Search results for "miR"

Casimir-Lifshitz force out of thermal equilibrium between dielectric gratings

2014

We calculate the Casimir-Lifshitz pressure in a system consisting of two different 1D dielectric lamellar gratings having two different temperatures and immersed in an environment having a third temperature. The calculation of the pressure is based on the knowledge of the scattering operators, deduced using the Fourier Modal Method. The behavior of the pressure is characterized in detail as a function of the three temperatures of the system as well as the geometrical parameters of the two gratings. We show that the interplay between non-equilibrium effects and geometrical periodicity offers a rich scenario for the manipulation of the force. In particular, we find regimes where the force can…

Phytosociology and ecology of deciduous forests in Tajikistan (Middle Asia)

2017

Aims: To present the first syntaxonomical classification for the mesophilous deciduous forests of the PamirAlai Mountains in Tajikistan with some remarks on its environmental gradients. Location: Tajikistan. Methods: Altogether 201 relevés were sampled between 2008‒2013 using the seven-degree cover-abundance scale of Braun-Blanquet. They were classified by the modified TWINSPAN method using the four-step interval scale with cutoff levels of 0%, 2%, 5% and 10% and total inertia as a measure of cluster heterogeneity. Diagnostic species were identified using the phi coefficient as a fidelity measure. Detrendended Correspondence Analysis was used to determine the relation between samples, veget…

New insights regarding Acinetobacter genomic island-related elements

2020

The objective of this study was to mobilize the Acinetobacter genomic island 1-A (AGI1-A) from Enterobacter hormaechei EclCSP2185 (E. cloacae complex) and to search for the distribution and structure of AGI1-related elements in the NCBI database. AGI1-A was transferred to Escherichia coli. Analysis of the attachment (att) sites could locate the possible recombination crossover in the att sequences at position 10-11 (GG) in the last 18 bp of trmE. In silico detection of AGI backbones in the wgs database identified AGI variants in Salmonella enterica (83 strains), Vibrio cholerae (33), E. hormaechei (12), Acinetobacter baumannii (2), most belonging to prevalent clones (ST40, ST69, ST114 and S…

Unijne organy nadzoru nad rynkiem finansowym w procesie stosowania sankcji administracyjnych

2014

Una ciencia admirable: filosofía y admiración en Descartes

2021

RESUMEN Aunque Descartes pretende hablar de cuestiones morales en general, y de las pasiones en particular, como si nadie hubiera escrito antes sobre ellas, lo cierto es que, en el caso de la admiración, es clara su referencia al mundo antiguo. En concreto, en este caso el pensador francés se sitúa críticamente en contra de la postura aristotélica, que entiende la admiración como el inicio de la filosofía. Frente a la propuesta clásica, que convierte dicha emoción en el motor permanente de la investigación de las primeras causas, para Descartes la curiosidad excesiva y el estupor del asombro son rechazables. No obstante, algunos han señalado el carácter ambivalente de las declaraciones cart…

The Affective Geography of Paris in the 19th Century Romanian Novel: Between Admiration and Aversion

2020

Based on “The Emotions of London”, a research project initiated at the Stanford Literary Lab, my article focuses on two relevant issues. First of all, I aim to demonstrate, as the “geography of emotions” experiment has already proved, that distant reading approaches and big data interpretation do not necessarily have to replace traditional methods of analysis. In other words, by using a corpus of 157 texts, I intend to outline the affective image of Paris as presented in the nineteenth century Romanian novel. Secondly, the aspect that makes my article different from “The Emotions of London” is that my purpose does not lie in analysing emotions associated with certain place-names in Paris, b…

Los años de la hegemonía socialista. 1983-1995

2007

"Los años de la hegemonía socialista. 1983-1995" es un capítulo escrito por Benito Sanz en la obra colectiva editada por el diario Levante: "La Gran Historia de la Comunitat Valenciana. La democracia reconquistada. De la Transición a la normalización democrática (1975-2008)", tomo 10, dirigida por Francesc A. Martínez y Antonio Laguna. Valencia 2007. "Los años de la hegemonía socialista. 1983-1995" recoge las tres legislaturas en las que el PSPV-PSOE gobernó de forma hegemónica casi todas las instituciones publicas de España, la Comunidad Valenciana, así como las tres diputaciones provinciales, los tres ayuntamientos de las capitales de las provincias y la gran mayoría de los municipios. Jo…

Erratum: By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy

2019

Basal-like breast cancer is an aggressive tumor subtype with a poor response to conventional therapies. Tumor formation and relapse are sustained by a cell subset of Breast Cancer Stem Cells (BrCSCs). Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 (Plk1) down-regulation. Moreover, miR-100 favors BrCSC differentiation, converting a basal like phenotype into luminal. It induces the expression of a functional estrogen receptor (ER) and renders basal-like BrCSCs responsive to hormonal therapy. The key role played by miR-100 in breast cancer free-survival is confirmed by the analysis of a cohort of patients' tumors, which sho…

Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1

2012

Abstract MicroRNAs (miRNAs) inhibit HIV-1 expression by either modulating host innate immunity or by directly interfering with viral mRNAs. We evaluated the expression of 377 miRNAs in CD4+ T cells from HIV-1 élite long-term nonprogressors (éLTNPs), naive patients, and multiply exposed uninfected (MEU) patients, and we observed that the éLTNP patients clustered with naive patients, whereas all MEU subjects grouped together. The discriminatory power of miRNAs showed that 21 miRNAs significantly differentiated éLTNP from MEU patients and 23 miRNAs distinguished naive from MEU patients, whereas only 1 miRNA (miR-155) discriminated éLTNP from naive patients. We proposed that miRNA expression ma…

Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer.

2014

Cancer is as much an epigenetic disease as a genetic one; however, the interplay between these two processes is unclear. Recently, it has been shown that a large proportion of DNA methylation variability can be explained by allele-specific methylation (ASM), either at classical imprinted loci or those regulated by underlying genetic variants. During a recent screen for imprinted differentially methylated regions, we identified the genomic interval overlapping the non-coding nc886 RNA (previously known as vtRNA2-1) as an atypical ASM that shows variable levels of methylation, predominantly on the maternal allele in many tissues. Here we show that the nc886 interval is the first example of a …