Search results for "miR"
showing 10 items of 1117 documents
Study of the epi- / genomic dysregulation of breast cancer in women under 35 years and evaluation of cellular models
2019
El cáncer de mama tiene la tasa de incidencia más alta de todos los cánceres en mujeres en todo el mundo. Este cáncer suele tener un excelente pronóstico con un 80% de supervivencia. Aunque las mujeres menores de 35 años representan el 3-4% del total de casos diagnosticados, sus tumores se caracterizan por ser más grandes, más proliferativos y con una mayor representación de subtipos más agresivos y de peor pronóstico. Las transformaciones neoplásicas se asocian con alteraciones en la metilación del ADN, que incluyen tanto la hipometilación global como la hipermetilación específica. Por otro lado, los miRNAs son pequeñas moléculas no codificantes con un papel importante en la regulación de …
La distribution des tuiles estampillées de la VIIIe légion Augusta autour de Mirebeau-sur-Bèze (Côte-d'Or, France)
2011
The 8th Augustan Legion was installed at Mirebeau-sur-Bèze (Côte-d'Or) after 70 AD following the troubles that arose with the Lingons. It remained there until the time of Domitian, a period of roughly twenty years, during which time the soldiers produced tiles stamped with the name of the legion. Analysis of the dispersion of the tiles in the region around Mirebeau shows that they followed the communication routes. Consideration of the contexts in which these tiles were used, their number on each site and the resources necessary to manufacture them reveals that the 8th Legion may have played a significant role in the diffusion and adoption of tiled roofs, a construction technique that was t…
Genetic and Molecular Characterization of The Human Osteosarcoma 3AB-OS Cancer Stem Cell Line: A Possible Model For Studying Osteosarcoma Origin and …
2013
Finding new treatments targeting cancer stem cells (CSCs) within a tumor seems to be critical to halt cancer and improve patient survival. Osteosarcoma is an aggressive tumor affecting adolescents, for which there is no second-line chemotherapy. Uncovering new molecular mechanisms underlying the development of osteosarcoma and origin of CSCs is crucial to identify new possible therapeutic strategies. Here, we aimed to characterize genetically and molecularly the human osteosarcoma 3AB-OS CSC line, previously selected from MG63 cells and which proved to have both in vitro and in vivo features of CSCs. Classic cytogenetic studies demonstrated that 3AB-OS cells have hypertriploid karyotype wit…
Impact of periodontal treatment on GCF miRNAs expression changes associated with cardiovascular risk in patients with periodontitis
2022
Prognostic Impact of let-7e MicroRNA and Its Target Genes in Localized High-Risk Intestinal GIST: A Spanish Group for Research on Sarcoma (GEIS) Study
2020
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin tumor blocks of 14 and 86 patients were used in the discovery and expansion sets, respectively. GeneChip miRNA v3.0 was employed to identify the miRNAs differentially expressed between relapsed and non-relapsed patient samples, which were validated in the expansion set, by qRT-PCR. RT2 Profiler PCR Array was used for the screening of let-7e targets. Expression levels were co…
Disabilità visiva e neuroni specchio
2009
Il seguente lavoro ha come obiettivo quello indagare, il possibile coinvolgimento del sistema dei neuroni specchio nella disabilità visiva, cercando di analizzare, in particolare, come il soggetto non vedente possa comprendere e conoscere l’azione degli altri privato dal corpus di informazioni provenienti dal canale visivo. L’ipotesi da verificare è se nei soggetti con disabilità visiva e nei soggetti con sviluppo tipico venga messo in gioco e con quale modalità, lo stesso sistema di neuroni specchio unitario (visivo-uditivo) per il riconoscimento dell’azione. Inoltre, lo studio dovrebbe consentire di verificare se la disabilità visiva ad esordio precoce (congenita) è in grado di aumentare …
The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells
2020
Migration of glioblastoma cells into surrounding tissue is one of the main features that makes this tumor incurable. We evaluated whole-genome miRNA expression profiling associated with different EGFR amplification patterns in 30 cases of primary glioblastoma. From the 64 miRNAs that showed differential expression between tumors with a high level of EGFR amplification and tumors without EGFR amplification, 40% were related with cell migration, being miR-200c the most differentially expressed between these two groups. We investigated the effect of miR-200c on ZEB1 expression and cell migration in an in vitro transfection model with a miR-200c mimic, a miR-200c inhibitor and siRNA targeting E…
La charte de Pierre de Brixey, évêque de Toul, pour le prieuré de Bainville-aux-Miroirs (1170)
2004
International audience
Reply to “Mirror Symmetry Breaking” of the Centrosymmetric CaCO3 Crystals with Amino Acids
2008
Characterization of a fiber-reinforced new fully aromatic liquid crystalline polymer
1998
A new rigid liquid crystalline polymer that demonstrates good mechanical and thermomechanical properties and acceptable processing temperature has been recently synthesized and characterized. The melting temperature and some thermomechanical properties do not seem, however, suitable for use in some applications at high temperature or in the presence of aggressive fluids. The use of appropriate inorganic fillers can overcome these shortcomings. In this work the new LCP, polymerized in a bench-scale apparatus, and the same sample filled with carbon fibers are characterized. The properties of the carbon fiber filled LCP are compared with those of another filled wholly aromatic commercial LCP,…