Search results for "mito"

Secondary Worlds

2010

Randomized Trial : D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans

2021

Background: Based on earlier studies, natural metabolite D-glyceric acid (DGA) does not seem to play any role in whole-body metabolism. Nevertheless, one ethanol oxidation-related rat study with controversial results raised our interest. According to preparatory studies for the regulatory approval of DGA, some highly conserved mechanism seems to subtly activate the cellular energy metabolism. Therefore, the present 25-days double-blind human study with placebo control was initiated. Purpose: The main target in the present study with 27 healthy 50–60-year-old human volunteers was to find out whether an “acute” 4-days and a longer 21-days exogenous DGA regimen caused moderate activation of th…

Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid

2022

It has been shown that small doses of oral D-glyceric acid (DGA) activate mitochondrial metabolism and reduce inflammation among 50–60-year-old healthy volunteers. The present results with the same small doses reveal that after a 4-day DGA regimen, a dose of DGA activated the HO-1 pathway acutely, while enhanced inflammatory status after the 4-day DGA regimen seemed to be able to downregulate the HO-1 pathway in non-acute measurement. Blood bilirubin was strongly upregulated towards the end of the altogether 21-day study period with positive associations towards improved inflammation and reduced blood triglycerides. After the 4-day DGA regimen, hepatic inflow of blood bilirubin with albumin…

Mecanismo molecular del proceso de ubicuitinación mediado por el complejo laforina-malina.

2017

Tesis doctoral, 123 páginas.

Real-world experience with obeticholic acid in patients with primary biliary cholangitis

2021

Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…

Prof. P. Šmita zinātniskās darbības 30 gadi

1928

Valodnieka, tulkotāja Ernesta Bleses rakstā aplūkots prof. P. Šmita dzīves gājums, studijas, darbība Tālajos austrumos, Latvijā, sadarbība ar periodiskajiem izdevumiem ("Mājas Viesa Mēnešraksts", "Druva", RLB Zinību komisijas rakstu krājumi u.c.), publicējot tajos tulkojumus, ceļojumu piezīmes, polemiku valodniecības jautājumos, recenzijas par "Latvu Dainu" burtnīcām, Glika bībeles valodu. Aplūkoti arī P. Šmita publicētie darbi etnogrāfijā, folklorā u.c. Autors norāda, ka P. Šmits viens no pirmajiem mūsu folkloras pētniecību nostādījis uz zinātniskajiem pamatiem. E. Bleses raksts publicēts mēnešrakstā "Latvju Grāmata", 1928, Nr. 3, 145.-148. lpp.; Nr. 4, 209.-217. lpp. Autors iesaka vēl pub…

Profesors Pēteris Šmits : Pēc autobiogrāfiskiem materiāliem sarakstījis G. Šaurums

1940

Biogrāfiskajā izklāstā iespējams iepazīties ar P. Šmita bērnības iespaidiem ģimenē, skolas gaitām, mācībām ģimnāzijā, Maskavas un Pēterburgas universitātēs. Tekstā minētas ļoti daudz personības, kuras atstājušas zināmu ietekmi uz P. Šmitu - tie ir gan latviešu, gan cittautu rakstnieki, filozofi, sabiedriskie, kultūras darbinieki, mācībspēki, kā arī P. Šmita ceļojums uz Ķīnu, pavadīto laiku Vladivostokā, atgriešanos Latvijā 1920. gadā, darbību Latvijas Universitātē. Sniegts arī īss ieskats P. Šmita ģimenes dzīvē.

The complete mitochondrial genome of the wood tiger moth (Arctia plantaginis) and phylogenetic analyses within Arctiinae

2021

We report the assembly and annotation of the complete mitochondrial genome of the warningly-coloured wood tiger moth (Arctia plantaginis) and investigate its phylogenetic position within Arctiinae. The A.plantaginis mitogenome is 15,479 bp long with 13 protein-coding genes, 22 transfer RNAs, 2 ribosomal RNA genes, and an A + T-rich region (D-loop). The phylogenetic analyses based on 13 protein-coding genes showed A.plantaginis clustering within a clade of species with white wings and yellow or red bodies. This result can be useful in understanding the evolution of coloration in Arctiid moths. Peer reviewed

Virus-cell interactions as a pathological mechanism of parvovirus infection

2014

In-Depth Characterization of Bioactive Extracts from Posidonia oceanica Waste Biomass

2019

© 2019 by the authors.