Search results for "minor"
showing 10 items of 877 documents
Ceļš: Latvijas Universitātes Teoloģijas fakultātes teoloģisks un kultūrvēsturisks izdevums, Nr. 59
2009
Finansiālais atbalstītājs - Ziemeļelbas Evaņģēliski luteriskajai baznīca (Vācija)
Observational data and orbits of the asteroids discovered at the Baldone Observatory in 2015–2018
2020
AbstractThis paper is devoted to the discovery of 37 asteroids at the Baldone Astrophysical Observatory (MPC 069) from 2015 to 2018, and one of dynamically interesting Mars-crosser (MC) observed at the Baldone Astrophysical Observatory, namely 2008 LX16. In Baldone Observatory, was independently discovered the Near-Earth Object 2018 GE3 on the image of 13 April 2018. Also, the NEO 2006 VB14 was observed doing its astrometry and photometry. Moreover, we observed asteroids 1986 DA and 2014 LJ1. We computed orbits and analyzed the orbital evolution of these asteroids. 566 positions and photometric observations of NEO objects 345705 (2006 VB14) and 6178 (1986 DA) were obtained with Baldone Schm…
Linking the Kinetic Energy Fraction and Equivalent Length Method for Trickle Irrigation Design under Local Losses
2020
New methods using analytical relationships to design drip irrigation laterals and subunits have been introduced in recent years based on the assumption that minor losses can be neglected. This assumption could be relaxed by applying the equivalent method, which makes it possible to account for minor losses, such as those caused by emitter connections, through formulas based on the rationale that an equivalent length of the drip lateral produces the same losses. However, equivalent length formulas are empirical; thus, they do not necessarily cover the entire range of conditions in the real-world contexts in which the formulas will be applied, and their extrapolation could lead to erroneous r…
Backlash against the procedural consensus
2020
While the politics of backlash is typically described as a reaction to policy decisions in favour of minority rights, immigration or globalisation, this essay focuses on the fact that backlash typically also involves a reaction against the procedural consensus liberal democracy is based upon. This challenge to democratic procedures and institutions may be even more dangerous in its effects than the substantial objectives of backlash. I use the composite definition of backlash suggested by Alter and Zürn to assess in how far the attacks on the institutions of liberal democracy have retrograde objectives in themselves or in how far they are merely instrumental to the pursuit of other retrogr…
Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Cha…
2021
Hematopoietic cell (HC) transplantation (HCT) is the last resort to cure hematopoietic malignancies that are refractory to standard therapies. Hematoablative treatment aims at wiping out tumor cells as completely as possible to avoid leukemia/lymphoma relapse. This treatment inevitably co-depletes cells of hematopoietic cell lineages, including differentiated cells that constitute the immune system. HCT reconstitutes hematopoiesis and thus, eventually, also antiviral effector cells. In cases of an unrelated donor, that is, in allogeneic HCT, HLA-matching is performed to minimize the risk of graft-versus-host reaction and disease (GvHR/D), but a mismatch in minor histocompatibility antigens …
Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation.
2016
Major histocompatibility complex class I polypeptide-related sequence A (MICA) is a highly polymorphic ligand of the activating NKG2D receptor on natural killer (NK) cells, γδ-T cells, and NKT cells. MICA incompatibilities have been associated with an increased graft-versus-host disease (GVHD) incidence, and the MICA-129 (met/val) dimorphism has been shown to influence NKG2D signaling in unrelated hematopoietic stem cell transplantation (uHSCT). We investigated the effect of MICA matching on survival after uHSCT. We sequenced 2172 patients and their respective donors for MICA. All patients and donors were high-resolution HLA-typed and matched for 10/10 (n = 1379), 9/10 (n = 636), or 8/10 (n…
CYP27A1, CYP24A1, and RXR-α Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study.
2018
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease resulting from a complex interaction of genetic and environmental factors. Hypovitaminosis D seems to contribute to MS susceptibility as both an environmental and a genetic risk factor. The aim of our study was to investigate the association of SNPs in CYP27A1, CYP24A1, and RXR- α genes, vitamin D status, and MS risk. We performed a nested case-control study on patients with multiple sclerosis and healthy controls. Serum 25(OH)D3 levels and genotyping of CYP27A1, CYP24A1, and RXR-α -SNPs were investigated both in MS patients and in healthy controls. Serum 25(OH)D3 levels were measured by a high-performance liquid chromatograp…
2020
Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has not been addressed yet. Therefore, we conducted an epigenome-wide analysis of DNA methylation on Lp(a) levels in two population-based studies (total n = 2208). We identified a CpG site in the LPA promoter which was significantly associated with Lp(a) concentrations. Surprisingly, the identified CpG site was found to overlap the SNP rs76735376. We genotyped this SNP de-novo in three studies (total n = 7512). The minor allele of rs76735376 (1.1% mi…
Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure
2021
Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10–25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study sought to identify a blood-based gene variant profile using accumulation of rare variants to promote precision medicine in fertility preservation programs. A case–control (n = 118, n = 32, respectively) WES study was performed in which only non-synonymous rare variants <
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
2017
International audience; We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68…