Search results for "miR"
showing 10 items of 1117 documents
miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.
2010
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of different genes, including genes involved in cancer progression. A functional link between hypoxia, a key feature of the tumor microenvironment, and miRNA expression has been documented. We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor (VEGF) in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions (CoCl(2) exposure). Using immunoblotting, ELISA, and quantitative real-time PCR, we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl(2) treatment, and VEGF mRNA at 4 h of treatment. In addition, miR-20b reduce…
Rethinking Samir Amin’s legacy and the case for a political organization of the global justice movement
2019
Juego argues that the new Internationale’s “primary organizational function should be the global coordination of actions of progressive grassroots movements from country to country.” He calls for a ‘learning organization,’ where the new Internationale supports “a continuous dialogue between bottom-up and top-down approaches to decision-making.” He sees it as “[a]kin to a global coordinating council” meaning that it works to integrate and synthesize the “varying initiatives, campaigns, and mass actions at all geographical levels of membership” while remaining mindful of the “dialectics between reform and revolution.” The new Internationale must, moreover, be “grounded on a pragmatic understa…
Pētera šmita vēstule latviešu un lietuviešu folkloristam, etnogrāfam Eduardam Volteram
1912
Vēstulē P. Šmits runā par latviešu mitoloģiju, tautas dziesmām, piemin A. Bīlenšteina darbu par latviešu koka celtnēm, lietuviešu valodnieku K. Būgu, kā arī interesi par citu tautu folkloru, priecātos par E. Voltera viedokli par saviem rakstiem, lūdz atsūtīt veco katoļu Katehismu.
Collective Intentionality, Methodological Solipsism, and Current Neurosciences.
2008
L’intervento analizza la teoria searleana dell’intenzionalità collettiva e la sua pretesa di superamento della dicotomia tra approcci individualisti (riduzionisti) e collettivisti all’intenzionalità collettiva considerandone la plausibilità alla luce della recente scoperta dei mirror neurons (interpretata alla luce delle teorie di Gallese e Rizzolatti) e della più generale concezione della mente come sistema autonomo modulato dall’ambiente quale emerge dalle teorie di Edelman e Llinàs.
Recognizing actions with the associative self-organizing map
2013
When artificial agents interact and cooperate with other agents, either human or artificial, they need to recognize others’ actions and infer their hidden intentions from the sole observation of their surface level movements. Indeed, action and intention understanding in humans is believed to facilitate a number of social interactions and is supported by a complex neural substrate (i.e. the mirror neuron system). Implementation of such mechanisms in artificial agents would pave the route to the development of a vast range of advanced cognitive abilities, such as social interaction, adaptation, and learning by imitation, just to name a few. We present a first step towards a fully-fledged int…
Can Be miR-126-3p a Biomarker of Premature Aging? An Ex Vivo and In Vitro Study in Fabry Disease
2021
Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by lysosomal accumulation of glycosphingolipids in a wide variety of cytotypes, including endothelial cells (ECs). FD patients experience a significantly reduced life expectancy compared to the general population
Yet Another New Variant of Szász–Mirakyan Operator
2021
In this paper, we construct a new variant of the classical Szász–Mirakyan operators, Mn, which fixes the functions 1 and eax,x≥0,a∈R. For these operators, we provide a quantitative Voronovskaya-type result. The uniform weighted convergence of Mn and a direct quantitative estimate are obtained. The symmetry of the properties of the classical Szász–Mirakyan operator and of the properties of the new sequence is investigated. Our results improve and extend similar ones on this topic, established in the last decade by many authors.
Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor
2003
Antidepressants are commonly supposed to enhance serotonergic and/or noradrenergic neurotransmission by inhibition of neurotransmitter reuptake through binding to the respective neurotransmitter transporters or through inhibition of the monoamine oxidase. Using the concentration-clamp technique and measurements of intracellular Ca2+, we demonstrate that different classes of antidepressants act as functional antagonists at the human 5-HT3A receptor stably expressed in HEK 293 cells and at endogenous 5-HT3 receptors of rat hippocampal neurons and N1E-115 neuroblastoma cells. The tricyclic antidepressants desipramine, imipramine, and trimipramine, the serotonin reuptake inhibitor fluoxetine, t…
Spazio alle nuove specie: actinidia, piccoli frutti, tropicali
2018
Dopo il grande successo dell’actinidia sono stati tanti i tentativi di portare in Italia nuove specie da frutto per diversicare il panorama produttivo di aree in crisi strutturale e commerciale con le colture più tradizionali. Il Centro-Nord ha puntato sui piccoli frutti, ora il Sud punta alle specie sub-tropicali. Il mercato ha voglia di novità, ma non tutto si presta ad una diffusione su larga scala.
Order Orthoptera: additions to the Orthoptera fauna of the UAE
2014
Orthoptera of UAE were recently summarized by Massa et al (2010). We report here additional records of species collected by Anthonius van Harten with different methods in 2004-2007 and by F.M. Buzzetti in March 2010 during a collecting expedition to UAE, within the framework of the Arthropod of the UAE project.