Search results for "models"

The lizard cerebral cortex as a model to study neuronal regeneration

2002

The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex…

Editorial: Unawareness of Illness in Neurological Disorders: A Focussed Neurocognitive Approach Shedding Light on Neuropsychological Deficits and Neu…

2020

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model

2020

2-Methoxyestradiol is one of the natural 17&beta

Phenomenology of non-standard neutrino interactions

2016

Today neutrino physics is in a privileged position within the fascinating field of particle physics. From the discovery of neutrino oscillations by Super-Kamiokande in 1998, the door to physics beyond the Standard Model (SM in what follows) has been opened. This fact implies that neutrinos have to be massive in opposition to the Standard Model assumption. However, this is not a surprise completely, but it was already hinted from theoretical and experimental observations in the two decades prior to the discovery of the oscillatory phenomenon, as neutrino masses included in unification models or the observed deficit of the atmospheric and solar neutrino fluxes. As a consequence of this new pa…

ENABLING LOCAL GOVERNMENTS TO DESIGN AND IMPLEMENT ANTI-CORRUPTION STRATEGIES THROUGH DYNAMIC PERFORMANCE MANAGEMENT AND GOVERNANCE. A CASE-STUDY OF …

2021

Lo scopo principale di questa ricerca è quello di inquadrare le possibili relazioni causali fra corruzione negli approvvigionamenti pubblici e performance delle amministrazioni locali. A tal fine, viene adottato un disegno di ricerca che integra dinamicamente metodi quantitativi e qualitativi in ogni fase del processo di studio. Gli approcci Dynamic Performance Management (DPM) e Governance (DPG), supportati da interviste approfondite non-strutturate, modellazioni formali e simulazioni quantitative, sono qui adottati per analizzare un caso di studio rappresentativo di un piccolo comune italiano in cui si sono verificati alcuni episodi di corruzione nelle attività di approvvigionamento nei p…

Magnetic quantum criticality in quasi-one-dimensional Heisenberg antiferromagnet Cu(C4H4N2)(NO3)2

2016

We analyze exciting recent measurements [Phys. Rev. Lett. 114 (2015) 037202] of the magnetization, differential susceptibility and specific heat on one dimensional Heisenberg antiferromagnet Cu(C4H4N2)(NO3)2 (CuPzN) subjected to strong magnetic fields. Using the mapping between magnons (bosons) in CuPzN and fermions, we demonstrate that magnetic field tunes the insulator towards quantum critical point related to so-called fermion condensation quantum phase transition (FCQPT) at which the resulting fermion effective mass diverges kinematically. We show that the FCQPT concept permits to reveal the scaling behavior of thermodynamic characteristics, describe the experimental results quantitativ…

Model społeczeństwa a założenia Specjalnej Strefy Demograficznej

2016

Założenia opolskiej Specjalnej Strefy Demograficznej odwołują się do strukturalno-systemowych teorii społeczeństwa. Stan katastrofy demograficznej wymaga, moim zdaniem, przeprowadzenia reprezentatywnych badań empirycznych wśród młodego pokolenia, opracowania socjologicznego studium i uzupełnienia teoretycznych założeń Specjalnej Strefy Demograficznej w regionie opolskim.

Spectroscopy of 70Kr and isospin symmetry in the T = 1 f pg shell nuclei

2016

International audience; The recoil-β tagging technique has been used in conjunction with the 40 Ca(32 S ,2n) reaction at a beam energy of 88 MeV to identify transitions associated with the decay of the 2 + and, tentatively, 4 + states in the nucleus 70 Kr. These data are used, along with previously published data, to examine the triplet energy differences (TED) for the mass 70 isobars. The experimental TED values are compared with shell model calculations, performed with the JUN45 interaction in the fpg model space, that include a J = 0 isospin nonconserving (INC) interaction with an isotensor strength of 100 keV. The agreement is found to be very good up to spin 4 and supports the expectat…

Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers

2020

Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003-2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnanc…

High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice

2021

In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both male and female Negr1−/− mice receiving a standard or high fat diet (HFD). We found that 6 weeks of HFD leads to higher levels of blood glucose in Negr1−/− mice. In the glucose tolerance test, HFD induced phenotype difference only in male mice