex. For several physiological processes, sex-based distinctions in normal physiology are present and defined in isolation. However, new methodologies are indispensable to analyze system-wide properties and interactions with the objective of exploring differences between sexes. Here we propose a new method to construct complex inferential networks from a normalization using the clinical criteria for health of physiological variables, and the correlations between anthropometric and blood tests b…

Modeling of the Shear Connection Capacity of Hybrid Steel Trussed Composite Beams

2019

Hybrid Steel Trussed Composite Beams represent a technical solution in use in numerous countries since many years. They are able to join the advantages of prefabrication with those of cast in place structures: they are easy to manufacture, fast to realize, monolithic and with no need of formwork. The behavior of these beams has been recently topic of discussion in the scientific community because the knowledge both related to the reinforced concrete structures and that of composite constructions cannot be straightforwardly extended to this typology, which is intermediate between one and another technology. This paper provides a contribution towards a better understanding of the mechanism of…

Nuovi schemi geometrici di intersezioni stradali per l’incremento della capacita e della sicurezza

2011

Testing and implementing a new approach to estimating interregional output multipliers using input-output data for South Korean regions

2020

Flegg's location quotient (FLQ) is a useful tool for estimating intraregional output multipliers. This paper uses it as one component when estimating interregional multipliers. Using statistical information criteria and official data for 16 South Korean regions, it is found that the best approach is to combine the FLQ with a simple trade model. The paper explains how the proposed procedure can be implemented for both multiple and individual regions, and also how a region-specific value for the unknown parameter δ in the FLQ formula can be determined. Finally, an illustrative case study of one of the regions is carried out.

Self-employment duration in urban and rural locations

2009

Previous research has shown that local environment is important for self-employment. Self-employment dynamics varies between areas characterized by different labour market conditions, entrepreneurial tradition and other structural factors. Alternation between different labour market states (self-employment, paid-employment, non-employment) is also likely to increase if employment opportunities remain low in local labour market markets. This paper analyses the factors influencing the duration of self-employment spells in Finland with a large registered-based data set from the period of 1987-2002. It is evident that rates of exit out of self-employment and the length of self-employment spells…

On the scientific work of Victor Isakov

2022

Singular (p, q)-equations with superlinear reaction and concave boundary condition

2020

We consider a parametric nonlinear elliptic problem driven by the sum of a p-Laplacian and of a q-Laplacian (a (Formula presented.) -equation) with a singular and (Formula presented.) -superlinear reaction and a Robin boundary condition with (Formula presented.) -sublinear boundary term (Formula presented.). So, the problem has the combined effects of singular, concave and convex terms. We look for positive solutions and prove a bifurcation-type theorem describing the changes in the set of positive solutions as the parameter varies.

Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors

2019

A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…

On the use of composite indicators for mobile communications network management in smart sustainable cities

2020

Beyond 5G networks will be fundamental towards enabling sustainable mobile communication networks. One of the most challenging scenarios will be met in ultra-dense networks that are deployed in densely populated areas. In this particular case, mobile network operators should benefit from new assessment metrics and data science tools to ensure an effective management of their networks. In fact, incorporating architectures allowing a cognitive network management framework could simplify processes and enhance the network&rsquo

Determining Factors of High Social Connotation Crimes in the Metropolitan Region. A logistic model analysis.

2018

Resumen Las iniciativas enfocadas sólo en acciones de control policial, si bien elevan la percepción de seguridad, no actúan sobre las causas multifactoriales de un problema social dinámico y complejo. Por ende, se deben desarrollar medidas de prevención y de control, las que requieren la participación activa, sinérgica y coordinada de todos los actores involucrados en materia de seguridad pública, para disminuir los factores de riesgo que derivan en el actuar criminal. El objetivo de este trabajo es medir la incidencia de factores espaciales, temporales y elementos de contexto que caracterizan a las comunas de la Región Metropolitana de Chile (2014), en la probabilidad de ocurrencia de del…