Search results for "modification"

Import and impact : characterization of parvovirus-nucleus interactions

2016

CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…

2021

Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…

Rosyjskie skrzydlate słowa w polskim dyskursie internetowym

2022

This article is devoted to the functioning of Russian winged words in the Polish Internet discourse. The analysis of the material collected from a variety of websites, blogs, comments, and demotivators showed that Russian winged words are present in the statements of Internet users. In newspaper articles and news programmes, the author or the source of the winged word appears more often, while the authors of blogs and demotivators use Russian units which have lost the link with the source and are easily modifiable. Most often, in the statements of young people there are those that do not require linguistic and cultural competences; they constitute unnamed, permanent expressions for the broa…