Search results for "miR"
showing 10 items of 1117 documents
Utilización de microRNAs como dianas terapéuticas en Distrofia Miotónica
2018
La distrofia miotónica tipo 1 (DM1) se debe a una expansión del triplete CTG en 3´UTR del gen DMPK, mientras que, la distrofia miotónica tipo 2 (DM2) se origina por la de la repetición CCTG en el intrón 1 del gen CNBP. Son dos enfermedades multisistémicas con manifestaciones patológicas en músculo esquelético (miotonia, degeneración y debilidad muscular), corazón (defectos en la conducción cardiaca) y sistema nervioso central. Los transcritos DMPK y CNBP mutantes se pliegan en horquillas que secuestran factores de splicing alternativo, principalmente Muscleblind-like 1 (MBNL1; y su parálogo MBNL2). La falta de la proteínas MBNL origina problemas en el splicing de transcritos musculares y co…
La rappresentazione dei prodigia nelle orazioni politiche di Temistio fra arte allusiva e parenesi morale
2017
In questo articolo vengono esaminati alcuni aspetti peculiari del magico (γοητεία), del soprannaturale (τέρας), del meraviglioso (θαυμαστός) e del paradossale (παράδοξον) nelle Orazioni 4, 7, 11, 16 e 29 di Temistio. La rappresentazione allusiva dei prodigia è fortemente influenzata dalla tradizione letteraria nota all’autore, ma la loro dimensione metaforica consente di trattarli come exempla adatti a favorire la riflessione politica e morale sul tema dell’optimus princeps. This article examines some peculiar features of magic (γοητεία), supernatural (τέρας), marvellous (θαυμαστός) and paradoxical (παράδοξος) in Themistius’ Orations 4, 7, 11, 16 and 29. Here the allusive depiction of prodi…
Analytical design of nonlinear optical loop mirrors for fiber-optic communication systems
2006
International audience; We propose an easy and efficient method for analytically designing nonlinear optical loop mirrors (NOLMs) for fiber-optic communication systems. This analytical design is based on a Taylor series expansion of the transfer function of the NOLM, from which highly stable dynamical regimes can be readily obtained for any desired pulse parameters. We present numerical simulations showing dramatically improved performances in a 160 Gb/s transmission system that incorporates the NOLMs designed analytically.
Influence of spectral composition on the temperature coefficients of solar cells from Elkem Solar
2014
The temperature coefficients of solar cells from two different feedstocks — a compensated silicon, the Elkem Solar Silicon (ESS®), and polysilicon - under full and selective parts of the light spectrum are presented based on results obtained using a AAA sun simulator. These results are of particular interest in understanding the possible causes behind the better temperature coefficients usually observed for ESS® compared to polysilicon solar cells when measured with a full AM1.5 spectrum. The optical filtered lights from four different regions of the spectrum have been used to examine the influence of temperature coefficients on the spectral composition. ESS® solar cells showed considerable…
Properties and constraints of cheating-immune secret sharing schemes
2006
AbstractA secret sharing scheme is a cryptographic protocol by means of which a dealer shares a secret among a set of participants in such a way that it can be subsequently reconstructed by certain qualified subsets. The setting we consider is the following: in a first phase, the dealer gives in a secure way a piece of information, called a share, to each participant. Then, participants belonging to a qualified subset send in a secure way their shares to a trusted party, referred to as a combiner, who computes the secret and sends it back to the participants.Cheating-immune secret sharing schemes are secret sharing schemes in the above setting where dishonest participants, during the recons…
Radial phononic thermal conductance in thin membranes in the Casimir limit: Design guidelines for devices
2014
In a previous publication, we discussed the formalism and some computational results for phononic thermal conduction in the suspended membrane geometry for radial heat flow from a central source, which is a common geometry for some low-temperature detectors, for example. We studied the case where only diffusive surface scattering is present, the so called Casimir limit, which can be experimentally relevant at temperatures below $\sim$ 10 K in typical materials, and even higher for ultrathin samples. Here, we extend our studies to much thinner membranes, obtaining numerical results for geometries which are more typical in experiments. In addition, we interpret the results in terms of a small…
Dicaesium silver zinc thiocyanate, Cs2[AgZn(SCN)5]
2001
The title compound, dicaesium(I)-μ-thiocyanato-κ2N:S-zinc(II)-tetra-μ-thiocyanato-κ2S:N-argentate(I), crystallizes in the orthorhombic space group Pmn21 and contains units of composition AgZn(SCN)3 lying on a mirror plane and bonded together through Cs+ ions and thiocyanate groups. The crystal studied contained equal numbers of inversion twins.
Una storia italiana: Giorgio e Isabella
2018
Si tratta, qui, della storia di due italiani dalla “pelle scura” raccontata, per Giorgio Marincola, da Carlo Costa e Lorenzo Teodonio in Razza partigiana e, per la sorella Isabella, da Wu Ming 2 e Antar Mohamed in Timira. Romanzo meticcio. Le loro vicende, così come molti altri aspetti della nostra storia coloniale, neocoloniale e postcoloniale, sono riemerse dal buio nel quale erano state occultate solo nell’ultimo quindicennio, grazie alla riapertura degli archivi che ha permesso di ridiscutere molti degli aspetti che nelle pagine di Storia, così come in quelle letterarie, erano stati raccontati in altro modo. I due testi, che hanno inevitabilmente finito per incontrarsi e che potremmo in…
Tiesību tikt aizmirstam regulējums Eiropas Savienībā
2018
21.gadsimts ir straujo tehnoloģiju attīstības laikmets, kas met izaicinājumus personu privātuma aizsardzībai. Regulas 2016/679 piemērošana ievesīs inovācijas personas datu apstrādes un aisardzības jomā – tai skaitā Regulā 2016/679 nostiprinātās tiesības tikt aizmirstam. Tiesības tikt aizmirstam, kā viens no privātuma aizsardzības mehānismiem, līdzsvaros datu subjekta tiesības un datu pārziņa pienākumus. Darba mērķis ir izpētīt tiesību tikt aizmirstam jēdzienu un tvērumu, kā arī tiesību tikt aizmirstam Regulā 2016/679 un Latvijas normatīvajos aktos ietverto regulējumu. Īpaša kritika ir vērsta uz tiesību tikt aizmirstam jēdzienu EST spriedumā Google Spain lietā.
An overview of the clinical efficacy of mirtazapine
2002
Mirtazapine is at least as effective as the tricyclic antidepressants and trazodone in a wide range of patient subgroups including in- and out-patients with moderate to severe depression. It also appears to be at least as effective as the serotonin and noradrenaline reuptake inhibitor venlafaxine in the treatment of severely depressed melancholic patients. When compared with the selective serotonin reuptake inhibitors (SSRIs), mirtazapine shows a significantly earlier onset of action. Further analysis of a study comparing mirtazapine with the SSRI paroxetine indicated that early improvement was a highly sensitive predictor of later stable response for both drugs. The positive predictive val…