Search results for "model."
showing 10 items of 23664 documents
A Multi-Objective Design Approach for the c Chart Considering Taguchi Loss Function
2014
The present paper proposes a multi-objective design approach for the c chart, considering in the optimization process of the chart parameters both the statistical and the economic objectives. In particular, the minimization of the hourly total quality related costs is the considered objective to carry out the economic goal, whereas the statistical objective is reached by the minimization the out-of-control average run length of the chart. A mixed integer non-linear constrained mathematical model is formulated to solve the treated multi-objective optimization problem, whereas the Pareto optimal frontier is described by the «-constraint method. In order to show the employment of the proposed …
CALIBRATION OF LÉVY PROCESSES USING OPTIMAL CONTROL OF KOLMOGOROV EQUATIONS WITH PERIODIC BOUNDARY CONDITIONS
2018
We present an optimal control approach to the problem of model calibration for L\'evy processes based on a non parametric estimation procedure. The calibration problem is of considerable interest in mathematical finance and beyond. Calibration of L\'evy processes is particularly challenging as the jump distribution is given by an arbitrary L\'evy measure, which form a infinite dimensional space. In this work, we follow an approach which is related to the maximum likelihood theory of sieves. The sampling of the L\'evy process is modelled as independent observations of the stochastic process at some terminal time $T$. We use a generic spline discretization of the L\'evy jump measure and selec…
Wiener-Granger Causality in Network Physiology with Applications to Cardiovascular Control and Neuroscience
2016
Since the operative definition given by C. W. J. Granger of an idea expressed by N. Wiener, the Wiener–Granger causality (WGC) has been one of the most relevant concepts exploited by modern time series analysis. Indeed, in networks formed by multiple components, working according to the notion of segregation and interacting with each other according to the principle of integration, inferring causality has opened a window on the effective connectivity of the network and has linked experimental evidences to functions and mechanisms. This tutorial reviews predictability improvement, information-based and frequency domain methods for inferring WGC among physiological processes from multivariate…
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in…
2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main factors sustaining PDAC progression, the alteration of cell metabolism has emerged to have a key role in PDAC cell proliferation, invasion, and resistance to standard chemotherapeutic agents. Taking into account all these factors and the urgency in evaluating novel options to treat PDAC, in the present work we reported the synthesis of a new series of indolyl-7-azaindolyl triazine compounds inspired by marine bis-indolyl alkaloids. We first assessed the ability of the new triazine compounds to inhibit the enzymatic activity of pyruvate de…
Digitālās aparatūras projektēšanas un testēšanas tiešsaistes platforma
2022
Darba mērķis ir izstrādāt un analizēt tiešsaistes platformu digitālās aparatūras attīstītājrīku attālinātai pārvaldībai, programmaparatūras glabāšanai un šīs programmaparatūras attālinātai testēšanai platformā pieejamos attīstītājrīkos. Darbā tiek izstrādāta platforma, veikta platformas darbības mehānismu modelēšana, ap rakstīti sarežģījumi šādas platformas izstrādē, izstrādes laikā izmantotie risinājumi un to arhi tektūra. Precīzāk, tiek izstrādāta un aprakstīta vāja reāllaika attālinātas mijiedarbības realizācija starp platformas lietotājiem un digitālo aparatūru, tai skaitā attālināta aparatūras programmēša na, attālināta testēšana un attālināta izmantošana. Tiek aprakstītas, analizētas …
Elektroniskās datu bāzes "Vilis Plūdons" izstrāde
2018
. Bibliotēkas nodarbojas ar sava novada kultūras mantojuma saglabāšanu, kā arī tā pieejamības nodrošināšanu, tāpēc tiek veidotas novadpētniecības datubāzes. Pētījuma mērķis ir izveidot elektroniskās datubāzes “Vilis Plūdons” modeli. To paredzēts izstrādāt Bauskas Centrālajai bibliotēkai. Pētījuma gaitā veikta piecu publisko bibliotēku novadpētniecības datubāzu un materiālu par Vili Plūdoni kontentanalīze, kā arī intervijas ar bibliotēkas darbiniekiem un V. Plūdoņa muzeja vadītāju. Pētījuma rezultātā apzināts krājums, ko iekļaut datubāzē un noskaidrots, ka nepieciešams veidot bibliogrāfisku datubāzi. Tika izstrādāts modelis, kurā aprakstīts, kā veidot bibliogrāfiskos ierakstus un kā padarīt …
Model społeczeństwa a założenia Specjalnej Strefy Demograficznej
2016
Założenia opolskiej Specjalnej Strefy Demograficznej odwołują się do strukturalno-systemowych teorii społeczeństwa. Stan katastrofy demograficznej wymaga, moim zdaniem, przeprowadzenia reprezentatywnych badań empirycznych wśród młodego pokolenia, opracowania socjologicznego studium i uzupełnienia teoretycznych założeń Specjalnej Strefy Demograficznej w regionie opolskim.
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex
2014
Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.
Spectroscopy of 70Kr and isospin symmetry in the T = 1 f pg shell nuclei
2016
International audience; The recoil-β tagging technique has been used in conjunction with the 40 Ca(32 S ,2n) reaction at a beam energy of 88 MeV to identify transitions associated with the decay of the 2 + and, tentatively, 4 + states in the nucleus 70 Kr. These data are used, along with previously published data, to examine the triplet energy differences (TED) for the mass 70 isobars. The experimental TED values are compared with shell model calculations, performed with the JUN45 interaction in the fpg model space, that include a J = 0 isospin nonconserving (INC) interaction with an isotensor strength of 100 keV. The agreement is found to be very good up to spin 4 and supports the expectat…