Search results for "migration"
showing 10 items of 1709 documents
PASSING IDENTITY AND ETHNIC CULTURE IN LATVIAN EMIGRANT FAMILIES
2021
The paper discusses the problem of preserving native Latvian language and the transfer of cultural identity in Latvian diaspora. One of the central tasks for Latvia’s diaspora policy is to support preservation of Latvian language and culture in diaspora with the aim of strengthening the Latvian identity and the sense of belonging to Latvia. Support is provided to diaspora schools for preserving Latvian language, culture and identity outside of Latvia. However, for children not to lose their Latvian language skills it is important that the language is used also in the family.This paper uses a combination of a quantitative survey and in-depth interviews with the parents of children in diaspor…
Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells
2013
Cigarette smoke represents the major risk factor for chronic obstructive pulmonary disease (COPD). Cigarette smoke extracts (CSE) alter TLR4 expression and activation in bronchial epithelial cells. Carbocysteine, an anti-oxidant and mucolytic agent, is effective in reducing the severity and the rate of exacerbations in COPD patients. The effects of carbocysteine on TLR4 expression and on the TLR4 activation downstream events are largely unknown. This study was aimed to explore whether carbocysteine, in a human bronchial epithelial cell line (16-HBE), counteracted some pro-inflammatory CSE-mediated effects. In particular, TLR4 expression, LPS binding, p21 (a senescence marker), IL-8 mRNA and…
Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease
2013
Background Glucocorticoid functions are markedly impaired in patients with chronic obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor roflumilast N-oxide (RNO) is the active metabolite of roflumilast approved as a treatment to reduce the risk of exacerbations in patients with severe COPD. Objective We sought to characterize the differential effects of RNO versus corticosteroids and their potential additive/synergistic effect in neutrophils from patients with COPD, thus providing scientific rationale for the combination of roflumilast with corticosteroids in the clinic. Methods Peripheral blood neutrophils were isolated from patients with COPD (n = 32), smokers (n = 7), …
MIF from mussel: coding sequence, phylogeny, polymorphism, 3D model and regulation of expression.
2012
Abstract Three macrophage migration inhibitory factor (MIF)-related sequences were identified from a Mytilus galloprovincialis EST library. The consensus sequence included a 5′-UTR of 32 nucleotides, the complete ORF of 345 nucleotides, and a 3′-UTR of 349 nucleotides. As for other MIFs, M. galloprovincialis ORF does not include any signal or C-terminus extensions. The translated sequence of 115 amino acids possesses a molecular mass of 12,681.4, a pI of 6.27 and a stability index of 21.48. Its 3D structure resembles human MIF except for one shorter α-helix. Although evolutionary separated from ticks and vertebrates, Mg-MIF appeared to be closely related to Pinctada fucata and Haliotis, but…
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.
2001
The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and in the developing mouse brain. The shedding of L1 involved a disintegrin and metalloproteinase (ADAM)10, as transfection with dominant-negative ADAM10 completely abolishes L1 release. L1-transfected CHO cells (L1-CHO) showed enhanced haptotactic migration on fibronectin and laminin, which was blocked …
Obcy czy inni? Czesi w Zelowie
2018
We wstępnej części artykułu zostaną zaprezentowane kategorie OBCY, INNY oraz SWÓJ w różnych konfiguracjach (opozycja komplementarna, triada), obecnych w dyskursie tożsamościowym. Następnie przedstawione zostaną determinanty tożsamości: konfesja i język grupy mieszkańców Zelowa – potomków czeskich emigrantów religijnych. W końcowej części artykułu podkreśla się, że obraz potomków czeskich emigrantów jest zmienny w czasie: początkowo była to grupa homogeniczna pod względem wyznaniowym, etnicznym i językowym, a obecnie jest grupą zasymilowaną językowo i kulturowo.
Bosnia and Herzegovina: assessing health systems capacity to manage large influx of refugees and migrants. Joint report on a mission of the Health Au…
2020
The large numbers of refugees and migrants arriving in and transiting through Bosnia and Herzegovina pose new challenges to the health system, which must adapt and respond to the needs of both migrants and residents. This requires an efficient policy dialogue between the main stakeholders to share experiences and identify best practices. The WHO Regional Office for Europe, through the Migration and Health programme, supports Member States for strengthening the health sector's capacity to provide evidence-informed responses to the public health challenges for refugee and migrant health. In this regard, a joint assessment mission was carried out in Bosnia and Herzegovina in 2019, using the WH…
Fuel inventory and material migration of JET main chamber plasma facing components compared over three operational periods
2020
Fuel retention and material migration results from JET ITER-like wall beryllium limiter tiles are presented for three operating periods. Ion beam analysis results support the general picture of erosion during limiter configurations with local deposition on tile ends far into the scrape off layer. Similar trends of fuel concentrations are observed in all JET operating periods; (i) low on surfaces exposed to high heat flux and erosion and (ii) higher in deposits. The pattern of fuel retention and deposition correlates with heat flux and distribution of limiter plasmas touching inner and outer limiters. The D/Be ratio in the thickest deposit is similar to 0.01. Global fuel retention attributed…
Refugee and migrant health in Bosnia and Herzegovina: the role of WHO in complex political environments
2019
Nowadays, refugees and migrants are the focus of intense political debate worldwide. From the public health perspective, population movement, including forced migration, is a complex phenomenon and is a high priority on the political and policy agenda of most WHO Member States. Health diplomacy and the health of refugees and migrants are intrinsically linked. Human mobility is relevant to all countries and creates important challenges in terms of both sustainable development and human rights, to ensure equality and achieve results through the Sustainable Development Goals. This book is part of the WHO Regional Office for Europe’s commitment to work for the health of refugees and migrants. I…
Negotiating the inclusion of health in the Global Compact for Safe, Orderly and Regular Migration: from the New York Declaration to the adoption of t…
2019
Nowadays, refugees and migrants are the focus of intense political debate worldwide. From the public health perspective, population movement, including forced migration, is a complex phenomenon and is a high priority on the political and policy agenda of most WHO Member States. Health diplomacy and the health of refugees and migrants are intrinsically linked. Human mobility is relevant to all countries and creates important challenges in terms of both sustainable development and human rights, to ensure equality and achieve results through the Sustainable Development Goals. This book is part of the WHO Regional Office for Europe’s commitment to work for the health of refugees and migrants. I…