Search results for "moda"
showing 10 items of 1753 documents
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson’s Disease
2021
Background: Movement execution is impaired in patients with Parkinson’s disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson’s disease patients remains largely unexplored. Objective: We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing. Methods: Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recor…
"I just saw someone die omfg" : multimodal representations of the shooting of Michael Brown on Tumblr
2015
Tämän tutkielman aiheena on tutkia suosiotaan kasvattavan sosiaalisen median sivuston Tumblrin rakentamia representaatioita postauksissa, jotka jatkuvasti käsittelivät tavalla tai toisella Yhdysvalloissa, Fergusonin kaupungissa elokuussa 2014 tapahtunutta poliisin ja tummaihoisen nuoren miehen, Michael Brownin, välistä yhteenottoa jossa Brown sai surmansa. Ampumatapaus ja sitä seuranneet mielenosoitukset saivat huomiota sekä perinteisessä että sosiaalisessa mediassa. Tutkielmani tarkoitus on selvittää kuinka kyseiseen ampumatapaukseen liittyvissä postauksissa Tumblrissa tapausta representoitiin, eli millaisia merkityksiä siitä rakennettiin multimodaalisin eli monikanavaisin keinoin. Aineist…
Regular versus as-needed budesonide and formoterol combination treatment for moderate asthma: A non-inferiority, randomised, double-blind clinical tr…
2015
Summary Background Treatment guidelines for patients with moderate persistent asthma recommend regular therapy with a combination of an inhaled corticosteroid and a longacting β 2 agonist plus as-needed rapid-acting bronchodilators. We investigated whether symptom-driven budesonide and formoterol combination therapy administered as needed would be as effective as regular treatment with this combination plus as-needed symptom-driven terbutaline for patients with moderate asthma. Methods In this non-inferiority randomised clinical trial, we recruited adult patients (18–65 years of age) with stable moderate persistent asthma, according to 2006 Global Initiative for Asthma guidelines. Patients …
Changes in 18F-FDG tumor metabolism after a first course of neoadjuvant chemotherapy in breast cancer: influence of tumor subtypes
2012
BACKGROUND The aim of this study is to evaluate the impact of the different breast cancer subtypes on the tumor (18)F-FDG uptake at baseline and on its changes after the first course of neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS One hundred and fifteen women with newly diagnosed, large or locally advanced breast cancer undergoing NAC were included. Estrogen receptor (ER), progesterone receptor (PR) and HER2 status were used to define three major tumor subtypes: triple negative (TN) (ER-/PR-/HER2-), luminal (ER+ and/or PR+; HER2-) and HER2 positive (HER2+). Using Fluorine-18 fluorodeoxyglucose positron emission tomography, the tumoral standard uptake value (SUV) maximal index was m…
ČUKSTOŠĀS GALERIJAS MODU MIKROREZONATORU DISPERSIJAS OPTIMIZĒŠANA KERRA FREKVENČU ĶEMMES ĢENERĒŠANAI VIENA SOLITONA REŽĪMĀ
2021
Viens no galvenajiem čukstošās galerijas modu mikrorezonatoru pielietojumiem ir frekvenču ķemmes ģenerēšana, kur monohromatiska lāzera signāls tiek pārkonvertēts vairākās frekvencēs ar regulāru intervālu starp tām. Priekš pielietojuma telekomunikācijās pie ierosinošā lāzera viļņa garuma 1550 nm frekvenču intervālam starp modām vajag būt ap 100 GHz. Lai panāktu frekvenču ķemmes ģenerāciju pie šādiem nosacījumiem, ir nepieciešams optimizēt rezonatora ģeometriju, lai tā raksturīgā dispersija ir līdzsvarā ar Kerra nelinearitāti. Darba mērķis ir izveidot tādu rezonatora ģeometriju, lai pie ierosinošā lāzera viļņa garuma 1550 nm rezonators darbotos viena solitona režīmā. Darbā tika atrasts, ka op…
Uz čukstošās galerijas modu mikrorezonatoru bāzes veidotu sensoru modelēšana
2019
Darbā tiek pētīti uz čukstošās galerijas modu mikrorezonatoru bāzes veidoti sensori. Tiek veiktas datorsimulācijas ar programmu COMSOL Multiphysics. Datorsimulācijās tiek modelēti dažāda izmēra temperatūras sensori, kas atsevišķos gadījumos tiek salīdzināts ar eksperimentu. Vēl tiek modelēts sensors bio-slāņa biezuma noteikšanai, kas aplīp ap mikrorezonatoru. Kā arī sensors vienas molekulas noteikšanai.
