Search results for "mixture"

Differential effects of calcium channel antagonists (omega-conotoxin GVIA, nifedipine, verapamil) on the electrically-evoked release of [3H]acetylcho…

1990

Electrically-evoked release of [3H]acetylcholine from autonomic neurons (myenteric plexus), motoneurons (phrenic nerve) and the central nervous system (neocortex) was investigated in the presence and absence of the calcium channel antagonists omega-conotoxin GVIA, nifedipine and verapamil, whereby the same species (rat) was used in all experiments. Release of [3H]acetylcholine was measured after incubation of the tissue with [3H]choline. omega-Conotoxin GVIA markedly reduced (70%) the evoked release of [3H]acetylcholine from the myenteric plexus of the small intestine (IC50: 0.7 nmol/l) with a similar potency at 3 and 10 Hz stimulation. An increase in the extracellular calcium concentration…

Perinatal xenohormone exposure impacts sweet preference and submandibular development in male rats.

2013

Objective To determine the effect of perinatal exposure to low doses of genistein and/or vinclozolin on submandibular salivary gland (SSG) development in juvenile and adult male rats and to establish a link with sweet preference. Material and Methods Female rats received orally (1 mg kg−1 body weight/day) genistein and vinclozolin, alone or in combination, from the first gestational day up to weaning. Sweet preference was assessed at weaning and in adulthood in male offspring; submandibular glands were then collected to study the morphogenesis and mRNA expression of steroid receptors, growth factors and taste related proteins. Results Exposure to genistein and/or vinclozolin resulted in a h…

Second-hand smoke exposure in 4-year-old children in Spain: Sources, associated factors and urinary cotinine

2016

Introduction Second-hand smoke exposure (SHS) in children remains as a major pollution problem, with important consequences for children's health. This study aimed to identify the sources of exposure to SHS among 4-year-old children, comparing self-reports to a urinary biomarker of exposure, and characterize the most important variables related to SHS exposure in this population. Methods 4-year-old children's exposure to SHS was assessed by a parental-reported questionnaire and by urinary cotinine (UC) measurements in 1757 participants from 4 different areas of the Spanish INMA (INfancia y Medio Ambiente – Environment and Childhood) Project. The questionnaire about SHS included information …

Inhibition of mechanical activity by neurotensin in rat proximal colon: involvement of nitric oxide.

1997

The aim of the present study was to define the nature of inhibitory action of neurotensin in rat proximal colon. Mechanical activity was detected as changes of intraluminal pressure. Neurotensin (10(-10) to 10(-7) M), in the presence of atropine (10(-6) M), guanethidine (10(-6) M), and nifedipine (10(-8) M), induced a tetrodotoxin-insensitive inhibitory effect characterized by the complete disappearance of the spontaneous phasic contractions. The inhibitory effect of neurotensin (10(-7) M) was abolished by scorpion venom (Leiurus quinquestriatus hebraeus) (10(-6) g/ml) or high K+ (40 mM KCl), whereas it persisted in the presence of omega-conotoxin GVIA, (10(-7) M). N omega-nitro-L-arginine…

VISMapper

2018

Ultra-fast exhaustive cartography of viral insertion sites for gene therapy.

Characterization of rubberized asphalt for railway sub-ballast. Improvements in the mix-design, performance features and rational methodology of HMA_…

2018

(STR) can be incorporated into asphalt mixtures in two different methods, which are referred to as the wet-dry process. The blending of recycled rubber (CRM) with asphalt has been used for years, and several manufacturing processes have been developed in Europe as well as in the USA. The use of a bituminous sub-ballast layer has been pointed out as an exciting alternative to the granular sub-ballast design traditionally applied in most railroad tracks. Frequently, unbound granular materials are replaced by bituminous sub-ballast that provide additional benefits to the subgrade protection. Much research has been conducted on finding other alternative material to be used as a modifier in asph…

CHARACTERIZATION OF RUBBERIZED ASPHALT FOR RAILWAY SUB-BALLASTS

Tesi di dottorato sotto la supervisione del professore Gaetano di Mino del Dipartimento di Ingegneria Civile di Palermo), come borsista Marie-Curie all'interno del progetto SUPRITN 2013/2017. Il mio lavoro e la linea della ricerca riguarda i conglomerati bituminosi con granulato di gomma per lo strato di sub-ballast nelle linee ferroviarie. L’attività di ricerca comprende il mix-design dell’asfalto con aggiunta di gomma, la caratterizzazione e le prestazioni per la ferrovia in termini di comportamento meccanico e lo smorzamento delle vibrazioni. In particolare con l’avvento dell’alta velocità, diversi studi hanno evidenziato ottime caratteristiche fisico-meccaniche per ciò che riguarda il c…

Perception of mixtures of odorants and tastants: sensory and analytical points of view

2017

Perception of mixtures of odorants and tastants: sensory and analytical points of view

Thermo-oxidative stabilization of poly(lactic acid)-based nanocomposites through the incorporation of clay with in-built antioxidant activity

2017

In this work, an innovative approach to overcome the issue of the poor thermo-oxidative stability of polymer/clay nanocomposites is proposed. Specifically, biodegradable poly(lactic acid) (PLA)-based nanocomposites, containing organo-modified clay with in-built antioxidant activity, were prepared. Through a two-step chemical protocol, a hindered phenol antioxidant was chemically linked to the ammonium quaternary salt which was then intercalated between the clay platelets [(AO)OM-Mt]. The nanocomposites were characterized and their thermo-oxidative stability during melt processing and under long-term thermal test conditions was investigated. PLA nanocomposites containing the (AO)OM-Mt showed…

Zn(II) and Ni(II) complexes with poly-histidyl peptides derived from a snake venom

2018

Abstract The snake venoms are complex mixtures containing many bioactive peptides and proteins; some of them are aimed to protect the snake glands, where the venom is stored, until the latter is inoculated in the victim. In the venom of some vipers of the genus Atheris , a set of peptides containing poly-His and poly-Gly segments was recently found. Poly-His peptides are not rare in Nature. Although their exact biological function is most often unknown, one thing is certain: they have good binding properties towards the transition metal ions. As a matter of fact, the imidazole side chain of histidine is one of the groups most frequently involved in metal complexation in the active sites of …