Search results for "microPET"

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Quantification of the Cannabinoid Type 1 Receptor Availability in the Mouse Brain

2020

Introduction: The endocannabinoid system is involved in several diseases such as addictive disorders, schizophrenia, post-traumatic stress disorder, and eating disorders. As often mice are used as the preferred animal model in translational research, in particular when using genetically modified mice, this study aimed to provide a systematic analysis of in vivo cannabinoid type 1 (CB1) receptor ligand-binding capacity using positron emission tomography (PET) using the ligand [18F]MK-9470. We then compared the PET results with literature data from immunohistochemistry (IHC) to review the consistency between ex vivo protein expression and in vivo ligand binding.Methods: Six male C57BL/6J (6–9…

0301 basic medicineCannabinoid receptormedicine.medical_treatmentNeuroscience (miscellaneous)PharmacologyBiologylcsh:RC321-571lcsh:QM1-69503 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineIn vivoRadioligandmedicine[18F]MK-9470 ; cannabinoid type 1 receptor ; immunohistochemistry ; microPET ; mouseReceptorlcsh:Neurosciences. Biological psychiatry. NeuropsychiatrymouseOriginal ResearchCerebrumlcsh:Human anatomyLigand (biochemistry)microPETEndocannabinoid system[18F]MK-9470030104 developmental biologymedicine.anatomical_structurenervous systemcannabinoid type 1 receptorimmunohistochemistryCannabinoidAnatomy030217 neurology & neurosurgeryNeuroscienceFrontiers in Neuroanatomy
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