Search results for "mining"

Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.

2006

Platelet activation causes conformational changes of integrin GPIIb/IIIa (α IIb β 3 ), resulting in the exposure of its ligand-binding pocket. This provides the unique possibility to design agents that specifically block activated platelets only. We used phage display of single-chain antibody (scFv) libraries in combination with several rounds of depletion/selection to obtain human scFvs that bind specifically to the activated conformation of GPIIb/IIIa. Functional evaluation of these scFv clones revealed that fibrinogen binding to human platelets and platelet aggregation can be effectively inhibited by activation-specific scFvs. In contrast to clinically used GPIIb/IIIa blockers, which ar…

Anti-metastatic activity of heparin is probably associated with modulation of SDF-1-CXCR4 axis

2006

Impact of trace metals from past mining on the aquatic ecosystem: a multi-proxy approach in the Morvan (France).

2014

10 pages; International audience; This study seeks to determine to what extent trace metals resulting from past mining activities are transferred to the aquatic ecosystem, and whether such trace metals still exert deleterious effects on biota. Concentrations of Cd, Cu, Pb and Zn were measured in streambed sediments, transplanted bryophytes and wild brown trout. This study was conducted at two scales: (i) the entire Morvan Regional Nature Park and (ii) three small watersheds selected for their degree of contamination, based on the presence or absence of past mining sites. The overall quality of streambed sediments was assessed using Sediment Quality Indices (SQIs). According to these standar…

Boosting Design Space Explorations with Existing or Automatically Learned Knowledge

2012

During development, processor architectures can be tuned and configured by many different parameters. For benchmarking, automatic design space explorations (DSEs) with heuristic algorithms are a helpful approach to find the best settings for these parameters according to multiple objectives, e.g. performance, energy consumption, or real-time constraints. But if the setup is slightly changed and a new DSE has to be performed, it will start from scratch, resulting in very long evaluation times. To reduce the evaluation times we extend the NSGA-II algorithm in this article, such that automatic DSEs can be supported with a set of transformation rules defined in a highly readable format, the fuz…

Evaluation of Record Linkage Methods for Iterative Insertions

2009

Summary Objectives: There have been many developments and applications of mathematical methods in the context of record linkage as one area of interdisciplinary research efforts. However, comparative evaluations of record linkage methods are still underrepresented. In this paper improvements of the Fellegi-Sunter model are compared with other elaborated classification methods in order to direct further research endeavors to the most promising methodologies. Methods: The task of linking records can be viewed as a special form of object identification. We consider several non-stochastic methods and procedures for the record linkage task in addition to the Fellegi-Sunter model and perform an e…

Improving clustering of Web bot and human sessions by applying Principal Component Analysis

2019

View references (18) The paper addresses the problem of modeling Web sessions of bots and legitimate users (humans) as feature vectors for their use at the input of classification models. So far many different features to discriminate bots’ and humans’ navigational patterns have been considered in session models but very few studies were devoted to feature selection and dimensionality reduction in the context of bot detection. We propose applying Principal Component Analysis (PCA) to develop improved session models based on predictor variables being efficient discriminants of Web bots. The proposed models are used in session clustering, whose performance is evaluated in terms of the purity …

Functional connectivity inference from fMRI data using multivariate information measures

2022

Abstract Shannon’s entropy or an extension of Shannon’s entropy can be used to quantify information transmission between or among variables. Mutual information is the pair-wise information that captures nonlinear relationships between variables. It is more robust than linear correlation methods. Beyond mutual information, two generalizations are defined for multivariate distributions: interaction information or co-information and total correlation or multi-mutual information. In comparison to mutual information, interaction information and total correlation are underutilized and poorly studied in applied neuroscience research. Quantifying information flow between brain regions is not explic…

Post-task Effects on EEG Brain Activity Differ for Various Differential Learning and Contextual Interference Protocols

2017

A large body of research has shown superior learning rates in variable practice compared to repetitive practice. More specifically, this has been demonstrated in the contextual interference (CI) and in the differential learning (DL) approach that are both representatives of variable practice. Behavioral studies have indicate different learning processes in CI and DL. Aim of the present study was to examine immediate post-task effects on electroencephalographic (EEG) brain activation patterns after CI and DL protocols that reveal underlying neural processes at the early stage of motor consolidation. Additionally, we tested two DL protocols (gradual DL, chaotic DL) to examine the effect of di…

Intraparenchymal Brain Hemorrhage: "Birdlime" Effect Usefulness.

2018

The authors previously reported the novel transposition techniquefor microvascular decompression (MVD) using a tissue glue-coated collagen sponge (TachoSil Tissue Sealing Sheet; CSLBehring KK, Tokyo, Japan) soaked withfibrin glue (Tisseel 2-Component Fibrin Sealant, Vapor-Heated; Baxter Healthcare,Glendale, California, USA), termed the“birdlime”technique

Fast dendrogram-based OTU clustering using sequence embedding

2014

Biodiversity assessment is an important step in a metagenomic processing pipeline. The biodiversity of a microbial metagenome is often estimated by grouping its 16S rRNA reads into operational taxonomic units or OTUs. These metagenomic datasets are typically large and hence require effective yet accurate computational methods for processing.In this paper, we introduce a new hierarchical clustering method called CRiSPy-Embed which aims to produce high-quality clustering results at a low computational cost. We tackle two computational issues of the current OTU hierarchical clustering approach: (1) the compute-intensive sequence alignment operation for building the distance matrix and (2) the …