Search results for "miR"
showing 10 items of 1117 documents
The secularization of Marian miracles in Miquel Peres’ La vida de la Verge Maria
2017
En aquest treball analitze el conjunt de miracles marians inclosos per Miquel Peres en La vida de la sacratíssima Verge Maria (València, N. Spindeler, 1494). Aquest conjunt de miracles no només destaca per la funcionalitat concreta que adquireixen en l’estructura de l’obra, sinó perquè, a més, aquests mostren unes característiques determinades que els allunyen de les col·leccions de miracula marians, ja que no presenten alguns dels trets més significatius del gènere. Els miracles de Miquel Peres constitueixen una mostra de la transformació i la secularització del gènere, i ens parlen dels nous usos que se’n deriven i dels nous lectors a qui s’adrecen. In this paper I discuss the whole of Ma…
Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.
2010
An inflammatory component is present in the microenvironment of most neoplastic tissues, including those not causally related to an obvious inflammatory process. Several microRNAs, and especially miR-155, play an essential role in both the innate and adaptative immune response. Resveratrol (trans-3,4#,5-trihydroxystilbene) is a natural antioxidant with anti-inflammatory properties that is currently at the stage of preclinical studies for human cancer prevention. Here, we establish that, in human THP-1 monocytic cells as well as in human blood monocytes, resveratrol upregulates miR- 663, a microRNA potentially targeting multiple genes implicated in the immune response. In THP-1 cells, miR-66…
Transcriptomic Analyses Reveal 2 and 4 Family Members of Cytochromes P450 (CYP) Involved in LPS Inflammatory Response in Pharynx of Ciona robusta
2021
Cytochromes P450 (CYP) are enzymes responsible for the biotransformation of most endogenous and exogenous agents. The expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, and regulation by cytokines and hormones. In recent years, Ciona robusta, one of the closest living relatives of vertebrates, has become a model in various fields of biology, in particular for studying inflammatory response. Using an in vivo LPS exposure strategy, next-generation sequencing (NGS) and qRT-PCR combined with bioinformatics and in silico analyses, compared whole pharynx transcripts from naïve and LPS-exposed C. robusta…
Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways
2012
Background & Aims: miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory region and characterized its transcriptional regulation by the NFκB-dependent inflammatory pathways. Methods: Mature miRNA expression was evaluated by a 2 step stem-loop real-time RT-PCR. The recruitment of polymerase II and transcription factors on the pre-miR-224 promoter has been assessed by ChIPSeq and ChIP. Results: We found miR-224 levels strongly up-regulated in both peri-tumoral cirrhotic livers and HCC samples as compared to normal livers. In silico analysis of the putative miR-224 promoter r…
Quaking and miR-155 interactions in inflammation and leukemogenesis.
2015
Quaking (QKI) is a tumor-suppressor gene encoding a conserved RNA-binding protein, whose expression is downregulated in several solid tumors. Here we report that QKI plays an important role in the immune response and suppression of leukemogenesis. We show that the expression of Qki is reduced in lipopolysaccharide (LPS)-challenged macrophages, suggesting that Qki is a key regulator of LPS signaling pathway. Furthermore, LPS-induced downregulation of Qki expression is miR-155-dependent. Qki overexpression impairs LPS-induced phosphorylation of JNK and particularly p38 MAPKs, in addition to increasing the production of anti-inflammatory cytokine IL-10. In contrast, Qki ablation decreases Fas …
Magia y milagros de san Paulicio en <em>Arderique</em> (1517): el cadáver del santo, la pareja infecunda y el nacimiento heroico
2019
Arderique es el título de un libro de caballerías castellano, anónimo, publicado en 1517 (Valencia, Juan Viñao). El artículo se centra en la función que desempeña en la obra un personaje, san Paulicio, cuyo auxilio se muestra decisivo en determinados momentos de la acción, empezando por el nacimiento de la heroína del relato. Se estudia el posible entronque de este Paulicio de la ficción con personajes históricos y con las vitae de santos eremitas, como san Pablo de Tebas. Y se estudian, asimismo, los motivos folclóricos que coinciden con las marcas de reconocimiento de la santidad de Paulicio: los leones rastreadores de su cadáver, las campanas tañendo solas y la carta agarrada por una man…
« Making Sense of Wilfred Owen’s Keatsian Heritage: “Exposure” and “Ode to a Nightingale” »
2020
Readers of Wilfred Owen usually agree that the war poet’s early admiration for John Keats faded after he enlisted in the army; his poetry then turned against Keats’s. The opening paraphrase of Owen’s poem “Exposure” is thus often read as a rejection and a subversion of the Romantic poet’s “Ode to a Nightingale.” This essay will argue that Owen’s poem can be seen as a radical reversal of Keats’s ode. While “Exposure” is indeed more violent and political than “Ode to a Nightingale,” it does not depart from Keats’s conception of human suffering and of nature. Instead, the war poem builds on Keats’s fleeting description of suffering humanity in “Ode to a Nightingale” and extends it. It also ech…
Marlowe and Company in Barnfield’s <i>Greene’s Funeralls</i> (1594)
2013
The accomplished and daring but minor poet Richard Barnfield (1574-1620) was among the first poets to engage creatively with the works of Greene, Marlowe, and Shakespeare. This article argues that Sonnet 9 in Barnfield’s Greene’s Funeralls (1594) reveals not only his admiration for these literary innovators, but also his difficult manoeuvres on the fringes of the group of poetic rivals. Barnfield’s often-quoted, but not fully understood “sonnet” reflects the young poet’s attempts to accost his more famous contemporaries and also sheds light on the date of composition of Doctor Faustus (B) and the early circulation of Shakespeare’s “sugred sonnets”.
Joan Roís de Corella, La Istòria de Leànder y Hero: edizione critica con studio introduttivo
2018
This contribution is a further partial anticipation of the critical edition of the mythological faules of Joan Roís de Corella (15th century) for Barcino (ENC), after that appeared in Magnificat, vol.3, 2016. It focuses on one of the author's most mature and significant faules, as well as one of the most prestigious testimonies both of the presence of the myth of Ero and Leandro in the Iberian 15th century, and of the peninsular reception of the Heroides. The paper consists of two parts. In the first part, Introduction, the current situation of the studies related to the Istòria is first summarized. Next, the analysis of the literary memory that supports the discursive construction of the f…