Search results for "mito"
showing 10 items of 2513 documents
Optical quality of hyperopic and myopic phakic intraocular lenses
2013
Aims: To assess and compare the optical quality of the myopic and hyperopic implantable collamer lens (ICL) from its wavefront aberrations for different powers and pupil diameters. Settings and Design: Prospective study. Material and Methods: The wavefront aberrations of two myopic (−3 and −6 diopters (D)) and two hyperopic V4b ICLs (+3 and +6D) were measured in vitro . To assess and compare the optical quality of different powers of ICLs, we analyzed the root mean square (RMS) of total higher order aberrations (HOAs), trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration at 3- and 4.5-mm pupil. In addition, the point spread functions (PSFs) of each ICL evaluated were ca…
Valutazione del potenziale anticancro del frutto di Mangifera indica proveniente dalle aree rurali siciliane
2022
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and Cilia to Regulate Ciliogenesis and Ciliary Protein Traffic
2021
ABSTRACTELMODs are a family of three mammalian paralogs that display GTPase activating protein (GAP) activity towards a uniquely broad array of ADP-ribosylation factor (ARF) family GTPases that includes ARF-like (ARL) proteins. ELMODs are ubiquitously expressed in mammalian tissues, highly conserved across eukaryotes, and ancient in origin, being present in the last eukaryotic common ancestor. We described functions of ELMOD2 in immortalized mouse embryonic fibroblasts (MEFs) in the regulation of cell division, microtubules, ciliogenesis, and mitochondrial fusion. Here, using similar strategies with the paralogs ELMOD1 and ELMOD3, we identify novel functions and locations of these cell regu…
Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B
2020
Abstract The TRM10 family of methyltransferases is responsible for the N1-methylation of purines at position 9 of tRNAs in Archaea and Eukarya. The human genome encodes three TRM10-type enzymes, of which only the mitochondrial TRMT10C was previously characterized in detail, whereas the functional significance of the two presumably nuclear enzymes TRMT10A and TRMT10B remained unexplained. Here we show that TRMT10A is m1G9-specific and methylates a subset of nuclear-encoded tRNAs, whilst TRMT10B is the first m1A9-specific tRNA methyltransferase found in eukaryotes and is responsible for the modification of a single nuclear-encoded tRNA. Furthermore, we show that the lack of G9 methylation cau…
Kuuluuko koululle kummia? : Vallilan ala-asteen ja Suomen Kansallisteatterin kummikouluyhteistyö lukuvuonna 1999-2000
2001
Alumnos con NNEE : la alta capacidad intelectual
2013
El siguiente trabajo de investigación, es una propuesta realizada por un alumno de 4º año de Magisterio de la Universidad de Valencia. La propuesta forma parte del TFG (Trabajo de Fin de Grado) del Grado de Maestro en Educación Primaria. A través de la investigación, se pretende demostrar que el hecho de recibir algún tipo de atención diferenciada, tomando las medidas adecuadas a su capacidad intelectual, tiene repercusiones positivas sobre el alumnado. En este caso en particular, se analizará si los alumnos con un diagnóstico en A.C. (Altas Capacidades) se ven beneficiados tanto a nivel emocional como académico, cuando se pone en práctica una buena medida escolar. The following research wo…
Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits
2021
AbstractEarly-life environment is known to affect later-life health and disease, which could be mediated by the early-life programming of telomere length, a key hallmark of ageing. According to thefetal programming of telomere biology hypothesis, variation in prenatal exposure to hormones is likely to influence telomere length. Yet the contribution of key metabolic hormones,i.e. thyroid hormones (THs), has been largely ignored. We recently showed that in contrast to predictions, exposure to elevated prenatal THs increased postnatal telomere length in wild collared flycatchers, but the generality of such effect, its underlying proximate mechanisms and consequences on survival have not been i…
La cuginanza. Storie esemplari di cugini dai Greci a Paperino
2022
Il saggio indaga in una prospettiva storico-linguistica e antropologica la natura del rapporto di cuginanza nella civiltà greca, proponendo confronti con la terminologia e la relativa concezione nel mondo latino. Al centro dell'indagine, condotta principalmente per un pubblico di non specialisti, c'è un ragionamento sulle occorrenze più antiche del termine greco "anepsiòs", esaminate nel loro contesto specifico all'interno, soprattutto, dei poemi omerici. Emerge la particolare natura del rapporto di cuginanza (termine attestato in greco nella forma anepsiòtes) secondo i Greci, che ne fa, specie nel caso di cugini primi, una fattispecie di parenti legati da uno stretto reciproco legame che i…
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
2014
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…
Historia del Pensamiento Político Premoderno 03 Platón
2010
Tema 3 El pensamiento político de Platón 1. Platón 2. ¿Cuál es el contexto político e intelectual en el que vivirá Platón? Las guerras del Peloponeso. Platón y la dictadura de los Treinta Tiranos. Sócrates, el único político autentico de Atenas. La experiencia con el joven Dionisio de Siracusa. 3. Platón crea la Academia. Regreso a Siracusa. La Academia, centro de conocimiento. 4. El Mito de la caverna. 5. Justicia, estado y política: el rey-filósofo. 6. Ciudadanos, sofistas y Sócrates. 7. Teoría política de Platón: el Estado Ideal. 8. Teoría de la educación en Platón. 9. La República, obra de madurez de Platón. 10. Formas políticas de gobierno: Aristocracia. Timocracia. Oligarquía. Democra…