Search results for "miR"
showing 10 items of 1117 documents
The radium Era: radioactivity and advertising of miracle products in the dawn of the 20th century in Spain
2020
El descubrimiento de la radiactividad a finales del siglo XIX proporcionó el conocimiento de un nuevo fenómeno natural que fue utilizado como reclamo sin validación científica en un repertorio de productos, remedios y terapias que en el primer cuarto del siglo XX se anunciaron profusamente en la prensa española. Las experiencias de los manantiales con el agua radiactiva o los emanatorios urbanos fueron algunos de los casos más frecuentes de esas terapias o productos milagro en los que la publicidad de la época utilizaba la ciencia desde el abuso, el desconocimiento o las falsas atribuciones para prometer curaciones para todo tipo de dolencias sin ninguna efectividad práctica. The discovery …
Poisoning histories in the Italian renaissance: The case of Pico Della Mirandola and Angelo Poliziano.
2018
Giovanni Pico della Mirandola and Angelo Poliziano were two of the most important humanists of the Italian Renaissance. They died suddenly in 1494 and their deaths have been for centuries a subject of debate. The exhumation of their remains offered the opportunity to study the cause of their death through a multidisciplinary research project. Anthropological analyses, together with documentary evidences, radiocarbon dating and ancient DNA analysis supported the identification of the remains attributed to Pico. Macroscopic examination did not reveal paleopathological lesions or signs related to syphilis. Heavy metals analysis, carried out on bones and mummified tissues, showed that in Pico's…
RAMOS, Vicente: Rafael. Altamira [Reseña]
1969
Reseña de Rafael Altamira.
Documentos correspondientes al reinado de Ramiro I desde TXXXIV hasta TLXIII años
Índex Text en llatí i castellà
Targeted Therapy Modulates the Secretome of Cancer-Associated Fibroblasts to Induce Resistance in HER2-Positive Breast Cancer
2021
The combination of trastuzumab plus pertuzumab plus docetaxel as a first-line therapy in patients with HER2-positive metastatic breast cancer has provided significant clinical benefits compared to trastuzumab plus docetaxel alone. However, despite the therapeutic success of existing therapies targeting HER2, tumours invariably relapse. Therefore, there is an urgent need to improve our understanding of the mechanisms governing resistance, so that specific therapeutic strategies can be developed to provide improved efficacy. It is well known that the tumour microenvironment (TME) has a significant impact on cancer behaviour. Cancer-associated fibroblasts (CAFs) are essential components of the…
Modelling genetic regulation of growth and form in a branching sponge
2008
We present a mathematical model of the genetic regulation controlling skeletogenesis and the influence of the physical environment on a branching sponge with accretive growth (e.g.Haliclona oculataorLubomirskia baikalensis). From previous work, it is known that high concentrations of silicate induce spicule formation and upregulate thesilicateingene. The upregulation of this gene activates locally the production of spicules in the sponge and the deposition of the skeleton. Furthermore, it is known that the expression of the geneIroquoisinduces the formation of an aquiferous system, consisting of exhalant and inhalant pores. We propose a model of the regulatory network controlling the separa…
Maisema kohtaamispaikkana Mirkka Rekolan kokoelmissa Kohtaamispaikka vuosi ja Maailmat lumen vesistöissä
2014
Une ébauche des Miranda de laudibus Francie de Bernard de Rosier († 1475) dans un recueil de consultations de la Bibliothèque nationale universitaire…
2020
Bien connues sont la vie et la carrière de l’archevêque de Toulouse Bernard de Rosier (1400-1475), un ambitieux brillant, qui a mené de pair le service du Saint-Siège, l’enseignement universitaire et l’administration diocésaine. Aux yeux de l’historien du droit et des idées politiques, il est avant tout un canoniste et un auteur politique des plus marquants du XVe siècle français. Pour son engagement contre la politique royale exprimée dans la Pragmatique Sanction de Bourges de 1438, il a san...
Grasp-specific motor resonance is influenced by the visibility of the observed actor
2016
AbstractMotor resonance is the modulation of M1 corticospinal excitability induced by observation of others' actions. Recent brain imaging studies have revealed that viewing videos of grasping actions led to a differential activation of the ventral premotor cortex depending on whether the entire person is viewed versus only their disembodied hand. Here we used transcranial magnetic stimulation (TMS) to examine motor evoked potentials (MEPs) in the first dorsal interosseous (FDI) and abductor digiti minimi (ADM) during observation of videos or static images in which a whole person or merely the hand was seen reaching and grasping a peanut (precision grip) or an apple (whole hand grasp). Part…
Time-dependent resonance interaction energy between two entangled atoms under nonequilibrium conditions
2018
We consider the time-dependent resonance interaction energy between two identical atoms, one in the ground state and the other in an excited state, and interacting with the vacuum electromagnetic field, during a nonequilibrium situation such as the dynamical atomic self-dressing process. We suppose the two atoms prepared in a correlated, symmetric or antisymmetric, state. Since the atoms start from a nonequilibrium conditions, their interaction energy is time dependent. We obtain, at second order in the atom-field coupling, an analytic expression for the time-dependent resonance interaction energy between the atoms. We show that this interaction vanishes when the two atoms are outside the l…