Search results for "mixture"

Immobilization of murine noroviruses in a cultivated phaeozem soil and its reversibility

2017

Immobilization of murine noroviruses in a cultivated phaeozem soil and its reversibility. Environmental Microbiology & Microbial Ecology

Eradication of Plasmodiophora brassicae during composting of wastes

2006

Survival of infectious inoculum of the clubroot pathogen Plasmodiophora brassicae was assessed following bench-scale flask composting experiments and large-scale composting procedures. Clubroot-affected material was provided by artificial inoculation of Chinese cabbage or naturally infected Brussels sprout and cabbage roots. Both sets of diseased material were used in flask experiments, and the latter in large-scale windrow and aerated tunnel experiments. Municipal green wastes, onion waste and spent mushroom compost were evaluated in flask experiments with varying temperature, aeration and moisture conditions. Green wastes were used in larger-scale composts. Within the limits of a Chinese …

Multitemporal Unmixing of Medium-Spatial-Resolution Satellite Images: A Case Study Using MERIS Images for Land-Cover Mapping

2011

Data from current medium-spatial-resolution imaging spectroradiometers are used for land-cover mapping and land-cover change detection at regional to global scales. However, few landscapes are homogeneous at these scales, and this creates the so-called mixed-pixel problem. In this context, this study explores the use of the linear spectral mixture model to extract subpixel land-cover composition from medium-spatial-resolution data. In particular, a time series of MEdium Resolution Imaging Spectrometer (MERIS) full-resolution (FR; pixel size of 300 m) images acquired over The Netherlands is used to illustrate this study. The Netherlands was selected because of the following: 1) the fragmenta…

Racemization of Secondary-Amine-Containing Natural Products Using Heterogeneous Metal Catalysts

2018

Aerobic composting and anaerobic digestion of pulp and paper mill sludges

1997

The feasibility of aerobic vessel composting and anaerobic digestion for the treatment of pulp and paper mill sludges were studied. The composting studies made use of primary and secondary sludge from a de-inking and paper mill. In six parallely aerated 500 1 vessels with various carbon : nitrogen (C:N) -ratios, the most optimal performance was obtained with C:N -ratios of c. 22–35, while higher and lower ratios delayed the temperature increase. With the optimal ratios, the thermophilic stage was reached within 36 h, and the stage lasted for about seven days. In the scale-up study (18 m3 compost vessel), the thermophilic stage was reached within 24 h. An effective dehydratation of the mass …

Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine

2020

Coxsackievirus B (CVB) enteroviruses are common pathogens that can cause acute and chronic myocarditis, dilated cardiomyopathy, aseptic meningitis, and they are hypothesized to be a causal factor in type 1 diabetes. The licensed enterovirus vaccines and those currently in clinical development are traditional inactivated or live attenuated vaccines. Even though these vaccines work well in the prevention of enterovirus diseases, new vaccine technologies, like virus-like particles (VLPs), can offer important advantages in the manufacturing and epitope engineering. We have previously produced VLPs for CVB3 and CVB1 in insect cells. Here, we describe the production of CVB3-VLPs with enhanced pro…

Differential memory persistence of odor mixture and components in newborn rabbits: competition between the whole and its parts

2014

Interacting with the mother during the daily nursing, newborn rabbits experience her body odour cues. In particular, the mammary pheromone (MP) contained in rabbit milk triggers the typical behaviour which helps to localize and seize the nipples. It also promotes the very rapid appetitive learning of simple or complex stimuli (odorants or mixtures) through associative conditioning. We previously showed that 24h after MP-induced conditioning to odorants A (ethyl isobutyrate) or B (ethyl maltol), newborn rabbits perceive the AB mixture in a weak configural way, i.e. they perceive the odour of the AB configuration in addition to the odours of the elements. Moreover, after conditioning to the m…

Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design

2013

Heat shock protein 60 kDa (Hsp60) is a chaperone classically believed to be involved in assisting the correct folding of other mitochondrial proteins. Hsp60 also plays a role in cytoprotection against cell stressors, displaying for example, antiapoptotic potential. Despite the plethora of studies devoted to the mechanism of Hsp60's function, especially in prokaryotes, fundamental issues still remain unexplored, including the definition of its role in cancer. Key questions still unanswered pertain to the differences in structure-function features that might exist between the well-studied prokaryotic GroEL and the largely unexplored eukaryotic Hsp60 proteins. In this article we discuss these …

Keyhole Limpet Haemocyanin in Experimental Bladder Cancer

2000

Objectives: Keyhole limpet haemocyanin (KLH) is a high-molecular-weight protein antigen collected from the haemolymph of the sea mollusk Megathura crenulata. It i

Chaperonopathies and chaperonotherapy. Hsp60 as therapeutic target in cancer: potential benefits and risks.

2013

In this minireview we focus on Hsp60 as a target for anticancer therapy. We discuss the new concepts of chaperonopathies and chaperonotherapy and present information on Hsp60 localization in the cell membrane of human tumor cells. We describe novel mechanisms for Hsp60 reaching the extracellular environment that involve membrane-associated stages, as well as data on anti-Hsp60 antibodies found in human sera, both in normal subjects and patients affected by autoimmune diseases. Finally, we discuss possible therapeutic applications of anti-Hsp60 antibodies in cancer treatment, evaluating also side effects on non-tumor cells. In conclusion, the way for investigating Hsp60-targeted anti-tumor t…