Search results for "modeling"
showing 10 items of 4489 documents
Transcriptional Regulation of Human CYP3A4 Basal Expression by CCAAT Enhancer-Binding Protein α and Hepatocyte Nuclear Factor-3γ
2003
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more than 50% of currently used therapeutic drugs, yet the mechanisms that control CYP3A4 basal expression in liver are poorly understood. Several putative binding sites for CCAAT/enhancer-binding protein (C/EBP) and hepatic nuclear factor 3 (HNF-3) were found by computer analysis in CYP3A4 promoter. The use of reporter gene assays, electrophoretic mobility shift assays, and site-directed mutagenesis revealed that one proximal and two distal C/EBP alpha binding sites are essential sites for the trans-activation of CYP3A4 promoter. No trans-activation was found in similar reporter gene experiments with a HNF-3 gamma expression vec…
A Compact SPICE Model for Organic TFTs and Applications to Logic Circuit Design
2016
This work introduces a compact DC model developed for organic thin film transistors (OTFTs) and its SPICE implementation. The model relies on a modified version of the gradual channel approximation that takes into account the contact effects, occurring at nonohmic metal/organic semiconductor junctions, modeling them as reverse biased Schottky diodes. The model also comprises channel length modulation and scalability of drain current with respect to channel length. To show the suitability of the model, we used it to design an inverter and a ring oscillator circuit. Furthermore, an experimental validation of the OTFTs has been done at the level of the single device as well as with a discrete-…
Relation entre transitivité et structure de communauté dans les réseaux complexes
2011
The relation between community structure and other topological properties in complex networks, has not been analyzed clearly. In this preliminary study, we explore experimentally the potential link between transitivity and community structure. We study the evolution of transitivity based on the quality of the community structure on artificially generated networks. Then we observe the evolution of community structure according to transitivity value. The results show a relationship between high transitivity and community structure. Additional analytical work is needed to identify the exact nature of this relationship.
Measuring job stress in transportation workers: psychometric properties, convergent validity and reliability of the ERI and JCQ among professional dr…
2021
Abstract Background The accumulated evidence has shown how professional drivers are, in psychosocial terms, among the most vulnerable workforces, and how their crashes (some of them preceded by stressful working conditions) constitute both an occupational and public health concern. However, there is a clear lack of validated tools for measuring stress and other key hazardous issues affecting transport workers, and most of the existing ones, frequently generic, do not fully consider the specific features that properly describe the work environment of professional driving. This study assessed the psychometric properties, convergent validity and consistency of two measures used for researching…
Corrigendum to “Smooth and non-smooth traveling wave solutions of some generalized Camassa–Holm equations” [19 (6) (2014) 1746–1769]
2015
Corrigendum Corrigendum to ‘‘Smooth and non-smooth traveling wave solutions of some generalized Camassa–Holm equations’’ [19 (6) (2014) 1746–1769] M. Russo , S. Roy Choudhury , T. Rehman , G. Gambino b University of Central Florida, Department of Mathematics, 4000 Central Florida Blvd., Orlando, USA University of Palermo, Department of Mathematics and Computer Science, Via Archirafi 34, 90123 Palermo, Italy
Corrigendum to “Regular and singular pulse and front solutions and possible isochronous behavior in the short-pulse equation: Phase-plane, multi-infi…
2022
Section 7 of the original paper contained several errors which are corrected here. Equations (54) and (55) are incorrect. In the following, the corrected versions of these equations are given and the subsequent results of Section 7 are also revised.
Solving a large multicontainer loading problem in the car manufacturing industry
2017
Abstract Renault, a large car manufacturer with factories all over the world, has a production system in which not every factory produces all the parts required to assemble a vehicle. Every day, large quantities of car parts are sent from one factory to another, defining very large truck/container transportation problems. The main challenge faced by the Renault logistics platforms is to load the items into trucks and containers as efficiently as possible so as to minimize the number of vehicles sent. Therefore, the problem to be solved is a multicontainer loading problem in which, besides the usual geometric constraints preventing items from overlapping and exceeding the dimensions of the c…
Bidirectional labeling for solving vehicle routing and truck driver scheduling problems
2020
Abstract This paper studies the vehicle routing and truck driver scheduling problem where routes and schedules must comply with hours of service regulations for truck drivers. It presents a backward labeling method for generating feasible schedules and shows how the labels generated with the backward method can be combined with labels generated by a forward labeling method. The bidirectional labeling is embedded into a branch-and-price-and-cut approach and evaluated for hours of service regulations in the United States and the European Union. Computational experiments show that the resulting bidirectional branch-and-price-and-cut approach is significantly faster than unidirectional counterp…
More Than Just “Stressful”? Testing the Mediating Role of Fatigue on the Relationship Between Job Stress and Occupational Crashes of Long-Haul Truck …
2021
Sergio A Useche,1,2 Francisco Alonso,1,2 Boris Cendales,3 Javier Llamazares4 1Faculty of Psychology, University of Valencia, Valencia, Spain; 2DATS (Development and Advising in Traffic Safety) Research Group, INTRAS (Research Institute on Traffic and Road Safety), University of Valencia, Valencia, Spain; 3Faculty of Economic and Administrative Sciences, El Bosque University, Bogotá, Colombia; 4Department of Technology, ESIC Business and Marketing School, Madrid, SpainCorrespondence: Sergio A UsecheDATS, Carrer del Serpis 29, 3rd Floor, Valencia, 46022, SpainTel +34 611317890Email sergio.useche@uv.esIntroduction: Recent evidence consistently highlights the adverse work environment of long-h…
The Multi-period Multi-trip Container Drayage Problem with Release and Due Dates
2021
Abstract The Container Drayage Problem (CDP) aims at routing a fleet of trucks, based at a common terminal, to serve customers while minimizing the total travel distance. Each trip starts from and ends at the terminal, and handles a subset of customers. Each customer requires either that a container is picked up or delivered. We introduce a more realistic variant, i.e., the Multi-trip Multi-period CDP with Release and Due Dates (MM-CDP-RDD), in which the planning horizon is composed of several periods (days). On each day, each truck may perform more than one trip respecting the Release and Due Dates (RDD) associated with customer services, corresponding to the first and the last day on whic…