Search results for "microvascular"
showing 10 items of 72 documents
A multicenter survey on access to care in Multiple Sclerosis-related trigeminal neuralgia
2021
The prevalence of trigeminal neuralgia (TN) in patients with Multiple Sclerosis (MS) is higher than in the general population and its management can be particularly challenging due to a number of reasons including high recurrence rates, lack of MS-specific treatment guidelines and uncertainties about pain pathophysiology. Aim of this cross-sectional, multicentre survey was to gather information on the current treatment modalities and options of MS-related TN across 23 Italian MS centres. Initial medical management (carbamazepine or oxcarbazepine) of MS-related TN was fairly homogeneous throughout Italian centres. The most commonly available surgical procedure was microvascular decompression…
Estudio de los mecanismos básicos y el diagnóstico del daño microvascular tras un infarto agudo de miocardio. Exploración de nuevas oportunidades ter…
2022
El infarto agudo de miocardio (IAM) constituye una de las principales causas de morbilidad y mortalidad en las sociedades occidentales. A pesar de que se han hecho grandes avances en el tratamiento gracias a la reperfusión coronaria por métodos percutáneos, entre el 30-50% de los pacientes presentan un daño severo en la microcirculación conocido como obstrucción microvascular (OMV). Este fenómeno ejerce efectos negativos en cuanto a la estructura y pronóstico de los pacientes con IAM con elevación del segmento ST (IAMEST). Por ello, el principal objetivo de la presente Tesis Doctoral es avanzar en el entendimiento de los mecanismos y el diagnóstico del daño microvascular tras un IAMEST así …
Endothelial Function and Arterial Stiffness in Uncomplicated Type 1 Diabetes and Healthy Controls and the Impact of Insulin on These Parameters durin…
2007
BACKGROUND In addition to its role in glucose metabolism, insulin has shown to exert numerous vascular effects, and an impaired vascular function of insulin is assumed to be a major contributor in the development of vascular complications. Arterial augmentation (AP) and the augmentation index (Aix) are surrogate parameters of arterial stiffness and are commonly used as predictors for cardiovascular risk. The aim of this study is to investigate the effect of insulin on arterial stiffness and parameters of endothelial function in patients with type 1 diabetes and healthy control subjects. METHODS Fourteen patients with type 1 diabetes (six male, eight female) with a mean age of 36.6 +/- 11.8 …
Predictors of microvascular complications in type 1 diabetic patients at onset: The role of metabolic memory
2011
Background Several epidemiological studies showed a close association between metabolic control and microvascular complications in type 1 Diabetes Mellitus (T1DM). The aim of our longitudinal observational study was to evaluate the predictive role of the main clinical and biochemical parameters in determining microvascular complications. Methods 376 T1DM patients, hospitalized in our division from 1991 to 2005 (mean follow-up = 10.93 ± 4.26 years) were studied. Stepwise Cox regression analysis was used to identify the influence of residual ß-cell function, ß-cell autoimmunity, HbA1c levels and other clinical and laboratory parameters in the development of microalbuminuria and retinopathy. R…
Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts
1999
The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than …
Landmarks for vertebral artery repositioning in bulbar compression syndrome: anatomic and microsurgical nuances
2004
Abstract OBJECTIVE: The purpose of this study was to better elucidate the anatomic relationship between the vertebral artery (VA) along with its perforating vessels and the brainstem to develop anatomic guidelines that would be helpful when decompressing medulla oblongata compressed by the VA. METHODS: Microanatomy dissection was performed in six formalin-fixed cadaveric heads. The VA, posteroinferior cerebellar artery (PICA), anteroinferior cerebellar artery (AICA), and lower brainstem perforators were examined under magnification using a surgical microscope. The outer diameters of the VA, PICA, and AICA were measured. The distance between the VA, lying within the lateral cerebellomedullar…
[Oral capillaroscopy: a new diagnostic method].
2011
The morphological-functional study of microcirculation is of fundamental importance; in fact, the microvascular bed is directly involved both in autoimmune etiopathogenesis pathologies, and in acute and chronic inflammatory etiopathogenesis pathologies. Oral capillaroscopy is a very stimulating method for studying microcirculation, because of the possibility of studying small vessels in vivo by means of a microscope. Today, it is becoming more reliable thanks to the improvement of the observation tools (photography, videomicroscopy).
Comparison of coronary artery flow impairment in diabetic and ipertensive patients with stable microvascular angina
2014
OBJECTIVE: Stable microvascular angina (SMVA) describes patients with angina, findings compatible with myocardial ischemia and normal coronary angiograms. The aim of this study was to evaluate the impact of diabetes on the coronary microcirculation troughs angiography indexes (TIMI Frame Count, Myocardial Blush Grade, Total Myocardial Blush Score) and a new index:TotalTIMI Frame Count (TTFC). PATIENTS AND METHODS: The study population included 310 patients with SMVA that we split into two populations: diabetic-non hypertensive (164 patients) and non-diabetichypertensive (146 patients). We calculated, on angiographic images of each patient, TIMI Frame Count (TFC), Myocardial Blush Grade (MBG…
Analysis of normal human retinal vascular network architecture using multifractal geometry
2017
AIM To apply the multifractal analysis method as a quantitative approach to a comprehensive description of the microvascular network architecture of the normal human retina. METHODS Fifty volunteers were enrolled in this study in the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and January 2014. A set of 100 segmented and skeletonised human retinal images, corresponding to normal states of the retina were studied. An automatic unsupervised method for retinal vessel segmentation was applied before multifractal analysis. The multifractal analysis of digital retinal images was made with computer algorithms, applying the standard box-counting method. Statistical analyse…
Obstrucción microvascular derivada de la resonancia margnética cardiaca tras un infarto miocárdico con elevación del ST –asociación con marcadores de…
2013
Este trabajo, que se dividió en tres partes, pretendió determinar la asociación entre la obstrucción microvascular (MVO) estimada mediante resonancia magnética cardiaca (RMC) con determinados marcadores ampliamente disponibles en el contexto del infarto agudo de miocardio con elevación del segmento-ST (IAMCEST). La RMC permite una exhaustiva evaluación de los pacientes con IAMCEST. En este sentido, la aparición de MVO ha mostrado ser un factor asociado a episodios cardiovasculares adversos mayores y remodelado negativo tras un IAMCEST. En la primera parte de este trabajo, pretendimos explorar la asociación entre el sumatorio de las derivaciones con ST elevado (sum-ST) y la resolución del se…