Search results for "miR"

Adipose tissue, angiogenesis and angio-MIR under physiological and pathological conditions.

2019

Angiogenesis is a crucial process for the maintenance of normal tissue physiology and it is involved in tissue remodeling and regeneration. This process is essential for adipose tissue maintenance. The adipose tissue is composed by different cell types including stromal vascular cells as well as adipose stem cells (ASCs). In particular, ASCs are multipotent somatic stem cells that are able to differentiate and secrete several growth factors; they are recently emerging as a new cell reservoir for novel therapies and strategies in many diseases. Several studies suggest that ASCs have peculiar properties and participate in different disease-related processes such as angiogenesis. Furthermore, …

MicroRNAs: Promising New Antiangiogenic Targets in Cancer

2014

[EN] MicroRNAs are one class of small, endogenous, non-coding RNAs that are approximately 22 nucleotides in length; they are very numerous, have been phylogenetically conserved, and involved in biological processes such as development, differentiation, cell proliferation, and apoptosis. MicroRNAs contribute to modulating the expression levels of specific proteins based on sequence complementarity with their target mRNA molecules and so they play a key role in both health and disease. Angiogenesis is the process of new blood vessel formation from preexisting ones, which is particularly relevant to cancer and its progression. Over the last few years, microRNAs have emerged as critical regulat…

Novel Lipid and Polymeric Materials as Delivery Systems for Nucleic Acid Based Drugs

2015

Nucleic acid based drugs (NADBs) are short DNA/RNA molecules that include among others, antisense oligonucleotides, aptamers, small interfering RNAs and micro-interfering RNAs. Despite the different mechanisms of actions, NABDs have the ability to combat the effects of pathological gene expression in many experimental systems. Thus, nowadays, NABDs are considered to have a great therapeutic potential, possibly superior to that of available drugs. Unfortunately, however, the lack of effective delivery systems limits the practical use of NABDs. Due to their hydrophilic nature, NABDs cannot efficiently cross cellular membrane; in addition, they are subjected to fast degradation by cellular and…

Study of the flying geese theory from a political point of view : a Japanese propaganda argument in the post world war II era

2009

The Flying Geese Theory (gankoo keitai hattenron 雁行形態発展論), dating from 1932, is one of the rare cases of a scientific theory that was used as a part of Japanese wartime propaganda, and which also survived and succeeded in the postwar era. It was used to legitimize the 'New Order in East Asia (TōA shinchitsujo 東亜新秩序) in 1938, and the new formulation of the 'Greater East Asia Co-Prosperity Sphere‘ (Dai TōA kyōeiken大東亜共栄圏) in 1940. Later in the 1980s the Flying Geese Theory/Pattern became the most successful candidate for explaining the expansion of ‗Asian economical miracles‘ in the postwar era. This study focuses on this famous piece of economical and political rhetoric. The intention is to …

RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets.

2019

Background MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line. Methods We performed three RIP-Chip experiments using either anti-AGO2 or anti-GW182 antibodies and compiled a data set made up of the miRNA and mRNA expression profiles of three samples for each experiment. Specifically, we analyzed the input sample, the immunoprecipita…

Circulating miRNA expression analysis reveals new potential biomarkers for human cutaneous melanoma staging.

2019

Editorial: The Role of the Muscle Secretome in Health and Disease

2020

myokines, exercise, muscle-derived secreted factors, circulating miRNA, extracellular vesicles

Alterations in Circulating miRNA Levels following Early-Stage Estrogen Receptor-Positive Breast Cancer Resection in Post-Menopausal Women

2014

INTRODUCTION: Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. The aim of this study was to investigate changes in the levels of specific circulating miRNA following breast cancer surgery and evaluate whether these alterations were also observed in an independent data set.METHODS: Global miRNA analysis was performed on prospectively collected serum samples from 24 post-menopausal women with estrogen receptor-positive early-stage breast cancer before surgery and 3 weeks after tumor resection using global LNA-based quantitative real-time PCR (qPCR).RESULTS: Numbers of specific miRNAs detected in the samples ranged fro…

Liquid Biopsy in Diagnosis and Prognosis of High-Grade Gliomas; State-of-the-Art and Literature Review

2022

Gliomas, particularly high-grade gliomas, represent the most common and aggressive tumors of the CNS and are still burdened by high mortality and a very poor prognosis, regardless of the type of therapy. Their diagnosis and monitoring rely on imaging techniques and direct biopsy of the pathological tissue; however, both procedures have inherent limitations. To address these limitations, liquid biopsies have been proposed in this field. They could represent an innovative tool that could help clinicians in the early diagnosis, monitoring, and prognosis of these tumors. Furthermore, the rapid development of next-generation sequencing (NGS) technologies has led to a significant reduction in seq…

Zvaigžņotā Debess: 2000, Rudens (169)

2000

Contents: M.Zepe. Water Steam in the Venus Atmosphere ; B.Sala, L.Kondraševa. Use of Solar Energy ; A.Balklavs. Century Long Astrophysics ; Z.Alksne, A.Alksnis. Plenty of Extrasolar Planets ; Z.Alksne, A.Alksnis. Unexpected Discovery of Spiral Structure in a Dwarf Elliptical Galaxy ; A.Balklavs. Hunting for the Black Holes ; J.Jaunbergs. Private Enterprise on Mir ; T.Czarnik. Surviving Explosive Decompression ; M.Gills. Space Research 40 Years Ago – Chronicle ; M.Krastiņš. Impressions about Rose Center for the Earth and Space ; K.Bērziņš. On Friendly Terms with Cosmology: Basic Principles and Models of the Universe (continuation) ; V.Flerov, A.Cēbers, D.Docenko, V.Kaščejev. Latvia 24th Open…