Search results for "modelling."
showing 10 items of 1269 documents
Molecular modelling and QSAR in the discovery of HIV-1 integrase inhibitors
2007
The treatment regimens for the HIV-1 have mainly included reverse transcriptase or protease inhibitors but their long-term clinical utility is limited by severe side effects and viral drug resistance. A new attractive target for chemotherapeutic intervention can be the Integrase enzyme, that mediates the integration of HIV-1 DNA into a host chromosome, for which there is no known counterparts in the host cell. A number of derivatives have been found to inhibit IN in in vitro assays, but no successful drug based on them has emerged so far, although many compounds have been proposed. Moreover most of the inhibitors do not belong to a very precise structural class: this fact makes these compou…
QSAR Analysis of Hypoglycemic Agents Using the Topological Indices
2001
The molecular topology model and discriminant analysis have been applied to the prediction of some pharmacological properties of hypoglycemic drugs using multiple regression equations with their statistical parameters. Regression analysis showed that the molecular topology model predicts these properties. The corresponding stability (cross-validation) studies performed on the selected prediction models confirmed the goodness of the fits. The method used for hypoglycemic activity selection was a linear discriminant analysis (LDA). We make use of the pharmacological distribution diagrams (PDDs) as a visualizing technique for the identification and selection of new hypoglycemic agents, and we …
Response behaviour of reinforced concrete beams strengthened in shear with FRP
2019
In this paper an analytical model, able to predict the shear-displacement response of slender RC beams reinforced in shear with FRP, is presented. It allows to evaluate the complete strain and stress fields, for each load step, on the basis of the MCFT framework. The key role of the effective strain of FRP reinforcement at failure has been investigated. At the same time, the interaction FRP-steel stirrups has been taken into account by introducing an appropriate factor. It is able to reproduce the decrease of stirrups stress level when an external reinforcement is used. The proposed model has been validate against a database of specimens collected in literature. Results have shown the remar…
Coloring Linear Algebra
2016
[EN] We present an example of how we can introduce basic concepts on Linear Algebra in a first course of an Engineering School. We use the RGB pattern color which allows us to decompose a color into three primary colors (namely, red, green, blue). By using this model we give a natural connexion between the additivity of the color decomposition and the notions on linear algebra (as vector space, linear combination and convex linear span of vectors). To visualize these connexions we use Geogebra.
Seeking the Holy Grail: robust chronologies from archaeology and radiocarbon dating combined
2018
The strengths of formal Bayesian chronological modelling are restated, combining as it does knowledge of the archaeology with the radiocarbon dating of carefully chosen samples of known taphonomy in association with diagnostic material culture. The risks of dating bone samples are reviewed, along with a brief history of the development of approaches to the radiocarbon dating of bone. In reply to Strien (2017), selected topics concerned with the emergence and aftermath of the LBK are discussed, as well as the early Vinča, Ražište and Hinkelstein sequences. The need for rigour in an approach which combines archaeology and radiocarbon dating is underlined.
Les traces de la vitesse entre réseau et territoire : approche géohistorique de la croissance du réseau ferroviaire français
2016
The interaction between space and network are frequently questioned in the academic literature, by asking the economical and demographical impacts of a new infrastructure, often studied at the scale of a project. This work aims to investigate the components of the interaction in both large spatial and temporal scales. The hypothesis is that the temporal depth and the national scale could bring new explanations. This work is based on the collect, the exploitation and the analysis of the large spatio-temporal database FRANcE (French Railway Network). It identifies all sections of the network since the 19th century and the population census. This database also contains the traces of the speed,…
Exploring single polarization X-band weather radar potentials for local meteorological and hydrological applications
2015
Summary The aim of this study is to evaluate the potential use of a low-cost single polarization X-band weather radar, verified by a disdrometer and a dense rain gauge network, installed as a supporting tool for hydrological applications and for monitoring the urban area of Palermo (Italy). Moreover, this study focuses on studying the temporal variability of the Z–R relation for Mediterranean areas. The radar device is provided with an automatic operational ground-clutter filter developed by the producer. Attention has been paid to the development of blending procedures between radar measurements and other auxiliary instruments and to their suitability for both meteorological and hydrologic…
Influence of spatial precipitation sampling on hydrological response at catchment scale
2014
Retrieving precipitation data from raingauge network is a classical and common practice in hydrology and climatology. These data represent the key input in hydrological modeling to reproduce, for example, the characteristics of a flood phenomenon. The accuracy of the model results is strongly dependent on the consistency of the monitoring network in terms of spatial scale, i.e. network density and location of raingauges, and time resolution. In this context, several studies have been carried out to analyze how the rainfall sampling influences the estimation of total runoff volume. The aim of this paper is to use a physically based and distributed-parameter hydrologic model to investigate ho…
Précipitations et relief en Afrique orientale et australe : modélisations statistiques et géostatistiques.
2008
By considering two examples in Eastern and Southern Africa, this work has two aims: a better understanding of the influence of topography on the spatial distribution of rainfall and an optimal interpolation of station rainfall data, taking into account topography. To this end, an original methodology is developped, partly derived from previous studies focusing on extratropical regions.First, a statistical model is defined. With the help of a multi-scalar decomposition of topographical information into descriptors, a multiple linear regression is performed. This model is used to better understand the relationship between rainfall and topography. In Eastern Africa, the spatial distribution of…
Derivation of a Distributed Unit Hydrograph Integrating GIS and Remote Sensing
2007
The paper describes the results of a study based on the integration of remote sensing and geographical information system techniques to evaluate a distributed unit hydrograph model linked to an excess rainfall model for estimating the streamflow response at the outlet of a watershed. Travel time computation, based on the definition of a distributed unit hydrograph, has been performed, implementing a procedure using (1) a cell-to-cell flow path through the landscape determined from a digital elevation model (DEM); and (2) roughness parameters obtained from remote sensing data. This procedure allows the taking into account of the differences, in terms of velocity, between the hillslopes and t…