Čukstošās galerijas modu mikrorezonatoru modelēšana
2018
Dotajā darbā tiek aprakstīta teorija un modelēšanas rezultāti par gaismas izplatīšanos sfēriskos Čukstošās galerijas modu optiskajos mikrorezonatoros ar diametru 1 - 5 um. Modelēšanai tiek izmantota COMSOL Multiphysics datorprogramma ar viļņu optikas moduli (Wave Optics Module). Tiek apskatītas sistēmas prizma-rezonators un optiskā šķiedra-rezonators. Kā galvenie kontroles parametri tiek izmantotas elektriskā lauka Ez komponentes kartes un laikā vidējotā enerģijas blīvuma vērtība rezonatorā. 2D vidē tiek modelēts gaistošās gaismas lauks, rezonatorā esošā starojuma atkarība no gaismas krišanas leņķa prizmā, šķiedras platuma, rezonatora attāluma līdz prizmai/šķiedrai, rezonatora izmēra un krī…
LA CALUNNIA DIFENSIVA AI CONFINI DEL DIRITTO DI DIFESA: SULLA NECESSITÀ DI DISTINGUERE TRA CALUNNIA IMPLICITA E CALUNNIA-MEZZO
2020
La giurisprudenza sembra avere ormai individuato un criterio sufficientemente stabile per decidere quando la calunnia difensiva sia lecita e quando non lo sia: a tal fine, occorrerebbe verificare che tra calunnia e difesa corra (quella che i giudici chiamano) una stretta connessione funzionale; la quale, peraltro, dipenderebbe anche dalle modalità concrete della calunnia: quanto più dettagliata e credibile sia questa, tanto meno stretta sarebbe la sua connessione funzionale con la difesa. Nell’articolo si sostiene che, sebbene le soluzioni giurisprudenziali alle quali si giunge in applicazione di questo criterio appaiano generalmente condivisibili, il criterio stesso ne costituisce una gius…
Challenges and new prospects in hepatosplenic γδ T-cell lymphoma.
2014
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid neoplasms characterized by aggressive clinical behavior and dismal prognosis. Hepatosplenic γδ T-cell lymphoma (γδ-HSTL) is a particular form of PTCL that arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. γδ-HSTL has a rapidly progressive course and poor outcome due also to its refractoriness to conventional chemotherapy regimens. The very low incidence of γδ-HSTL, along with its propensity to mimic different pathological entities, makes this lymphoma a true diagnostic challenge. In this review, we highlight the biological and clinical features of γδ-HSTL that contribute to making this lymphoma…
Underuse of long-term routine hospital follow-up care in patients with a history of breast cancer?
2011
Abstract Background After primary treatment for breast cancer, patients are recommended to use hospital follow-up care routinely. Long-term data on the utilization of this follow-up care are relatively rare. Methods Information regarding the utilization of routine hospital follow-up care was retrieved from hospital documents of 662 patients treated for breast cancer. Utilization of hospital follow-up care was defined as the use of follow-up care according to the guidelines in that period of time. Determinants of hospital follow up care were evaluated with multivariate analysis by generalized estimating equations (GEE). Results The median follow-up time was 9.0 (0.3-18.1) years. At fifth and…