Search results for "modeling"
showing 10 items of 4489 documents
Robust dynamical pattern formation from a multifunctional minimal genetic circuit.
2010
Abstract Background A practical problem during the analysis of natural networks is their complexity, thus the use of synthetic circuits would allow to unveil the natural mechanisms of operation. Autocatalytic gene regulatory networks play an important role in shaping the development of multicellular organisms, whereas oscillatory circuits are used to control gene expression under variable environments such as the light-dark cycle. Results We propose a new mechanism to generate developmental patterns and oscillations using a minimal number of genes. For this, we design a synthetic gene circuit with an antagonistic self-regulation to study the spatio-temporal control of protein expression. He…
Analytically solvable Hamiltonians for quantum two-level systems and their dynamics
2014
A simple systematic way of obtaining analytically solvable Hamiltonians for quantum two-level systems is presented. In this method, a time-dependent Hamiltonian and the resulting unitary evolution operator are connected through an arbitrary function of time, furnishing us with new analytically solvable cases. The method is surprisingly simple, direct, and transparent and is applicable to a wide class of two-level Hamiltonians with no involved constraint on the input function. A few examples illustrate how the method leads to simple solvable Hamiltonians and dynamics.
Variational formulations and extra boundary conditions within stress gradient elasticity theory with extensions to beam and plate models
2016
Abstract The principle of minimum total potential energy and the primary principle of virtual power for stress gradient elasticity are presented as kinematic type constructs dual of analogous static type principles from the literature (Polizzotto, 2014; Polizzotto, 2015a). The extra gradient-induced boundary conditions are formulated as “boundary congruence conditions” on the microstructure’s deformation relative to the continuum, which ultimately require that the normal derivative of the stresses must vanish at the boundary surface. Two forms of the governing PDEs for the relevant boundary-value problem are presented and their computational aspects are discussed. The Timoshenko beam and th…
Design of perfusion bioreactors and PLLA-based scaffolds for in vitro tissue engineering
2022
L'ingegneria tissutale rappresenta un nuovo approccio che integra cellule e matrici ingegnerizzate per la formazione di nuovi tessuti. In questa strategia, tre componenti essenziali costituiscono la cosiddetta triade della Tissue Engineering: segnali regolatori, cellule e scaffold tridimensionali (3D) biodegradabili e porosi. Tali elementi sono combinati per sviluppare un tessuto funzionale organizzato e 3D che simula la matrice extracellulare (ECM) del tessuto da rigenerare. Le funzioni specifiche dei tessuti nativi sono correlate agli ambienti complessi che, all'esterno del corpo, possono essere imitati usando degli strumenti chiamati bioreattori. Questi sistemi forniscono un ambiente in …
Development of helium coolant DEMO first wall model for SYCOMORE system code based on HCLL concept
2018
Abstract The conceptual design of the demonstration fusion power reactor, known as DEMO, is ongoing and several reactor configurations have to be investigated by exploring different design parameters. For these reasons, within the European framework, systems codes like SYCOMORE (SYstem COde for MOdelling tokamak REactor) have been developed. SYCOMORE includes several specific modules, one of which is aimed to define a suitable design of the helium breeding blanket. The research activity has been devoted to improve the method to define automatically the First Wall design starting from thermal-hydraulic and thermo-mechanical considerations, using analytical design formulae and, also, taking i…
Using Topic Modeling Methods for Short-Text Data: A Comparative Analysis
2020
With the growth of online social network platforms and applications, large amounts of textual user-generated content are created daily in the form of comments, reviews, and short-text messages. As a result, users often find it challenging to discover useful information or more on the topic being discussed from such content. Machine learning and natural language processing algorithms are used to analyze the massive amount of textual social media data available online, including topic modeling techniques that have gained popularity in recent years. This paper investigates the topic modeling subject and its common application areas, methods, and tools. Also, we examine and compare five frequen…
Fractional viscoelastic beam under torsion
2017
Abstract This paper introduces a study on twisted viscoelastic beams, having considered fractional calculus to capture the viscoelastic behaviour. Further another novelty of this paper is extending a recent numerical approach, labelled line elementless method (LEM), to viscoelastic beams. The latter does not require any discretization neither in the domain nor in the boundary. Some numerical applications have been reported to demonstrate the efficiency and accuracy of the method.
LEM for twisted re-entrant angle sections
2014
In this paper an innovative numerical method named as line element-less method, LEM, for finding solution of torsion problem has been extended to all shaped sections, including sections possessing re-entrant angles at their boundary. The response solution in terms of shear stress field or Prandtl function or warping function in all domain and for any kind of domain with arbitrary contour, may be performed quickly, calculating line integrals only. The method takes full advantage of the theory of analytic complex function and is robust in the sense that returns exact solution if this exists. Numerical implementation of LEM has been developed using Mathematica software without resorting to any…
Soil fungal community composition does not alter along a latitudinal gradient through the maritime and sub-Antarctic
2012
We investigated the relationships between fungal community composition, latitude and a range of physicochemical parameters in 58 soils sampled from a 2370 km latitudinal gradient between South Georgia (54 S, 38 W) in the sub-Antarctic and Mars Oasis (72 S, 68 W) on Alexander Island in the southern maritime Antarctic. Our study, which is based on approximately ten times the number of samples used in previous similar studies, indicates that latitude and its associated environmental parameters are not related to fungal community composition. Significant changes in the composition of soil fungal communities were observed in relation to gradients of the ratio of total organic carbon to nitrogen,…
Psychosocial and environmental correlates of active commuting for university students.
2009
Abstract Objective To examine psychosocial and environmental correlates of active commuting to university (ACU) and explore its association with overall physical activity among college students. Methods The sample included 518 students (mean 22.4 years; 59.7% female) from two universities in Valencia, Spain. Weekly estimations of energy expenditure from ACU and total physical activity were obtained. Socio-economic status, self-efficacy, barriers to active transport, access to car and motorbike, access to public transport, walking and cycling facilities and distance to university were assessed. Data were collected April and May of 2009, using a self-administered survey. A structural equation…