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More than Pneumonia: Distinctive Features of SARS-Cov-2 Infection. From Autopsy Findings to Clinical Implications: A Systematic Review

2020

Despite safety recommendations for the management of corpses with COVID-19 infection and the high number of deaths worldwide, the post-mortem investigation rate is extremely low as well as the scientific contributions describing the pathological features. The first results of post-mortem investigations provided interesting findings and contributed to promoting unexplored therapeutic approaches and new frontiers of research. A systematic review is provided with the aim of summarizing all autopsy studies up to February 2020 in which a complete post-mortem investigation in patients with COVID-19 disease was performed, focusing on histopathological features. We included case reports, case serie…

Microbiology (medical)medicine.medical_specialtyARDSAutopsyReviewDisease030204 cardiovascular system & hematologyCytokine stormMicrobiology03 medical and health sciences0302 clinical medicineautopsyVirologymedicineMedical historydiffuse alveolar damage (DAD)acute kidney injury (AKI)Intensive care medicineProspective cohort studyPathologicallcsh:QH301-705.5COVID-19; autopsy; diffuse alveolar damage (DAD); acute respiratory distress syndrome (ARDS); microthrombosis; acute kidney injury (AKI); cytokine stormmicrothrombosisbusiness.industryGold standardacute respiratory distress syndrome (ARDS)COVID-19medicine.diseasePneumonialcsh:Biology (General)030220 oncology & carcinogenesiscytokine stormmicrothrombosibusinessMicrothrombosis.Microorganisms
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