Search results for "mismatch"
showing 10 items of 345 documents
Infants' brain responses for speech sound changes in fast multifeature MMN paradigm.
2013
Abstract Objective We investigated whether newborn speech-sound discrimination can be studied in 40min using fast multifeature mismatch negativity (MMN) paradigm and do the results differ from those obtained with the traditional oddball paradigm. Methods Newborns' MMN responses to five types of changes (consonant identity, F0, intensity, vowel duration and vowel identity) were recorded in the multifeature group ( N =15) and vowel duration and vowel identity changes in the oddball group ( N =13), after which the MMNs from both groups were compared with each others. Results Statistically significant MMNs in the 190–600ms time range from the stimulus onset were found for most change types in b…
Audiovisual attention boosts letter-speech sound integration
2013
We studied attention effects on the integration of written and spoken syllables in fluent adult readers by using event-related brain potentials. Auditory consonant-vowel syllables, including consonant and frequency changes, were presented in synchrony with written syllables or their scrambled images. Participants responded to longer-duration auditory targets (auditory attention), longer-duration visual targets (visual attention), longer-duration auditory and visual targets (audiovisual attention), or counted backwards mentally. We found larger negative responses for spoken consonant changes when they were accompanied by written syllables than when they were accompanied by scrambled text. Th…
Newborn infants' auditory system is sensitive to Western music chord categories
2013
Neural encoding of abstract rules in the audition of newborn infants has been recently demonstrated in several studies using event-related potentials (ERPs). In the present study the neural encoding of Western music chords was investigated in newborn infants. Using ERPs, we examined whether the categorizations of major vs. minor and consonance vs. dissonance are present at the level of the change-related mismatch response (MMR). Using an oddball paradigm, root minor, dissonant and inverted major chords were presented in a context of consonant root major chords. The chords were transposed to several different frequency levels, so that the deviant chords did not include a physically deviant f…
Photovoltaic electricity scenario analysis in urban contests: an Italian case study
2012
Abstract This paper shows a methodology for the assessment of the photovoltaic potential in urban areas using Google Earth™ tool that provides either satellite images of the roofs of buildings or their number of floors by means of the Street View function. The applicability of the methodology has been tested on a selected urban area of the city of Palermo in the South of Italy. After classifying roofs according to the shape, orientation and pitch of buildings with different morphologies, the share of energy generated by the installable PV systems was evaluated with regard to the number of floors. Moreover the coverage of the electricity demand was investigated on the basis of the consumptio…
Hilbert-Huang versus Morlet wavelet transformation on mismatch negativity of children in uninterrupted sound paradigm
2008
Background Compared to the waveform or spectrum analysis of event-related potentials (ERPs), time-frequency representation (TFR) has the advantage of revealing the ERPs time and frequency domain information simultaneously. As the human brain could be modeled as a complicated nonlinear system, it is interesting from the view of psychological knowledge to study the performance of the nonlinear and linear time-frequency representation methods for ERP research. In this study Hilbert-Huang transformation (HHT) and Morlet wavelet transformation (MWT) were performed on mismatch negativity (MMN) of children. Participants were 102 children aged 8–16 years. MMN was elicited in a passive oddball parad…
Automated Synthesis of Application-layer Connectors from Automata-based Specifications
2019
Abstract Ubiquitous and Pervasive Computing, and the Internet of Things, promote dynamic interaction among heterogeneous systems. To achieve this vision, interoperability among heterogeneous systems represents a key enabler, and mediators are often built to solve protocol mismatches. Many approaches propose the synthesis of mediators. Unfortunately, a rigorous characterization of the concept of interoperability is still lacking, hence making hard to assess their applicability and soundness. In this paper, we provide a framework for the synthesis of mediators that allows us to: (i) characterize the conditions for the mediator existence and correctness; and (ii) establish the applicability bo…
Una tipología de desajustes entre competencias y educación utilizando un análisis comparativo entre países
2015
This paper aims to discuss the value of the diplomas and the situation of downgrading on the labour market. Its novelty is to compare skills both acquired and required in employment, using a self - assessment carried out by young higher education graduates a cross nine countries of Europe, Japan and Canada. More precisely, we illustrate the incidences of diploma and skill mismatches using three higher education graduate surveys, two international surveys (CHEERS, REFLEX) and a Canadian survey (NGS). We define possible over - education and skill mismatches and then present an empirical typology to show the most frequent cases of mismatches. The ideal situation which corresponds to a perfect …
Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence
2020
AbstractTranscriptional regulation of DNA repair is of outmost importance for the restoration of DNA integrity upon genotoxic stress. Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch repair (MMR) genes (MSH2, MSH6, EXO1) and of RAD51, the central homologous recombination repair (HR) component, ultimately leading to downregulation of MMR and HR. B[a]P-induced gene repression is caused by abrogated E2F1 signalling. This occurs through proteasomal degradation of E2F1 in G2-arrested cells and downregulation of E2F1 mRNA expression in G1-arrested cells. Repression of E2F1-me…
Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents
2000
Mammalian mismatch repair has been implicated in mismatch correction, the prevention of mutagenesis and cancer, and the induction of genotoxicity and apoptosis. Here, we show that treatment of cells specifically with agents inducing O(6)-methylguanine in DNA, such as N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea, elevates the level of MSH2 and MSH6 and increases GT mismatch binding activity in the nucleus. This inducible response occurs immediately after alkylation, is long-lasting and dose-dependent, and results from translocation of the preformed MutSalpha complex (composed of MSH2 and MSH6) from the cytoplasm into the nucleus. It is not caused by an increase in MSH2 gen…
Alterations of DNA Repair in Melanoma Cell Lines Resistant to Cisplatin, Fotemustine, or Etoposide
2000
Resistance to chemotherapy is a common phenomenon in malignant melanoma. In order to assess the role of altered DNA repair in chemoresistant melanoma, we investigated different DNA repair pathways in one parental human melanoma line (MeWo) and in sublines of MeWo selected in vitro for drug resistance against four commonly used drugs (cisplatin, fotemustine, etoposide, and vindesine). Host cell reactivation assays with the plasmid pRSVcat were used to assess processing of different DNA lesions. With ultraviolet-irradiated plasmids, no significant differences were found, indicating a normal (nucleotide excision) repair of DNA photoproducts. With singlet oxygen-treated plasmid, the fotemustine…